DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 imex curation Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. DIP original experiment: DIP-253303X Nature 2007 IMEx Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 imex curation Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. DIP original experiment: DIP-253307X Nature 2007 IMEx Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 imex curation Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. DIP original experiment: DIP-253304X Nature 2007 IMEx Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 imex curation Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. DIP original experiment: DIP-253306X Nature 2007 IMEx Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 imex curation Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. DIP original experiment: DIP-253302X Nature 2007 IMEx Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007 imex curation Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang J., Scully K., Zhu X., Cai L., Zhang J., Prefontaine GG., Krones A., Ohgi KA., Zhu P., Garcia-Bassets I., Liu F., Taylor H., Lozach J., Jayes FL., Korach KS., Glass CK., Fu XD., Rosenfeld MG. DIP original experiment: DIP-253305X Nature 2007 IMEx Opposing LSD1 complexes function in developmental gene activation and repression programmes. kdm1a_mouse Lysine-specific histone demethylase 1A Kdm1a Kiaa0601 Lsd1 Flavin-containing amine oxidase domain-containing protein 2 BRAF35-HDAC complex protein BHC110 Aof2 protein protein mouse Mus musculus Mouse MLSGKKAAAAAAAAAAAAAAGTEAGSGAAGGAENGSEVAAPPAGLTGPTDMATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM DIP protein Q6ZQ88 original sequence version: 98 DIP protein Q6ZQ88 original sequence version: 82 DIP protein Q6ZQ88 original sequence version: 125 DIP protein Q6ZQ88 original sequence version: 86 DIP protein Q6ZQ88 original sequence version: 65 43CD401FA0452B2F pit1_mouse Pituitary-specific positive transcription factor 1 Pou1f1 Pit-1 Pit1 Growth hormone factor 1 protein protein mouse Mus musculus Mouse MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDPAASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISVAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR DIP protein Q00286 original sequence version: 128 lcor_mouse Ligand-dependent corepressor Lcor Kiaa1795 Mlr2 Mblk1-related protein 2 protein protein mouse Mus musculus Mouse MQRMIQQFAAEYTSKTSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCASSTSLSHSPGCSSTQGNGRPGRPSQYRPDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSLQISEELLSRNQLSTAASLGPSGLQNHGQHLILSREASWAKPHYEFSLSRMKFRGNGALSNISDLPFLAENSAFPKMAHQTKQDGKRDMSHSSPVDLKIPQVRGMDLSWESRTGDQYSYSSLVMGSQTESALSKKLRAILPKQNRKSMLDAGPDSWGSDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKERLGTLKNPPKKKMKLMRSEGPDVSVKIELDPQGEAAQSANESKTE DIP protein Q6ZPI3 original sequence version: 63 rcor1_mouse REST corepressor 1 Rcor1 D12Wsu95e Kiaa0071 Protein CoREST protein protein mouse Mus musculus Mouse MPAMVEKGPEVSGKRRGRNTAASAASAAASAASAAASAAASAGTASASAAAAASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEETNGSNPVDIEIDPNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSIKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKDETNGPANQKPVKSPESSIKIPEEEDEAASVLDVRYASAS DIP protein Q8CFE3 original sequence version: 97 DIP protein Q8CFE3 original sequence version: 86 DIP protein Q8CFE3 original sequence version: 68 7FA2AEA127EA297A zeb1_mouse Zinc finger E-box-binding homeobox 1 Zeb1 Tcf8 Zfhx1a Zfx1a Zfx1ha Transcription factor 8 Zinc finger homeobox protein 1a Delta EF1 protein protein mouse Mus musculus Mouse MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEEESITDAADCEGGMPDDELPADQTVLPGGSDRGGGAKNCWQDNVKDNECDSDAENEQNHDPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASSHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLMPVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSSGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLETNQASLASKEQEAVSASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKEIPAPTNSCKSEKLPEDLTVKSETDKSFEGARDDSTCLLCEDCPGDLNALPELKHYDPECPAQPPPPAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPSTEELSKIADSVNLPLDGVKKWFEKMQAGQIPGQSPDPPSPGTGSVNIPTKTDEQPQPADGNEPQEDSTRGQSPVKIRSSPVLPVGSAMNGSRSCTSSPSPLNLCSARNPQGYSCVAEGAQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSATVSPAVQEPPVKVIQPNGNQDERQDTSSEGVSTVEDQNDSDSTPPKKKTRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDAMEQEDAGPEVLPEVLATEHVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEELQEGKECENPQGEEEEEEEEEEEEEEEEEEEVEADEAEHEAAAKTDGTVEVGAAQQAGSLEQKASESEMESESESEQLSEEKTNEA DIP protein Q64318 original sequence version: 120 mint Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes D1FAC2D048D34237 rbpjl_human Recombining binding protein suppressor of hairless-like protein RBPJL RBPL RBPSUHL Transcription factor RBP-L protein protein human Homo sapiens Human MDPAGAADPSVPPNPLTHLSLQDRSEMQLQSEADRRSLPGTWTRSSPEHTTILRGGVRRCLQQQCEQTVRILHAKVAQKSYGNEKRFFCPPPCVYLSGPGWRVKPGQDQAHQAGETGPTVCGYMGLDSASGSATETQKLNFEQQPDSREFGCAKTLYISDADKRKHFRLVLRLVLRGGRELGTFHSRLIKVISKPSQKKQSLKNTDLCISSGSKVSLFNRLRSQTVSTRYLSVEDGAFVASARQWAAFTLHLADGHSAQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDVDEPISQLHKCAFQFPGSPPGGGGTYLCLATEKVVQFQASPCPKEANRALLNDSSCWTIIGTESVEFSFSTSLACTLEPVTPVPLISTLELSGGGDVATLELHGENFHAGLKVWFGDVEAETMYRSPRSLVCVVPDVAAFCSDWRWLRAPITIPMSLVRADGLFYPSAFSFTYTPEYSVRPGHPGVPEPATDADALLESIHQEFTRTNFHLFIQT DIP protein Q9UBG7 original sequence version: 105 1DB1505A800F7788 ctbp1_mouse C-terminal-binding protein 1 Ctbp1 protein protein mouse Mus musculus Mouse MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYSRYPPGVVSVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHTSDQL DIP protein O88712 original sequence version: 122 DIP protein O88712 original sequence version: 125 2105CC8D69D915F4 kdm1a-rbpjl-1 5 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 12 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association kdm1a-rcor1-4 2 10 unspecified role unspecified role prey prey mouse Mus musculus Mouse 7 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association kdm1a-lcor-1 6 9 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association kdm1a-pou1f1-1 1 7 unspecified role unspecified role bait bait mouse Mus musculus Mouse 8 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association kdm1a-zeb1-1 3 11 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association ctbp1-kdm1a-1 4 11 unspecified role unspecified role prey prey mouse Mus musculus Mouse 13 unspecified role unspecified role bait bait mouse Mus musculus Mouse 7 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association