DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis for transcription inhibition by tagetitoxin. Structural basis for transcription inhibition by tagetitoxin. Nature structural & molecular biology 2005 imex curation Vassylyev DG., Svetlov V., Vassylyeva MN., Perederina A., Igarashi N., Matsugaki N., Wakatsuki S., Artsimovitch I. Only protein-protein interactions thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Vassylyev DG., Svetlov V., Vassylyeva MN., Perederina A., Igarashi N., Matsugaki N., Wakatsuki S., Artsimovitch I. DIP original experiment: DIP-254811X Nature structural & molecular biology 2005 IMEx Structural basis for transcription inhibition by tagetitoxin. rpob_thet8 DNA-directed RNA polymerase subunit beta Transcriptase subunit beta RNA polymerase subunit beta TTHA1813 rpoB protein protein thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRENVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQDECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPLMTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERMLMGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVTDEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGEPVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALMGSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPERITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSFKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQAFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPEEQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPSVPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR DIP protein Q8RQE9 original sequence version: 83 DIP protein Q8RQE9 original sequence version: 63 DIP protein Q8RQE9 original sequence version: 102 DIP protein Q8RQE9 original sequence version: 100 C1260F31CEC6B40D rpoz_thet8 DNA-directed RNA polymerase subunit omega rpoZ Transcriptase subunit omega RNA polymerase omega subunit TTHA1561 protein protein thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) MAEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPVEREE DIP protein Q8RQE7 original sequence version: 81 DIP protein Q8RQE7 original sequence version: 62 DIP protein Q8RQE7 original sequence version: 97 DIP protein Q8RQE7 original sequence version: 96 1D213933B0B98965 q5skw1_thet8 RNA polymerase sigma factor SigA sigA TTHA0532 protein protein thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) MKKSKRKNAQAQEAQETEVLVQEEAEELPEFPEGEPDPDLEDPDLTLEDDLLDLPEEGEGLDLEEEEEDLPIPKISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEITGLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIAREGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRFKFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQLQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQEPVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEELEKALSKLSEREAMVLKLRKGLIDGREHTLEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRDFLD DIP protein Q5SKW1 original sequence version: 67 DIP protein Q5SKW1 original sequence version: 92 DIP protein Q5SKW1 original sequence version: 88 D3A80BF9C929BD09 rpoc_thet8 DNA-directed RNA polymerase subunit beta' rpoC Transcriptase subunit beta' RNA polymerase subunit beta' TTHA1812 protein protein thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) MKKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGVALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEILAELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATYFLPVGMTPLVVHGEIVEKGQPLAEAKGLLRMPRQVRAAQVEAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGARVEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKEAVEAKERPAARRGVKREQPGKQA DIP protein Q8RQE8 original sequence version: 86 DIP protein Q8RQE8 original sequence version: 66 DIP protein Q8RQE8 original sequence version: 104 DIP protein Q8RQE8 original sequence version: 102 A7B335945B08E3A7 rpoa_thet8 DNA-directed RNA polymerase subunit alpha Transcriptase subunit alpha RNA polymerase subunit alpha TTHA1664 rpoA protein protein thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADVEIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKDRINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDGSVTPLEALNQAVEILREHLTYFSNPQAAAVAAPEEAKEPEAPPEQEEELDLPLEELGLSTRVLHSLKEEGIESVRALLALNLKDLKNIPGIGERSLEEIKEALEKKGFTLKE DIP protein Q5SHR6 original sequence version: 69 DIP protein Q5SHR6 original sequence version: 49 DIP protein Q5SHR6 original sequence version: 85 DIP protein Q5SHR6 original sequence version: 83 F79D93B57526A1CB rpoa-rpob-5 1 4 unspecified role unspecified role unspecified role unspecified role thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 3 unspecified role unspecified role unspecified role unspecified role thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 5 unspecified role unspecified role unspecified role unspecified role thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 2 unspecified role unspecified role unspecified role unspecified role thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 6 unspecified role unspecified role unspecified role unspecified role thet8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) physical association physical association