UniProt UniProt http://www.uniprot.org Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. J. Biol. Chem. (0021-9258) 1996 imex curation Bharadwaj D., Iino M., Kontoyianni M., Smith K.J., Foster D.C., Kisiel W. Origin of recombinant products according pmids 2611233 (F7) and 8555184 (TF) n/a 10-Mar-2014: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro elisa enzyme linked immunosorbent assay ELISA ELISA elisa antibody detection identification by antibody antibody detection Bharadwaj D., Iino M., Kontoyianni M., Smith K.J., Foster D.C., Kisiel W. Origin of recombinant products according pmids 2611233 (F7) and 8555184 (TF) n/a Accepted 2014-MAR-03 by ORCHARD J. Biol. Chem. (0021-9258) 1996 imex curation fa7_human Coagulation factor VII F7 Serum prothrombin conversion accelerator Proconvertin protein protein human Homo sapiens Human MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP DIP protein P08709 original sequence version: 221 9B5D501669D67B06 tf_human Tissue factor F3 Coagulation factor III Thromboplastin protein protein human Homo sapiens Human METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS DIP protein P13726 original sequence version: 170 DIP protein P13726 original sequence version: 179 D3486C713ED8EAD0 f3-f7-8 1 2 unspecified role unspecified role prey prey purified purified 3 unspecified role unspecified role bait bait purified purified n-terminal sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast direct interaction direct interaction 4 7.6 nM (wildtype F7) f3-f7-9 1 3 unspecified role unspecified role bait bait purified purified n-terminal sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 unspecified role unspecified role prey prey purified purified P08709:p.Phe388Ser mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain F S Wed May 02 15:18:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe388ser' Tue Jun 30 17:01:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe388Ser' Linked to FA7D. UniProt FTId: VAR_065413 mesau-bhk Mesocricetus auratus baby kidney cell line BHK bhk Golden (Syrian) Hamster baby kidney cell line BHK Established from the kidneys of five unsexed, one-day-old hamsters in 1961. direct interaction direct interaction 4 15.9 nM (for F7 F388S)