DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. Nature 2007 imex curation Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. DIP original experiment: DIP-253220X Nature 2007 IMEx A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. Nature 2007 imex curation Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. DIP original experiment: DIP-253222X Nature 2007 IMEx A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. Nature 2007 imex curation Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. DIP original experiment: DIP-253221X Nature 2007 IMEx A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. Nature 2007 imex curation Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. DIP original experiment: DIP-253219X Nature 2007 IMEx A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. Nature 2007 imex curation Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. DIP original experiment: DIP-253223X Nature 2007 IMEx A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. A stomatin-domain protein essential for touch sensation in the mouse. Nature 2007 imex curation Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Wetzel C., Hu J., Riethmacher D., Benckendorff A., Harder L., Eilers A., Moshourab R., Kozlenkov A., Labuz D., Caspani O., Erdmann B., Machelska H., Heppenstall PA., Lewin GR. DIP original experiment: DIP-253224X Nature 2007 IMEx A stomatin-domain protein essential for touch sensation in the mouse. asic3_rat Acid-sensing ion channel 3 Asic3 Accn3 Amiloride-sensitive cation channel 3 Dorsal root ASIC Drasic protein protein rat Rattus norvegicus (Rat) Rat MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTTPCAVTKTLSASHRTCYLVTRL DIP protein O35240 original sequence version: 94 294B57322C74B3DC q62962-1 Acid-sensing ion channel 2 Asic2 Accn1 Bnac1 Mdeg Mdeg1 Asic2a Amiloride-sensitive brain sodium channel Amiloride-sensitive brain sodium channel 2 Amiloride-sensitive cation channel 1, neuronal Amiloride-sensitive cation channel neuronal 1 Brain sodium channel 1 Mammalian degenerin homolog protein protein rat Rattus norvegicus (Rat) Rat MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC DIP protein Q62962-1 original sequence version: 102 q62962-2 Acid-sensing ion channel 2 Asic2 Accn1 Amiloride-sensitive brain sodium channel Amiloride-sensitive brain sodium channel 2 Amiloride-sensitive cation channel 1, neuronal Amiloride-sensitive cation channel neuronal 1 Bnac1 Brain sodium channel 1 Mammalian degenerin homolog Mdeg Asic2b Mdeg2 protein protein rat Rattus norvegicus (Rat) Rat MSRSGGARLPATALSGPGRFRMAREQPAPVAVAAARQPGGDRSGDPALQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC Seems to be inactive as monomer or in a monomeric assembly and is not activated by mutagenesis of Gly-430. Mutagenesis of Ser-60 into Gly reduces activation by PKC through PRKCABP/PICK-1 of a ASIC3/ACCN3-ASIC2/ASIC2b channel. d4a100_rat Stoml3 Stoml3_predicted rCG_49955 protein protein rat Rattus norvegicus (Rat) Rat MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLITFPVSIWMCLKIIKEYERAVVFRLGRIQADKAKGPGTAETMGTTTTTTTTTTTTTTTTTISTTTTTRGIY DIP protein D4A100 original sequence version: 23 stoml3-asic2-1 3 9 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 10 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association stoml3-asic2-2 4 8 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 10 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association stoml3-asic3-1 5 7 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 10 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association asic2-stoml3-1 2 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 10 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association asic2-stoml3-2 1 8 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 10 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association asic3-stoml3-1 6 10 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association