DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260590X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260593X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260589X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260592X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260591X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. ctsr3_mouse Cation channel sperm-associated protein 3 Catsper3 protein protein mouse Mus musculus Mouse MSQHFHHNPVRVKSGSLFATASEALQARLSKIKRKDKECQAYFRKVIKSTFFQIVMITTVTTNSFLLVLGTNYDIQFEFFRTFEVSELFFVSVYVCEFLMKVYVDPITYWKDGYNILDVIILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFGVTDRGDLENWGNLASAFFTLFSLATVDGWTDLQEELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSMKKFERDLTLERNLAIMEEKQIILKRQQEEVNRLMNTQKSGSMNFIDMVEGFKKTLRHTDPMVLDDFSTSLSFIDIYLVTLDNQDVIVSKLQELYCEIVNVLSLMLEDMPKESSSSLSGLS DIP protein Q80W99 original sequence version: 78 ctsr4_mouse Cation channel sperm-associated protein 4 Catsper4 protein protein mouse Mus musculus Mouse MSEKHKWWQQVENIDITHLGPKRKAYELLGRHEEQVLINRRDVMEKKDAWDVQEFITQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFSTIDDIVLTILICEVLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEARKDTSTVPKEPLVGGPLSNLTEKTCDNFCLVLEAIQENLMEYKEIREELNMIVEEVSSIRFNQEQQNVILHKYTSKSATFLSEPPEGANKQDLITALVSREKVSDSNINMVNKHKFSH DIP protein Q8BVN3 original sequence version: 94 ctsr1_mouse Cation channel sperm-associated protein 1 Catsper1 protein protein mouse Mus musculus Mouse MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK DIP protein Q91ZR5 original sequence version: 86 ctsr2_mouse Cation channel sperm-associated protein 2 Catsper2 protein protein mouse Mus musculus Mouse MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK DIP protein A2ARP9 original sequence version: 51 Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization mint 93396326105828DA catsper2-catsper1-1 3 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association catsper1-catsper3-1 4 6 unspecified role unspecified role prey prey mouse Mus musculus Mouse 8 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association catsper3-catsper1-1 1 6 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association catsper1-catsper4-1 2 7 unspecified role unspecified role prey prey mouse Mus musculus Mouse 8 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association catsper4-catsper1-1 5 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association