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  <entry>
    <source releaseDate="2022-02-04">
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        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Epithelial-specific ETS-1 (ESE1/ELF3) regulates apoptosis of intestinal epithelial cells in ulcerative colitis via accelerating NF-κB activation.</fullName>
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            <attribute name="publication title" nameAc="MI:1091">Epithelial-specific ETS-1 (ESE1/ELF3) regulates apoptosis of intestinal epithelial cells in ulcerative colitis via accelerating NF-κB activation.</attribute>
            <attribute name="journal" nameAc="MI:0885">Immunologic research</attribute>
            <attribute name="publication year" nameAc="MI:0886">2015</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Li L., Miao X., Ni R., Miao X., Wang L., Gu X., Yan L., Tang Q., Zhang D.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">tqy831@163.com</attribute>
            <attribute name="author-announcement">22-Feb-2016: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-ht_29</shortLabel>
              <fullName>Homo sapiens HT-29 caucasian women with colon adenocarcinoma</fullName>
            </names>
            <cellType>
              <names>
                <shortLabel>ht_29</shortLabel>
                <fullName>HT-29</fullName>
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              <attributeList>
                <attribute name="comment" nameAc="MI:0612">confirmed as human with IEF of AST, LDH established from the primary tumor of a 44-year-old Caucasian woman with colon adenocarcinoma in 1964; described to be heterotransplantable forming well-differentiated grade I tumors</attribute>
              </attributeList>
            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>fluorescence imaging</shortLabel>
            <fullName>fluorescence microscopy</fullName>
            <alias type="synonym" typeAc="MI:1041">fluorescence imaging</alias>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>immunocytochemistry</shortLabel>
            <fullName>immunocytochemistry</fullName>
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            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1200" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Li L., Miao X., Ni R., Miao X., Wang L., Gu X., Yan L., Tang Q., Zhang D.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">tqy831@163.com</attribute>
          <attribute name="accepted">Accepted 2016-FEB-16 AT 08:15 GMT AT 08:15 GMT by ORCHARD</attribute>
          <attribute name="journal" nameAc="MI:0885">Immunologic research</attribute>
          <attribute name="publication year" nameAc="MI:0886">2015</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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      </experimentDescription>
      <experimentDescription id="2">
        <names>
          <fullName>Epithelial-specific ETS-1 (ESE1/ELF3) regulates apoptosis of intestinal epithelial cells in ulcerative colitis via accelerating NF-κB activation.</fullName>
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            <attribute name="publication title" nameAc="MI:1091">Epithelial-specific ETS-1 (ESE1/ELF3) regulates apoptosis of intestinal epithelial cells in ulcerative colitis via accelerating NF-κB activation.</attribute>
            <attribute name="journal" nameAc="MI:0885">Immunologic research</attribute>
            <attribute name="publication year" nameAc="MI:0886">2015</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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            <attribute name="author-list" nameAc="MI:0636">Li L., Miao X., Ni R., Miao X., Wang L., Gu X., Yan L., Tang Q., Zhang D.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">tqy831@163.com</attribute>
            <attribute name="author-announcement">22-Feb-2016: Contacted by IntAct-Help.</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-ht_29</shortLabel>
              <fullName>Homo sapiens HT-29 caucasian women with colon adenocarcinoma</fullName>
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                <shortLabel>ht_29</shortLabel>
                <fullName>HT-29</fullName>
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            </cellType>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
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        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
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        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Li L., Miao X., Ni R., Miao X., Wang L., Gu X., Yan L., Tang Q., Zhang D.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">tqy831@163.com</attribute>
          <attribute name="accepted">Accepted 2016-FEB-16 AT 08:15 GMT AT 08:15 GMT by ORCHARD</attribute>
          <attribute name="journal" nameAc="MI:0885">Immunologic research</attribute>
          <attribute name="publication year" nameAc="MI:0886">2015</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
          <attribute name="correction comment"/>
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      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>elf3_human</shortLabel>
          <fullName>ETS-related transcription factor Elf-3</fullName>
          <alias type="gene name" typeAc="MI:0301">ELF3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ERT</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ESX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">JEN</alias>
          <alias type="gene name synonym" typeAc="MI:0302">E74-like factor 3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Epithelium-specific Ets transcription factor 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Epithelium-restricted Ets protein ESX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Epithelial-restricted with serine box</alias>
        </names>
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          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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        </interactorType>
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            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
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        </organism>
        <sequence>MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTLSNPQMSLEGTEKASWLGEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGATLCNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMAFQEALDPGPFDQGSPFAQELLDDGQQASPYHPGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSDGFRDCKKGDPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVLQSRN</sequence>
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          <attribute name="crc64">81A23A7DECBE2EF9</attribute>
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      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>tf65_human</shortLabel>
          <fullName>Transcription factor p65</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Nuclear factor NF-kappa-B p65 subunit</alias>
          <alias type="gene name" typeAc="MI:0301">RELA</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NFKB3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3</alias>
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        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 170</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 173</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 99</attribute>
          <attribute name="remark-internal">DIP protein Q04206-1 original sequence version: 99</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 168</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 128</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 131</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 153</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 185</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 181</attribute>
          <attribute name="remark-internal">DIP protein Q04206 original sequence version: 183</attribute>
          <attribute name="crc64">8147A6AF9F2445C6</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5" imexId="IM-25019-1">
        <names>
          <shortLabel>elf3-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-11560050" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25019-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Fig. 6D</attribute>
          <attribute name="comment" nameAc="MI:0612">Cells were treated with TNF-alpha</attribute>
        </attributeList>
      </interaction>
      <interaction id="8" imexId="IM-25019-2">
        <names>
          <shortLabel>elf3-rela-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-11575560" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" refType="component" refTypeAc="MI:0354"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25019-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="10">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>colocalization</shortLabel>
            <fullName>colocalization</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Fig. 6C</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>