DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Structure (London, England : 1993) 2005 imex curation Huang CC., Stricher F., Martin L., Decker JM., Majeed S., Barthe P., Hendrickson WA., Robinson J., Roumestand C., Sodroski J., Wyatt R., Shaw GM., Vita C., Kwong PD. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Huang CC., Stricher F., Martin L., Decker JM., Majeed S., Barthe P., Hendrickson WA., Robinson J., Roumestand C., Sodroski J., Wyatt R., Shaw GM., Vita C., Kwong PD. DIP original experiment: DIP-132763X Structure (London, England : 1993) 2005 IMEx Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. Structure (London, England : 1993) 2005 imex curation Huang CC., Stricher F., Martin L., Decker JM., Majeed S., Barthe P., Hendrickson WA., Robinson J., Roumestand C., Sodroski J., Wyatt R., Shaw GM., Vita C., Kwong PD. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Huang CC., Stricher F., Martin L., Decker JM., Majeed S., Barthe P., Hendrickson WA., Robinson J., Roumestand C., Sodroski J., Wyatt R., Shaw GM., Vita C., Kwong PD. DIP original experiment: DIP-132762X Structure (London, England : 1993) 2005 IMEx Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth. env_hv1y2 Envelope glycoprotein gp160 env Env polyprotein protein protein hv1y2 Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) HIV-1 MRATEIRKNYQHLWKGGTLLLGMLMICSAAEQLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVKLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNATNTTSSSWETMEKGEIKNCSFNITTSIRDKVQKEYALFYNLDVVPIDNASYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEIVIRSENFTNNAKTIIVQLNESVVINCTRPNNNTRKSINIGPGRALYTTGEIIGDIRQAHCNLSKTQWENTLEQIAIKLKEQFGNNKTIIFNPSSGGDPEIVTHSFNCGGEFFYCNSTQLFTWNDTRKLNNTGRNITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGKDTNGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGLGALFLGFLGAAGSTMGAASITLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTTVPWNTSWSNKSLNEIWDNMTWMKWEREIDNYTHIIYSLIEQSQNQQEKNEQELLALDKWASLWNWFDITKWLWYIKIFIMIVGGLIGLRIVFVVLSIVNRVRQGYSPLSFQTHLPAQRGPDRPDGIEEEGGERDRDRSGPLVDGFLAIIWVDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWGVLKYWWNLLQYWIQELKNSAVSLLNATAIAVAEGTDRVIEILQRAFRAVLHIPVRIRQGLERALL DIP protein P35961 original sequence version: 80 C69DFD971C918B71 cd4m33/f23 Scorpion-toxin mimic of CD4 peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) NLHFCQLRCKSLGLLGKCAGSFCACV cd4m33/f23-env-1 2 4 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 3 unspecified role unspecified role unspecified role unspecified role gp120 core domain Region 82-479 polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly direct interaction direct interaction cd4m33/f23-env-2 1 4 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 3 unspecified role unspecified role unspecified role unspecified role gp120 core domain Region 82-479 polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly direct interaction direct interaction