DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The dimerization of an alpha/beta-knotted protein is essential for structure and function. The dimerization of an alpha/beta-knotted protein is essential for structure and function. Structure (London, England : 1993) 2007 imex curation Mallam AL., Jackson SE. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Mallam AL., Jackson SE. DIP original experiment: DIP-66407X Structure (London, England : 1993) 2007 IMEx The dimerization of an alpha/beta-knotted protein is essential for structure and function. The dimerization of an alpha/beta-knotted protein is essential for structure and function. The dimerization of an alpha/beta-knotted protein is essential for structure and function. Structure (London, England : 1993) 2007 imex curation Mallam AL., Jackson SE. Only protein-protein interactions ecolx Escherichia coli cd circular dichroism CD CD cd predetermined predetermined participant predetermined Mallam AL., Jackson SE. DIP original experiment: DIP-66408X Structure (London, England : 1993) 2007 IMEx The dimerization of an alpha/beta-knotted protein is essential for structure and function. trml_haein tRNA (cytidine(34)-2'-O)-methyltransferase trmL tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL HI_0766 protein protein haein Haemophilus influenzae MLDIVLYEPEIPQNTGNIIRLCANTGFRLHLIEPLGFTWDDKRLRRSGLDYHEFAEIKRHKTFEAFLESEKPKRLFALTTKGCPAHSQVKFKLGDYLMFGPETRGIPMSILNEMPMEQKIRIPMTANSRSMNLSNSVAVTVYEAWRQLGYKGAVNLPEVK 0E09ADB31E575026 yibk-1 1 3 unspecified role unspecified role unspecified role unspecified role P44868:p.Glu143Lys E143K mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E K This feature has been corrected as a result of our quality control procedures. The original label was 'E143K'. Wed May 02 18:10:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu143lys' Tue Jun 30 19:25:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu143Lys' P44868:p.Val139Arg V139R mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V R This feature has been corrected as a result of our quality control procedures. The original label was 'V139R'. Wed May 02 17:37:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val139arg' Tue Jun 30 16:48:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val139Arg' P44868:p.[Arg20Asp;Asn24Ala;Ser87Ala;Val139Arg;Tyr142Phe;Glu143Lys] R20D, N24A, S87A, V139R, Y142F, and E143K mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain R D certain certain sequence position certain certain certain sequence position certain E K certain certain sequence position certain certain certain sequence position certain Y F certain certain sequence position certain certain certain sequence position certain V R This feature has been corrected as a result of our quality control procedures. The original label was 'R20D, N24A, S87A, V139R, Y142F, and E143K'. Wed May 02 15:39:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg20asp,asn24ala,ser87ala,val139arg,tyr142phe,glu143lys' Tue Jun 30 16:27:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg20Asp;Asn24Ala;Ser87Ala;Val139Arg;Tyr142Phe;Glu143Lys]' ecolx Escherichia coli direct interaction direct interaction yibk-2 2 3 unspecified role unspecified role unspecified role unspecified role P44868:p.Val139Arg V139R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain V R This feature has been corrected as a result of our quality control procedures. The original label was 'V139R'. Wed May 02 20:18:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val139arg' Tue Jun 30 17:37:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val139Arg' P44868:p.[Arg20Asp;Asn24Ala;Ser87Ala;Val139Arg;Tyr142Phe;Glu143Lys] R20D, N24A, S87A, V139R, Y142F, and E143K mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain R D certain certain sequence position certain certain certain sequence position certain E K certain certain sequence position certain certain certain sequence position certain Y F certain certain sequence position certain certain certain sequence position certain V R This feature has been corrected as a result of our quality control procedures. The original label was 'R20D, N24A, S87A, V139R, Y142F, and E143K'. Wed May 02 16:52:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg20asp,asn24ala,ser87ala,val139arg,tyr142phe,glu143lys' Tue Jun 30 18:13:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg20Asp;Asn24Ala;Ser87Ala;Val139Arg;Tyr142Phe;Glu143Lys]' P44868:p.[Arg20Asp;Asn24Ala;Ser87Ala;Tyr142Phe;Glu143Lys] R20D, N24A, S87A, Y142F, and E143K mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain R D certain certain sequence position certain certain certain sequence position certain E K certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'R20D, N24A, S87A, Y142F, and E143K'. Wed May 02 19:07:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg20asp,asn24ala,ser87ala,tyr142phe,glu143lys' Tue Jun 30 17:11:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg20Asp;Asn24Ala;Ser87Ala;Tyr142Phe;Glu143Lys]' ecolx Escherichia coli direct interaction direct interaction