IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Genome-wide searching for pseudouridylation guide snoRNAs: analysis of the Saccharomyces cerevisiae genome. Genome-wide searching for pseudouridylation guide snoRNAs: analysis of the Saccharomyces cerevisiae genome. Nucleic acids research 2003 imex curation Schattner P., Decatur WA., Davis CA., Ares M., Fournier MJ., Lowe TM. schattner@cse.ucsc.edu 04-Aug-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation yeast Saccharomyces cerevisiae Baker's yeast chemical rna modification plus base pairing prediction chemical rna modification plus base pairing prediction chemical rna modification plus base pairing prediction primer extension assay primer extension assay primer extension assay Schattner P., Decatur WA., Davis CA., Ares M., Fournier MJ., Lowe TM. Primer extension assay was performed after treating RNA with CMC to detect pseudouridines schattner@cse.ucsc.edu Accepted 2016-JUL-07 AT 08:30 BST AT 08:30 BST by MGT Nucleic acids research 2003 imex curation snr 161 yeast small nucleolar RNA 161 Yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast UAAAUAUACAACACCCAGUAUUUUUGGCUGCCCGUGUCUUUCUCUACCACGGGUAGUCUCUCUAAGCUGGCAGAUAGAUGUUUAUUGAACCGCUUAAGUUCCGUUGUGAAGUUUUCGUCUUUCAGGCUGUAUUUCAUAACACUACUGUAGUUCACACAUAC rrna 25s yeast Ribosomal RNA 25S Yeast rrna ribosomal rna rRNA rrna yeast Saccharomyces cerevisiae Baker's yeast GUUUGACCUCAAAUCAGGUAGGAGUACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGAAAAGAAACCAACCGGGAUUGCCUUAGUAACGGCGAGUGAAGCGGCAAAAGCUCAAAUUUGAAAUCUGGUACCUUCGGUGCCCGAGUUGUAAUUUGGAGAGGGCAACUUUGGGGCCGUUCCUUGUCUAUGUUCCUUGGAACAGGACGUCAUAGAGGGUGAGAAUCCCGUGUGGCGAGGAGUGCGGUUCUUUGUAAAGUGCCUUCGAAGAGUCGAGUUGUUUGGGAAUGCAGCUCUAAGUGGGUGGUAAAUUCCAUCUAAAGCUAAAUAUUGGCGAGAGACCGAUAGCGAACAAGUACAGUGAUGGAAAGAUGAAAAGAACUUUGAAAAGAGAGUGAAAAAGUACGUGAAAUUGUUGAAAGGGAAGGGCAUUUGAUCAGACAUGGUGUUUUGUGCCCUCUGCUCCUUGUGGGUAGGGGAAUCUCGCAUUUCACUGGGCCAGCAUCAGUUUUGGUGGCAGGAUAAAUCCAUAGGAAUGUAGCUUGCCUCGGUAAGUAUUAUAGCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACGUAAGUCAAGGAUGCUGGCAUAAUGGUUAUAUGCCGCCCGUCUUGAAACACGGACCAAGGAGUCUAACGUCUAUGCGAGUGUUUGGGUGUAAAACCCAUACGCGUAAUGAAAGUGAACGUAGGUUGGGGCCUCGCAAGAGGUGCACAAUCGACCGAUCCUGAUGUCUUCGGAUGGAUUUGAGUAAGAGCAUAGCUGUUGGGACCCGAAAGAUGGUGAACUAUGCCUGAAUAGGGUGAAGCCAGAGGAAACUCUGGUGGAGGCUCGUAGCGGUUCUGACGUGCAAAUCGAUCGUCGAAUUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCUGCCGAAGUUUCCCUCAGGAUAGCAGAAGCUCGUAUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUUCCGGGGUCGAAAUGACCUUGACCUAUUCUCAAACUUUAAAUAUGUAAGAAGUCCUUGUUACUUAAUUGAACGUGGACAUUUGAAUGAAGAGCUUUUAGUGGGCCAUUUUUGGUAAGCAGAACUGGCGAUGCGGGAUGAACCGAACGUAGAGUUAAGGUGCCGGAAUACACGCUCAUCAGACACCACAAAAGGUGUUAGUUCAUCUAGACAGCCGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCGGCCGAAUGAACUAGCCCUGAAAAUGGAUGGCGCUCAAGCGUGUUACCUAUACUCUACCGUCAGGGUUGAUAUGAUGCCCUGACGAGUAGGCAGGCGUGGAGGUCAGUGACGAAGCCUAGACCGUAAGGUCGGGUCGAACGGCCUCUAGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAAUGAGAACUUUGAAGACUGAAGUGGGGAAAGGUUCCACGUCAACAGCAGUUGGACGUGGGUUAGUCGAUCCUAAGAGAUGGGGAAGCUCCGUUUCAAAGGCCUGAUUUUAUGCAGGCCACCAUCGAAAGGGAAUCCGGUUAAGAUUCCGGAACCUGGAUAUGGAUUCUUCACGGUAACGUAACUGAAUGUGGAGACGUCGGCGCGAGCCCUGGGAGGAGUUAUCUUUUCUUCUUAACAGCUUAUCACCCCGGAAUUGGUUUAUCCGGAGAUGGGGUCUUAUGGCUGGAAGAGGCCAGCACCUUUGCUGGCUCCGGUGCGCUUGUGACGGCCCGUGAAAAUCCACAGGAAGGAAUAGUUUUCAUGCCAGGUCGUACUGAUAACCGCAGCAGGUCUCCAAGGUGAACAGCCUCUAGUUGAUAGAAUAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGUAACUUCGGGAUAAGGAUUGGCUCUAAGGGUCGGGUAGUGAGGGCCUUGGUCAGACGCAGCGGGCGUGCUUGUGGACUGCUUGGUGGGGCUUGCUCUGCUAGGCGGACUACUUGCGUGCCUUGUUGUAGACGGCCUUGGUAGGUCUCUUGUAGACCGUCGCUUGCUACAAUUAACGAUCAACUUAGAACUGGUACGGACAAGGGGAAUCUGACUGUCUAAUUAAAACAUAGCAUUGCGAUGGUCAGAAAGUGAUGUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUUAACGAGAUUCCCACUGUCCCUAUCUACUAUCUAGCGAAACCACAGCCAAGGGAACGGGCUUGGCAGAAUCAGCGGGGAAAGAAGACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGAAGAGACAUAGAGGGUGUAGAAUAAGUGGGAGCUUCGGCGCCAGUGAAAUACCACUACCUUUAUAGUUUCUUUACUUAUUCAAUGAAGCGGAGCUGGAAUUCAUUUUCCACGUUCUAGCAUUCAAGGUCCCAUUCGGGGCUGAUCCGGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUAAACGAUAACGCAGAUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUAGAACAAAAGGGUAAAAGCCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACCAUGAAAGUGUGGCCUAUCGAUCCUUUAGUCCCUCGGAAUUUGAGGCUAGAGGUGCCAGAAAAGUUACCACAGGGAUAACUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUCGAUGUCGGCUCUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAAUGUUACCGCAAUAGUAAUUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAUAAUUGGUUUUUGCGGCUGUCUGAUCAGGCAUUGCCGCGAAGCUACCAUCCGCUGGAUUAUGGCUGAACGCCUCUAAGUCAGAAUCCAUGCUAGAACGCGGUGAUUUCUUUGCUCCACACAAUAUAGAUGGAUACGAAUAAGGCGUCCUUGUGGCGUCGCUGAACCAUAGCAGGCUAGCAACGGUGCACUUGGCGGAAAGGCCUUGGGUGCUUGCUGGCGAAUUGCAAUGUCAUUUUGCGUGGGGAUAAAUCAUUUGUAUACGACUUAGAUGUACAACGGGGUAUUGUAAGCAGUAGAGUAGCCUUGUUGUUACGAUCUGCUGAGAUUAAGCCUUUGUUGUCUGAUUUGU snr83 yeast small nucleolar RNA 83 yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast ACCCAAAAACAUCAAGAAAAGCCUUUCAAUAAAUUGCUCUUCUCUUGGCGAAAGAAAGCGGGGGGCAAAAAGAAUCACGGGACUUAUGUUUCGGGAUCUCUUUGUUUCUUCUUUUUUUCCCGGAGAAUAAUUUUUUAGGACCAAUUACCGUAGUUGCGACUACAACAAUUGUUGUUCAUACCCCCACGAUUUACUUUUUGAAAACUAGUUUUUGGAAUAAUAAUGUUGUAAAAUUUCCCUUUUUCCACCCCGAUUUGUAUUUUAUUUUUCGUUACAAAAUUGGGACUAAUAUUAAGGGCGACAGUU snr81 yeast small nucleolar RNA 81 yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast AGGUUAGGGACUGCAAAAGAAGCGGCGAGGCAGCCCACAUCAAGUGGAACUACACAGACUUCCUUGUCGCGAUACUACGGUCCCAAGAGCAAUCCUAACAAGCAAUUACAUAUUCCCCCGCUGAACCUGUACAGUCCACGGAUGGUGCAGAAGUUAUAUGAUUUGGGGGAAGACGCUUUUUCACAUCUUCUUGCAUGAUAA snr189 yeast small nucleolar RNA 189 snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast AACAAAAUAAUUUACAUUCCAAGGACCGGUAUUAUUGUAGGGGAUUUGUGACUUUCAAGGCAACGUCCUCUCUACAACCGAGUUCGAGAAUAAGUACAAAUGGCUCUUUUUGUUAUUCGAAAGCUUACAAGUUCUGGUAUAUUCUAUAUACUCACUUAUUACUUUCAAGUACUUCACACGGGCCUGACA snr80 yeast small nuclear RNA 80 snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast GAACGUUUGACAACACUCUGGGACCAAGUUUCGAUGGUUAUUUUUUUAUUUCCAUCGAUGUCUUUCACUGUACUUAGUUCCAAUUUAUAUUGCAAACAAGAUUAAUUUAGGCGAUUACUCACUAAGAUAUACCUAUUUCUACUAUGGUUAUAUUAGUCCAUUUCAUAGCCU rrna 18s yeast Ribosomal RNA 18S Yeast rrna ribosomal rna rRNA rrna yeast Saccharomyces cerevisiae Baker's yeast UAUCUGGUUGAUCCUGCCAGUAGUCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUAAGUAUAAGCAAUUUAUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUCGUUUAUUUGAUAGUUCCUUUACUACAUGGUAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCUUAAAAUCUCGACCCUUUGGAAGAGAUGUAUUUAUUAGAUAAAAAAUCAAUGUCUUCGGACUCUUUGAUGAUUCAUAAUAACUUUUCGAAUCGCAUGGCCUUGUGCUGGCGAUGGUUCAUUCAAAUUUCUGCCCUAUCAACUUUCGAUGGUAGGAUAGUGGCCUACCAUGGUUUCAACGGGUAACGGGGAAUAAGGGUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCGCGCAAAUUACCCAAUCCUAAUUCAGGGAGGUAGUGACAAUAAAUAACGAUACAGGGCCCAUUCGGGUCUUGUAAUUGGAAUGAGUACAAUGUAAAUACCUUAACGAGGAACAAUUGGAGGGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUCGUAGUUGAACUUUGGGCCCGGUUGGCCGGUCCGAUUUUUUCGUGUACUGGAUUUCCAACGGGGCCUUUCCUUCUGGCUAACCUUGAGUCCUUGUGGCUCUUGGCGAACCAGGACUUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCGUAUUGCUCGAAUAUAUUAGCAUGGAAUAAUAGAAUAGGACGUUUGGUUCUAUUUUGUUGGUUUCUAGGACCAUCGUAAUGAUUAAUAGGGACGGUCGGGGGCAUCAGUAUUCAAUUGUCAGAGGUGAAAUUCUUGGAUUUAUUGAAGACUAACUACUGCGAAAGCAUUUGCCAAGGACGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCGAAGAUGAUCAGAUACCGUCGUAGUCUUAACCAUAAACUAUGCCGACUAGGGAUCGGGUGGUGUUUUUUUAAUGACCCACUCGGCACCUUACGAGAAAUCAAAGUCUUUGGGUUCUGGGGGGAGUAUGGUCGCAAGGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAAACUCACCAGGUCCAGACACAAUAAGGAUUGACAGAUUGAGAGCUCUUUCUUGAUUUUGUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGUGAUUUGUCUGCUUAAUUGCGAUAACGAACGAGACCUUAACCUACUAAAUAGUGGUGCUAGCAUUUGCUGGUUAUCCACUUCUUAGAGGGACUAUCGGUUUCAAGCCGAUGGAAGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGACGUUCUGGGCCGCACGCGCGCUACACUGACGGAGCCAGCGAGUCUAACCUUGGCCGAGAGGUCUUGGUAAUCUUGUGAAACUCCGUCGUGCUGGGGAUAGAGCAUUGUAAUUAUUGCUCUUCAACGAGGAAUUCCUAGUAAGCGCAAGUCAUCAGCUUGCGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGUCGCUAGUACCGAUUGAAUGGCUUAGUGAGGCCUCAGGAUCUGCUUAGAGAAGGGGGCAACUCCAUCUCAGAGCGGAGAAUUUGGACAAACUUGGUCAUUUAGAGGAACUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGGAUCAUUA snr49 yeast small nuclear RNA 49 snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast ACUUUAUCUCCAUGACUAUGCCAUUUCUAGGUAGCCUAUGGUAAACGAAUCCCGUAGAUUAUUCACACGUUUGUUGUCUUUGUUGACAACAACACAGAGUAAGAAAAAGCAAAAGAUUUAUCUCUUUUGUCCAUCUUUUUUUUAUUUUGAAGGCGUGUAACAUUU snr 44 yeast small nucleolar RNA 44 Yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast UCCGGGCUGAUAACUAGAUGGUGUGAUCGGGCAGUAUACUAAUUUAUACUGGACAAAGACUCGUAAAAGAUGUUCUUUGUGCUUAGUCCCAUACUGUUUUUUAAGUGUCCGGGAUAUUUAAUCCCAUGUGGAAAUGCUUCUUACACGGUUAUGGAUUACACCUCAUGUGUAGCUACUAUAUCCAUUACCGUUUACUUUUCCUCAAAAUCUC snr84 yeast small nucleolar RNA 84 yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast