MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3. Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3. FEBS letters 2016 imex curation Alam MS., Rathore S., Tyagi RK., Sharma YD. ydsharma_aiims@yahoo.com 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro elisa enzyme linked immunosorbent assay ELISA ELISA elisa antibody detection identification by antibody antibody detection Alam MS., Rathore S., Tyagi RK., Sharma YD. ydsharma_aiims@yahoo.com Accepted 2016-MAR-30 AT 11:18 BST AT 11:18 BST by MARTA FEBS letters 2016 Only protein-protein interactions imex curation imex curation Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3. Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3. FEBS letters 2016 imex curation Alam MS., Rathore S., Tyagi RK., Sharma YD. ydsharma_aiims@yahoo.com 11-Apr-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Alam MS., Rathore S., Tyagi RK., Sharma YD. ydsharma_aiims@yahoo.com Accepted 2016-MAR-30 AT 11:18 BST AT 11:18 BST by MARTA FEBS letters 2016 Only protein-protein interactions imex curation imex curation a5k5e5_plavs PVX_088820 protein protein Plasmodium vivax (strain Salvador I) Plasmodium vivax (strain Salvador I) MELKKNNAALTSQRSSSRTTSTRSYKNAPKNSTSFLSRLSILIFALSCAIFVNTASGAAANRPNANGFVSPTLIGFGELSIQESEEFKRMAWNNWMLRLESDWKHFNDSVEEAKTKWLHERDSAWSDWLRSLQSKWSHYSEKMLKEHKSNVMEKSANWNDTQWGNWIKTEGRKILEAQWEKWIKKGDDQLQKLILDKWVQWKNDKIRSWLSSEWKTEEDYYWANVERATTAKWLQEAEKMHWLKWKERINRESEQWVNWVQMKESVYINVEWKKWPKWKNDKKILFNKWSTNLVYKWTLKKQWNVWIKEANTAPQV 5AAF5C3BA40FD9F1 b3at_human Band 3 anion transport protein SLC4A1 AE1 DI EPB3 Anion exchange protein 1 Solute carrier family 4 member 1 protein protein human Homo sapiens Human MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590] Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin mint Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal 35EC3EE7AFF27D2F slc4a1-a5k5e5_plavs-1 1 4 predetermined predetermined participant predetermined antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait purified purified 3 unspecified role unspecified role prey prey purified purified his tag his tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A5K5E5:p.[Lys197Ala;Trp198Ala;Val199Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain W A certain certain sequence position certain certain certain sequence position certain V A Fri Jul 22 10:58:25 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'lys_trp_val197-199ala_ala_ala' Wed May 02 18:43:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys197ala,trp198ala,val199ala' Tue Jun 30 15:48:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys197Ala;Trp198Ala;Val199Ala]' A5K5E5:p.[Gln200Ala;Trp201Ala;Lys202Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain Q A certain certain sequence position certain certain certain sequence position certain W A certain certain sequence position certain certain certain sequence position certain K A Fri Jul 22 10:54:57 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'gln_trp_lys200-202ala_ala_ala' Wed May 02 16:33:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln200ala,trp201ala,lys202ala' Tue Jun 30 18:02:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln200Ala;Trp201Ala;Lys202Ala]' A5K5E5:p.[Asn203Ala;Asp204Ala;Lys205Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain D A Fri Jul 22 11:03:18 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'asn_asp_lys203-205ala_ala_ala' Wed May 02 14:30:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn203ala,asp204ala,lys205ala' Tue Jun 30 19:49:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Asn203Ala;Asp204Ala;Lys205Ala]' A5K5E5:p.[Ile206Ala;Arg207Ala;Ser208Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain I A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain R A Fri Jul 22 11:09:39 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'ile_arg_ser206-208ala_ala_ala' Wed May 02 14:47:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile206ala,arg207ala,ser208ala' Tue Jun 30 19:00:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ile206Ala;Arg207Ala;Ser208Ala]' A5K5E5:p.[Ser212Ala;Glu213Ala;Trp214Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain E A certain certain sequence position certain certain certain sequence position certain W A Fri Jul 22 10:57:02 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'ser_glu_trp212-214ala_ala_ala' Wed May 02 17:39:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser212ala,glu213ala,trp214ala' Tue Jun 30 17:41:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser212Ala;Glu213Ala;Trp214Ala]' direct interaction direct interaction t1 slc4a1-a5k5e5_plavs-2 1 4 predetermined predetermined participant predetermined antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait purified purified 3 unspecified role unspecified role prey prey purified purified his tag his tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain N A Wed May 02 16:03:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn203ala' Tue Jun 30 15:55:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn203Ala' A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain V A Wed May 02 18:12:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val199ala' Tue Jun 30 17:48:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val199Ala' A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R A Wed May 02 14:58:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg207ala' Tue Jun 30 16:01:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg207Ala' direct interaction direct interaction t2 slc4a1-a5k5e5_plavs-3 1 4 unspecified role unspecified role prey prey purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain trx tag tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 predetermined predetermined participant predetermined antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait purified purified A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain V A Wed May 02 16:22:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val199ala' Tue Jun 30 20:18:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val199Ala' range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2a a5k5e5_plavs-slc4a1-1 1 4 unspecified role unspecified role prey prey purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain trx tag tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 predetermined predetermined participant predetermined antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait purified purified A5K5E5:p.Lys197Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain K A Wed May 02 18:33:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys197ala' Tue Jun 30 20:19:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys197Ala' range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2b a5k5e5_plavs-slc4a1-2 1 4 unspecified role unspecified role prey prey purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain trx tag tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 3 predetermined predetermined participant predetermined antibody detection identification by antibody antibody detection unspecified role unspecified role bait bait purified purified A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain N A Wed May 02 17:08:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn203ala' Tue Jun 30 19:41:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn203Ala' range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain direct interaction direct interaction f2c a5k5e5_plavs-slc4a1-3 2 4 unspecified role unspecified role bait bait purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain 3 unspecified role unspecified role prey prey purified purified A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain N A Wed May 02 18:36:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn203ala' Tue Jun 30 20:03:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn203Ala' range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A5K5E5:p.Trp201Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain W A Wed May 02 20:01:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp201ala' Tue Jun 30 19:09:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp201Ala' A5K5E5:p.Trp198Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain W A Wed May 02 14:56:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp198ala' Tue Jun 30 16:41:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp198Ala' A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R A Wed May 02 18:58:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg207ala' Tue Jun 30 19:42:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg207Ala' direct interaction direct interaction t3 slc4a1-a5k5e5_plavs-4 2 4 unspecified role unspecified role bait bait purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain 3 unspecified role unspecified role prey prey purified purified A5K5E5:p.Lys197Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain K A Wed May 02 19:07:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys197ala' Tue Jun 30 15:52:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys197Ala' range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain V A Wed May 02 19:07:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val199ala' Tue Jun 30 18:17:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val199Ala' A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R A Wed May 02 14:25:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg207ala' Tue Jun 30 16:53:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg207Ala' direct interaction direct interaction t3 slc4a1-a5k5e5_plavs-5 2 4 unspecified role unspecified role bait bait purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain 3 unspecified role unspecified role prey prey purified purified A5K5E5:p.Gln200Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain Q A Wed May 02 19:20:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln200ala' Tue Jun 30 19:06:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln200Ala' range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain V A Wed May 02 16:09:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val199ala' Tue Jun 30 18:18:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val199Ala' A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R A Wed May 02 17:36:44 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg207ala' Tue Jun 30 17:24:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg207Ala' A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain N A Wed May 02 14:29:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn203ala' Tue Jun 30 17:21:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn203Ala' A5K5E5:p.Lys202Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain K A Wed May 02 15:11:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys202ala' Tue Jun 30 19:58:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys202Ala' A5K5E5:p.Lys205Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain K A Wed May 02 14:41:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys205ala' Tue Jun 30 20:03:42 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys205Ala' direct interaction direct interaction t3