MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD. Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD. FEBS letters 2016 imex curation Mizuguchi M., Obita T., Kajiyama A., Kozakai Y., Nakai T., Nabeshima Y., Okazawa H. mineyuki@pha.u-toyama.ac.jp 8-Jun-2017: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Mizuguchi M., Obita T., Kajiyama A., Kozakai Y., Nakai T., Nabeshima Y., Okazawa H. mineyuki@pha.u-toyama.ac.jp Accepted 2017-MAY-08 AT 08:48 BST AT 08:48 BST by LUANA FEBS letters 2016 imex curation wbp11_human WW domain-binding protein 11 SH3 domain-binding protein SNP70 Npw38-binding protein WBP11 NPWBP SNP70 SIPP1 Splicing factor that interacts with PQBP-1 and PP1 protein protein human Homo sapiens Human MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKSEDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL C94F9687D132CE77 pqbp1_human Polyglutamine-binding protein 1 Polyglutamine tract-binding protein 1 38 kDa nuclear protein containing a WW domain PQBP1 JM26 NPW38 protein protein human Homo sapiens Human MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRSHEKLDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD 98C3BEF18CFF0297 1-116 1 2 unspecified role unspecified role prey prey purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2 t1 pqbp1-wbp11-3 1 2 unspecified role unspecified role prey prey purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2b t1 pqbp1-wbp11-4 1 2 unspecified role unspecified role prey prey purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9Y2W2:p.Pro455_Leu458delinsAlaAlaAlaAla mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain PRLL AAAA Wed May 02 16:52:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro_arg_leu_leu455-458ala_ala_ala_ala' Tue Jun 30 17:39:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro455_Leu458delinsAlaAlaAlaAla' 3 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2b t1 pqbp1-wbp11-5 1 2 unspecified role unspecified role prey prey purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9Y2W2:p.Pro459_Gly461delinsAlaAlaAla mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain PPG AAA Wed May 02 20:14:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro_pro_gly459-461ala_ala_ala' Tue Jun 30 19:09:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro459_Gly461delinsAlaAlaAla' 3 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2b t1 pqbp1-wbp11-6 1 2 unspecified role unspecified role prey prey purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9Y2W2:p.Pro462_Gly465delinsAlaAlaAlaAla mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain PPPG AAAA Wed May 02 18:58:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro_pro_pro_gly462-465ala_ala_ala_ala' Tue Jun 30 20:19:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro462_Gly465delinsAlaAlaAlaAla' 3 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2b t1 pqbp1-wbp11-7 1 2 unspecified role unspecified role prey prey purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9Y2W2:p.Arg466_Gly469delinsAlaAlaAlaAla mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain RPPG AAAA Tue Jan 24 14:08:44 GMT 2017 This feature has been corrected as a result of our quality control procedures. The original label was 'arg_pro_pro_gly465-469ala_ala_ala_ala' Wed May 02 14:35:38 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg_pro_pro_gly466-469ala_ala_ala_ala' Tue Jun 30 16:28:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg466_Gly469delinsAlaAlaAlaAla' 3 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2b t1a pqbp1-wbp11-8 1 2 unspecified role unspecified role bait bait purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role prey prey purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f3a t2 wbp11-pqbp1-1 1 2 unspecified role unspecified role bait bait purified purified binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain lipoyl domain tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 unspecified role unspecified role prey prey purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain O60828:p.Tyr65Cys mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain Y C Wed May 02 19:51:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr65cys' Tue Jun 30 18:17:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr65Cys' O60828:p.Val73Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain V A Wed May 02 14:25:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val73ala' Tue Jun 30 17:42:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val73Ala' O60828:p.Trp66Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain W A Wed May 02 18:49:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp66ala' Tue Jun 30 16:07:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp66Ala' O60828:p.Tyr64Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain Y A Wed May 02 20:10:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr64ala' Tue Jun 30 15:48:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr64Ala' O60828:p.Trp75Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain W A Wed May 02 17:12:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp75ala' Tue Jun 30 15:40:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp75Ala' direct interaction direct interaction f3c f3d t2