AUUGCACAACUUAAGUUUGUCGAGGAUCAUUUUUUUGAACUGAAUCAUGCUCUUUUUAAGUGCUUUGAAACCCUCGAUGAAUGUGUCAAUGUGCAAAGAUAAACCAUUGUUCUCUGUUGAUCAGUGACUUAAUGUUUGCUUUGGAGAAUGAUAUUUUCCCUUUCCUAUAUUUGACUUUUGUUCUAAAAGUUAUUUGGAGAGAAAAGGCAUGAUUGAGGUUGCGACUUUUUCGUUUUUGCUUUUGCAUGGAUAAUUCAUCCAUGCACAUCUCACUUUAUUGGACCUUCAAGAUUGGUUUCCCAUGUAAUUUAAUUUUCUCUCCUCUACAUUUAAUAUGUUCUAUAUUAAUUAAUACCAAUUGAGUUGUGCGUACUUCAUUGCAGAUAUUUUACCAGACCUGUCUGAGUUUUUCGUUCAAGUUUGGUUGAAAUCGGCUUGAGGUAUAUGAACGUGGUUGGGAUAUGGAGAUUGGGAGAUCAAAGAAGCGAAAAUACCUGAGACAGUUUUUUUAAAAAAGAAGCUAAGGAACAUGACUCAAAGAGACACAUUA snr3 yeast small nucleolar RNA 3 yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast AACUUUGUCCUAAAGUACUAAUCCACCGCAUUAGACAGUACGAAGAUCGAGCUAUUUAUUUGAACACUCGGUCUUAUUCGUGAUAAGCGUAAUGUGGAGAGAUCAAUUUCCGGGUCAUUUAUAAGAACUCGAGUGGAUUGCUAGUUGUUUUGAUUAGCUGAAUGAGACUCGAGUGUCAGAAGAUGACUAUAUUU snr82 yeast small nucleolar RNA 82 yeast snorna small nucleolar rna snoRNA snorna yeast Saccharomyces cerevisiae Baker's yeast AUGGCUCUUCAACACAUUUCAACAUGUUCAAGUAAUUUGUGUUAGUGGAUGACCAUUUAGGGGCUGCUGGCCUGGUUACCGGGAGUUUUUCUUGGAUCCAAGCUAGCUUUUCCGUCUGAUUAUCCUUAAGCUUCACAAAUUACAAUUUUUCCCACGCAUUAAGAAAUAAGCUCAAGAUGCCUAAAAUAAGUUCUAUCCCGCCUUUUUUCGCUAACAAUGACUGAGUAUUCCCACAGUCUAUAGUUUGAUAGUAGAUGGGCGGAAAUUU snr80_rrna25-1 1 7 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5A, Tab4 rrna 25s yeast-snr81 yeast-2 1 5 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5A, Tab4 rrna 25s yeast-snr82 yeast-1 1 13 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5A, Tab4 rrna 25s yeast-snr84 yeast-1 1 11 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5A, Tab4 snr83_rrna18s-1 1 4 unspecified role unspecified role neutral component neutral component 8 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5A, Tab4 rrna 18s yeast-snr 161 yeast-1 1 2 unspecified role unspecified role neutral component neutral component 8 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5A, Tab4 rrna 18s yeast-snr 44 yeast-1 1 10 unspecified role unspecified role neutral component neutral component 8 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5B, Tab4 rrna 18s yeast-snr49 yeast-1 1 8 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain 9 unspecified role unspecified role neutral component neutral component physical association physical association Fig5B, Tab 4 rrna 18s yeast-snr189 yeast-1 1 6 unspecified role unspecified role neutral component neutral component 8 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5B, Tab4 rrna 25s yeast-snr81 yeast-1 1 9 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5B, Tab4 rrna 25s yeast-snr 44 yeast-1 1 10 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5B, Tab4 rrna 25s yeast-snr3 yeast-1 1 12 unspecified role unspecified role neutral component neutral component 3 unspecified role unspecified role neutral component neutral component Pseudouridine rna chemical modification RNA chemical modification RNA chemical modification post-transcriptional modification rna chemical modification certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain physical association physical association Fig 5B, Tab4