DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nature structural & molecular biology 2006 imex curation Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66518X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nature structural & molecular biology 2006 imex curation Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66516X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nature structural & molecular biology 2006 imex curation Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66517X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nature structural & molecular biology 2006 imex curation Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66519X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. gbg1_bovin Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Transducin gamma chain protein protein bovin Bos taurus (Bovine) Bovine MPVINIEDLTEKDKLKMEVDQLKKEVTLERMLVSKCCEEFRDYVEERSGEDPLVKGIPEDKNPFKELKGGCVIS DIP protein P02698 original sequence version: 68 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction mint B12B580FABDB1C05 gbb1_bovin Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Transducin beta chain 1 protein protein bovin Bos taurus (Bovine) Bovine MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN DIP protein P62871 original sequence version: 29 DIP protein P62871 original sequence version: 61 DIP protein P62871 original sequence version: 64 896CBD32D2686598 opsd_bovin Rhodopsin RHO protein protein bovin Bos taurus (Bovine) Bovine MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA DIP protein P02699 original sequence version: 157 DIP protein P02699 original sequence version: 158 DIP protein P02699 original sequence version: 88 DIP protein P02699 original sequence version: 160 DIP protein P02699 original sequence version: 152 DIP protein P02699 original sequence version: 136 DIP protein P02699 original sequence version: 135 DIP protein P02699 original sequence version: 141 mint Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal 33FDA196803E81F3 gnat1_bovin Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 Transducin alpha-1 chain protein protein bovin Bos taurus (Bovine) Bovine MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF DIP protein P04695 original sequence version: 74 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase mint 36F0B4630EFBD7DF gnat1-gnb1-3 2 7 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine 5 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine 8 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli 6 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine physical association physical association gnat1-gnb1-4 3 7 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine 5 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine 8 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli 6 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine physical association physical association gnat1-rho-1 1 7 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine 8 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli physical association physical association gnat1-rho-2 4 7 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine 8 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli physical association physical association