DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66846X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66847X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66841X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66844X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66843X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66842X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology 2007 imex curation Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Corsini L., Bonnal S., Basquin J., Hothorn M., Scheffzek K., Valcárcel J., Sattler M. DIP original experiment: DIP-66845X Nature structural & molecular biology 2007 IMEx U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. o75533-1 Splicing factor 3B subunit 1 SF3B1 SAP155 Pre-mRNA-splicing factor SF3b 155 kDa subunit Spliceosome-associated protein 155 protein protein human Homo sapiens Human MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL DIP protein O75533-1 original sequence version: 141 DIP protein O75533 original sequence version: 65 DIP protein O75533 original sequence version: 145 DIP protein O75533 original sequence version: 120 u2af2_human Splicing factor U2AF 65 kDa subunit U2AF2 U2AF65 U2 snRNP auxiliary factor large subunit U2 auxiliary factor 65 kDa subunit protein protein human Homo sapiens Human MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW DIP protein P26368 original sequence version: 86 DIP protein P26368 original sequence version: 151 DIP protein P26368-1 original sequence version: 151 DIP protein P26368 original sequence version: 124 26AD271CD8FC6211 sf01_human Splicing factor 1 Zinc finger protein 162 Transcription factor ZFM1 Zinc finger gene in MEN1 locus Mammalian branch point-binding protein SF1 ZFM1 ZNF162 protein protein human Homo sapiens Human MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN DIP protein Q15637 original sequence version: 73 DIP protein Q15637-1 original sequence version: 138 EEBC6A02B29DAE4D spf45_human Splicing factor 45 45 kDa-splicing factor RNA-binding motif protein 17 RBM17 SPF45 protein protein human Homo sapiens Human MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV DIP protein Q96I25 original sequence version: 48 DIP protein Q96I25 original sequence version: 109 99FA8C5E5E998554 sf3b1-rbm17-2 5 8 unspecified role unspecified role bait bait 330-341 binding region 330-341 binding region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST Tag GST Tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 11 unspecified role unspecified role prey prey 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q96I25:p.Asp319Lys D319K mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D K This feature has been corrected as a result of our quality control procedures. The original label was 'D319K mutation'. Wed May 02 16:20:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp319lys' Tue Jun 30 16:50:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319Lys' Q96I25:p.Glu329Gln E329Q mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain E Q This feature has been corrected as a result of our quality control procedures. The original label was 'E329Q mutation'. Wed May 02 20:02:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu329gln' Tue Jun 30 19:28:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu329Gln' Q96I25:p.Arg375Ala R375A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R375A mutation'. Wed May 02 16:03:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg375ala' Tue Jun 30 17:38:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg375Ala' Q96I25:p.Tyr376Ala Y376A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y376A mutation'. Wed May 02 18:41:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr376ala' Tue Jun 30 17:36:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr376Ala' Q96I25:p.Phe377Ala F377A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F377A mutation'. Wed May 02 17:40:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe377ala' Tue Jun 30 17:23:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe377Ala' Q96I25:p.Asp319_Asp321delinsAlaAlaAla D319A E320A D3211A mutation mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain DED AAA Fri Jul 28 10:43:17 BST 2017 This feature has been corrected as a result of our quality control procedures. The original label was 'asp_glu_asp319-321ala_ala_ala' Wed May 02 15:39:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp_glu_asp319-321ala_ala_ala' Tue Jun 30 16:17:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319_Asp321delinsAlaAlaAla' ecolx Escherichia coli direct interaction direct interaction rbm17-u2af2-1 7 9 unspecified role unspecified role neutral component neutral component 85-112 binding region 85-112 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 11 unspecified role unspecified role neutral component neutral component 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sf1-rbm17-4 6 10 unspecified role unspecified role bait bait 1-25 binding region 1-25 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain GST Tag GST Tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 11 unspecified role unspecified role prey prey 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q96I25:p.Arg375Asp R375D mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R D This feature has been corrected as a result of our quality control procedures. The original label was 'R375D mutation'. Wed May 02 16:11:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg375asp' Tue Jun 30 16:25:25 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg375Asp' Q96I25:p.Asp319Lys D319K mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D K This feature has been corrected as a result of our quality control procedures. The original label was 'D319K mutation'. Wed May 02 16:33:44 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp319lys' Tue Jun 30 17:27:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319Lys' Q96I25:p.Asp319Ala D319A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D319A mutation'. Wed May 02 19:45:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp319ala' Tue Jun 30 16:05:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319Ala' Q96I25:p.Arg375Ala R375A mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R375A mutation'. Wed May 02 16:37:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg375ala' Tue Jun 30 17:40:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg375Ala' Q96I25:p.Tyr376Ala Y376A mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y376A mutation'. Wed May 02 16:26:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr376ala' Tue Jun 30 16:57:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr376Ala' Q96I25:p.Phe377Ala F377A mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F377A mutation'. Wed May 02 15:49:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe377ala' Tue Jun 30 15:44:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe377Ala' Q96I25:p.Phe377Tyr F377Y mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F Y This feature has been corrected as a result of our quality control procedures. The original label was 'F377Y mutation'. Wed May 02 17:56:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe377tyr' Tue Jun 30 16:55:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe377Tyr' ecolx Escherichia coli direct interaction direct interaction u2af2-rbm17-1 3 9 unspecified role unspecified role bait bait 85-112 binding region 85-112 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain GST Tag GST Tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 11 unspecified role unspecified role prey prey 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q96I25:p.Arg375Asp R375D mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R D This feature has been corrected as a result of our quality control procedures. The original label was 'R375D mutation'. Wed May 02 17:27:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg375asp' Tue Jun 30 17:54:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg375Asp' Q96I25:p.Asp319Lys D319K mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D K This feature has been corrected as a result of our quality control procedures. The original label was 'D319K mutation'. Wed May 02 18:42:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp319lys' Tue Jun 30 18:02:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319Lys' Q96I25:p.Glu329Gln E329Q mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain E Q This feature has been corrected as a result of our quality control procedures. The original label was 'E329Q mutation'. Wed May 02 18:59:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu329gln' Tue Jun 30 15:43:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu329Gln' Q96I25:p.Arg375Ala R375A mutation mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R375A mutation'. Wed May 02 16:48:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg375ala' Tue Jun 30 19:37:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg375Ala' Q96I25:p.Phe377Ala F377A mutation mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F377A mutation'. Wed May 02 18:16:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe377ala' Tue Jun 30 20:16:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe377Ala' Q96I25:p.Asp319_Asp321delinsAlaAlaAla D319A E320A D3211A mutation mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain DED AAA Fri Jul 28 10:53:23 BST 2017 This feature has been corrected as a result of our quality control procedures. The original label was 'asp_glu_asp319-321ala_ala_ala' Wed May 02 18:03:06 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp_glu_asp319-321ala_ala_ala' Tue Jun 30 18:16:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319_Asp321delinsAlaAlaAla' ecolx Escherichia coli direct interaction direct interaction rbm17-sf1-3 1 10 unspecified role unspecified role neutral component neutral component 1-25 binding region 1-25 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 11 unspecified role unspecified role neutral component neutral component 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rbm17-sf3b1-1 2 8 unspecified role unspecified role neutral component neutral component 317-357 binding region 317-357 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 11 unspecified role unspecified role neutral component neutral component 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction rbm17-sf3b1-2 4 8 unspecified role unspecified role neutral component neutral component 333-342 binding region 333-342 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 11 unspecified role unspecified role neutral component neutral component 301-401 binding region 301-401 binding region sufficient to bind sufficient binding region sufficient to bind predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction