DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Wang D., Hu J., Bobulescu IA., Quill TA., McLeroy P., Moe OW., Garbers DL. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang D., Hu J., Bobulescu IA., Quill TA., McLeroy P., Moe OW., Garbers DL. DIP original experiment: DIP-261553X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Wang D., Hu J., Bobulescu IA., Quill TA., McLeroy P., Moe OW., Garbers DL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang D., Hu J., Bobulescu IA., Quill TA., McLeroy P., Moe OW., Garbers DL. DIP original experiment: DIP-261552X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). sl9c1_mouse Sodium/hydrogen exchanger 10 Slc9c1 Gm610 Slc9a10 Na(+)/H(+) exchanger 10 Solute carrier family 10 member 10 Solute carrier family 9 member C1 Sperm-specific Na(+)/H(+) exchanger protein protein mouse Mus musculus Mouse MEMEEISENLTASHSIKLTNMWLELLKSVFLSTPQDLPEIILILSLICTVGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQIYADAIQWMDPDIFFGIFTPVIIFNVAFDMDIYMLQKLFWQILVITIPGFLINYTLILWYLQSVNKLSLKTVPWLLFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVLSLVIYSGVVHIRFKSKSVNHTLAHKVMSTAWSYIVESFITGIVFTKVIQLWMATIFGDDVNHITLIFSVLYLIFYVCELVGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLIPAHTYLHISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEMKGTPNINMALLLAYSDISLGSERERSQILFHGVSVCVITLIVNRFILPMAVTKLGLRDVTSTKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDNAIILQNPYAMNQEEITEHQKVKCPDCNKEIDETLNIEAMELTNRRLLSAQIASYQRQYRNEVLSQSAVQVLVGAAGSFGEKKGEYMSPENIKNFSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHACHRIVFTNEFEYTGYLVVLMSTYPMIICWISRLKDIYDNEIKCANYYFLAFYILEALLKVAAMRKEFFSHTWLLFELGITLVGVLDIILIETDSISYNFDLTETVVFMNVIRLLRILRILKLVTPKLLQIIDKRMSQQISFRYSILKGYVQGEMDVLNIIDQIASSKQTKQILLKRVMRNMEHAMKELGYLEYDHPEIAVTMKTKEEINVMLNMAREIVKAFRSKGIIHKVEGTEINKLIMAKKIQVLDLQSVIQPFNVEEAPCNIPWLSEDPEAITFIQEKAKVVTFDCGNNIFEEGDEPEGIYVIISGMVKLKRSKPHLEMERVSAESEIKIHPLPHTEYLLSGEIIGELNCLTKERMQYSATCKTVVETYFIPISHLYEGFEKRCPNMKHKMWQKIGLAITAQKIREHLSFEDWNYKLQLKLCNAFIRDIPKSMKTDIYDETVTHVVLIHGSAEDCQLRKIYKAPFLIPVTCHQIQGMEDFTKVMIIQTSIAVRKFRWNVRKYIPPRRISMKPDSERESFETLDETSEEDNGKKENQENEELIEENINI DIP protein Q6UJY2 original sequence version: 82 adcya_mouse Adenylate cyclase type 10 Adcy10 Sac Sacy Germ cell soluble adenylyl cyclase Testicular soluble adenylyl cyclase protein protein mouse Mus musculus Mouse MSARRQELQDRAIVKIAAHLPDLIVYGDFSPERPSVKCFDGVLMFVDISGFTAMTEKFSTAMYMDRGAEQLVEILNYYISAIVEKVLIFGGDILKFAGDALLALWKVERKQLKNIITVVIKCSLEIHGLFEAKEAEEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFTKCMGFMDYYPSGDHKNFLRLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVNLMFKEQDKVEVIGSAIQAACVHITSVLKVFRGQINKVFMFDKGCSFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVHKIRTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARMMMYYPGIVSCDSVTYDGSNLPAYFFKELPKKVMKGVADPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRVREIDYFMSTMKDFLMTNCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILMANVLGLDTCKHYKERQTNLQNRVKTLLDEKFHCLLNDIFHVQFPVSREMSRMSKIRKQKQLEALFMKILAQTVREERIIFIIDEAQFVDGTSWAFIEKLIRSMPIFIVMSLAPFSEVPCAAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIPRELDSYLVEGSCGIPYYCEELLKNLDHHRVLLFQQAETEQKTNVTWNNMFKHSVRPTDDMQLFTSISEGQKEVCYLVSGVRLNNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKALATLVESNVFNCFRSSKDLQLALKQNVPTFEVHYRSLALKLKEGLTYGEEEELREMEGEVVECRILRFCRPIMQKTAYELWLKDQKKVLHLKCARFLEESAHRCNHCRNVDFIPYHHFIVDIRLNTLDMDTVKRMVTSQGFKIDEEEAIFSKSELPRKYKFPENLSITEIREKILHFFDNVILKMKSSPNDIIPLESCQCKELLQIVILPLAQHFVALEENNKALYYFLELASAYLILGDNYNAYMYLGEGERLLKSLTNEDSWSQTFEYATFYSLKAEVCFNMGQMVLAKKMLRKALKLLNRMFPCNLLTLTFQMHVEKNRLSHFMNQHTQEGSVPGKKLAQLYLQASCFSLLWRIYSLNFFFHYKYYGHLAAMMEMNTSLETQNDFQIIKAYLDFSLYHHLAGYQGVWFKYEILVMEQLLNLPLKGEAIEIMAYTADTLGHIKFLMGHLDLAIELGSRAHRMWSLLRNPNKYQMVLCRLSKPLFLKSRYKHLVQVLGWLWDLSVTEEDIFSKAFFYFVCLDIMLYSGFIYRTFEECLEFIHHNEDNRILKFQSGLLLGLYSCIAVWYARLQEWDNFNKFSDRAKHLVTRRTPTVLYYEGISRYMEGQVLHLQKQIEEQAENAQDSGVEILKALETLVAQNTTGPVFYPRLYHLMAYVCILMGDGHSCDFFLNTALELSETHGNLLEKCWLSMSKEWWYSASELTGDQWLQTVLSLPSWDKIVSGKGGQRKRSWSWFCPPNFSMVSWSQPQCA DIP protein Q8C0T9 original sequence version: 97 adcy10-slc9c1-1 2 3 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 891-1121 Region 891-1121 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 4 unspecified role unspecified role bait bait Region 1-469 Region 1-469 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association slc9c1-adcy10-1 1 4 unspecified role unspecified role prey prey mouse Mus musculus Mouse 3 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association