DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structure (London, England : 1993) 2007 imex curation Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. DIP original experiment: DIP-66626X Structure (London, England : 1993) 2007 IMEx Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structure (London, England : 1993) 2007 imex curation Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. DIP original experiment: DIP-66627X Structure (London, England : 1993) 2007 IMEx Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structure (London, England : 1993) 2007 imex curation Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. DIP original experiment: DIP-66625X Structure (London, England : 1993) 2007 IMEx Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structure (London, England : 1993) 2007 imex curation Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. Only protein-protein interactions ecolx Escherichia coli light scattering light scattering predetermined predetermined participant predetermined Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. DIP original experiment: DIP-66624X Structure (London, England : 1993) 2007 IMEx Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structural basis for the actin-binding function of missing-in-metastasis. Structure (London, England : 1993) 2007 imex curation Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lee SH., Kerff F., Chereau D., Ferron F., Klug A., Dominguez R. DIP original experiment: DIP-66623X Structure (London, England : 1993) 2007 IMEx Structural basis for the actin-binding function of missing-in-metastasis. mtss1_human Protein MTSS 1 Missing in metastasis protein Metastasis suppressor YGL-1 MTSS1 KIAA0429 MIM Metastasis suppressor protein 1 protein protein human Homo sapiens Human MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS DIP protein O43312 original sequence version: 54 76FEE3224CBA9287 acts_rabit Actin, alpha skeletal muscle ACTA1 ACTA Alpha-actin-1 protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF DIP protein P68135 original sequence version: 41 DIP protein P68135 original sequence version: 27 DIP protein P68135 original sequence version: 28 DIP protein P68135 original sequence version: 96 DIP protein P68135 original sequence version: 29 DIP protein P68135 original sequence version: 89 DIP protein P68135 original sequence version: 39 DIP protein P68135 original sequence version: 42 DIP protein P68135 original sequence version: 59 DIP protein P68135 original sequence version: 55 DIP protein P68135 original sequence version: 60 DIP protein P68135 original sequence version: 65 DIP protein P68135 original sequence version: 67 DIP protein P68135 original sequence version: 63 DIP protein P68135 original sequence version: 68 DIP protein P68135 original sequence version: 79 DIP protein P68135 original sequence version: 88 DIP protein P68135 original sequence version: 84 DIP protein P68135 original sequence version: 101 DIP protein P68135 original sequence version: 94 DIP protein P68135 original sequence version: 95 DIP protein P68135 original sequence version: 97 DIP protein P68135 original sequence version: 100 DIP protein P68135 original sequence version: 102 DIP protein P68135 original sequence version: 83 DF2A3A046346A179 dnas1_bovin Deoxyribonuclease-1 DNASE1 DNL1 Deoxyribonuclease I protein protein bovin Bos taurus (Bovine) Bovine MRGTRLMGLLLALAGLLQLGLSLKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEVRDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYDDGCESCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKWHLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADTTATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYGLSNEMALAISDHYPVEVTLT DIP protein P00639 original sequence version: 78 DIP protein P00639 original sequence version: 132 DIP protein P00639 original sequence version: 109 mint Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization 43904EF0D5F2E0E2 mtss1_mouse Protein MTSS 1 Mtss1 Mim Missing in metastasis protein Metastasis suppressor protein 1 protein protein mouse Mus musculus Mouse MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKNKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAANQLSNGFSHCSLSSESHAGPVGAGPFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDSNGGGPTTTGGPPAGAEEAQRPRSMTVSAATRPGEEMAACEELTLALSRGLQLDVQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEAEQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPSPPDGPEERGEHSPESPSAGEGPQGVSNIPSSLWSGQAPVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATVSPGPIPESDPADLSPRESPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS DIP protein Q8R1S4 original sequence version: 36 DIP protein Q8R1S4 original sequence version: 85 q9uqb8-2 Brain-specific angiogenesis inhibitor 1-associated protein 2 BAIAP2 Fas ligand-associated factor 3 Insulin receptor substrate p53/p58 Insulin receptor substrate protein of 53 kDa protein protein human Homo sapiens Human MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRSAPLLS DIP protein Q9UQB8-2 original sequence version: 47 E63C4C08C48964B7 mtss1-1 5 9 unspecified role unspecified role unspecified role unspecified role Region 1-250 Region 1-250 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mtss1-2 4 9 unspecified role unspecified role unspecified role unspecified role Region 1-250 Region 1-250 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction acta1-mtss1-1 3 7 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit 9 unspecified role unspecified role unspecified role unspecified role Region 1-250 Region 1-250 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction acta1-dnase1-1 1 8 unspecified role unspecified role unspecified role unspecified role bovin Bos taurus (Bovine) Bovine 6 unspecified role unspecified role unspecified role unspecified role Region 724-755 Region 724-755 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction acta1-baiap2-1 2 10 unspecified role unspecified role unspecified role unspecified role Region 506-534 Region 506-534 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction