<?xml version='1.0' encoding='UTF-8'?>
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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Substrate interactions with human ferrochelatase.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="17261801" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0606144104" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15620291" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-22719" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Substrate interactions with human ferrochelatase.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2007</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Medlock A.,  Swartz L.,  Dailey TA.,  Dailey HA.,  Lanzilotta WN.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-22719" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="2HRC" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-260995X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="2HRE" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="17261801" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0606144104" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="562">
            <names>
              <shortLabel>ecolx</shortLabel>
              <fullName>Escherichia coli</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Medlock A., Swartz L., Dailey TA., Dailey HA., Lanzilotta WN.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-260995X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2007</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Substrate interactions with human ferrochelatase.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>hemh_human</shortLabel>
          <fullName>Ferrochelatase, mitochondrial</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Protoheme ferro-lyase</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Heme synthase</alias>
          <alias type="gene name" typeAc="MI:0301">FECH</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P22830" version="SP_91" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8IXN1" version="SP_91" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8NAN0" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8KA72" version="SP_111" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000262093" version="SP_218" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1390356" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000131.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001012533.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-39632N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000066926" version="SP_218" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000262093" version="SP_218" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004325" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005743" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005759" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006091" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006783" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008198" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009416" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010288" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0017085" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045471" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046501" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046685" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051537" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051597" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070541" version="SP_218"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071549" version="SP_218"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001015" version="SP_218"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019772" version="SP_218"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033644" version="SP_218"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033659" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HRK" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2HRC" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2HRE" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2PNJ" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2PO5" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2PO7" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD1" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD2" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD3" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD4" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD5" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3AQI" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HCN" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HCO" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HCP" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HCR" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3W1W" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4F4D" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KLA" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KLC" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KLR" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KMM" version="SP_218"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4MK4" version="SP_218"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-189451" version="SP_218"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P22830 original sequence version: 155</attribute>
          <attribute name="crc64">3FD50965E8DEABCE</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-22719-1">
        <names>
          <shortLabel>fech-5</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-196615E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15620312" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22719-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>