MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. (0261-4189) 2014 imex curation Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu,jat@scripps.edu 05-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu; jat@scripps.edu tpaull@mail.utexas.edu,jat@scripps.edu Accepted 2014-DEC-02 by MARTA EMBO J. (0261-4189) 2014 Only protein-protein interactions imex curation ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. (0261-4189) 2014 imex curation Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu,jat@scripps.edu 05-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro saxs x ray scattering saxs predetermined predetermined participant predetermined Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu; jat@scripps.edu tpaull@mail.utexas.edu,jat@scripps.edu Accepted 2014-DEC-02 by MARTA EMBO J. (0261-4189) 2014 Only protein-protein interactions imex curation ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. (0261-4189) 2014 imex curation Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu,jat@scripps.edu 05-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu; jat@scripps.edu tpaull@mail.utexas.edu,jat@scripps.edu Accepted 2014-DEC-02 by MARTA EMBO J. (0261-4189) 2014 Only protein-protein interactions imex curation ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. (0261-4189) 2014 imex curation Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu,jat@scripps.edu 05-Jan-2015: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro crosslink cross-linking study crosslink weight by comassie molecular weight estimation by coomasie staining weight by comassie Deshpande R.A., Williams G.J., Limbo O., Williams R.S., Kuhnlein J., Lee J.H., Classen S., Guenther G., Russell P., Tainer J.A., Paull T.T. tpaull@mail.utexas.edu; jat@scripps.edu tpaull@mail.utexas.edu,jat@scripps.edu Accepted 2014-DEC-02 by MARTA EMBO J. (0261-4189) 2014 Only protein-protein interactions imex curation mre11_pyrfu DNA double-strand break repair protein Mre11 mre11 pfMre11 PF1166 protein protein pyrfu Pyrococcus furiosus MKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDLFHSSRPSPGTLKKAIALLQIPKEHSIPVFAIEGNHDRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAWFEANKEILKRLFRPTDNAILMLHQGVREVSEARGEDYFEIGLGDLPEGYLYYALGHIHKRYETSYSGSPVVYPGSLERWDFGDYEVRYEWDGIKFKERYGVNKGFYIVEDFKPRFVEIKVRPFIDVKIKGSEEEIRKAIKRLIPLIPKNAYVRLNIGWRKPFDLTEIKELLNVEYLKIDTWRIKERTDEESGKIGLPSDFFTEFELKIIDILGEKDFDDFDYIIKLITEGKVEEEGPLEEAVKKVSEEKGKTVRQKIESIPKKKRGTLDSWLGGAR DIP protein Q8U1N9 original sequence version: 56 639092C2F9C24DCD rad50_pyrfu DNA double-strand break repair Rad50 ATPase rad50 pfRad50 PF1167 protein protein pyrfu Pyrococcus furiosus MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLEETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDRKSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS DIP protein P58301 original sequence version: 78 3ADCBD250382A99E rad50-1 3 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction t1 rad50-1 1 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified range binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P58301:p.Leu802Trp mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain L W Wed May 02 15:18:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu802trp' Tue Jun 30 20:00:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu802Trp' direct interaction direct interaction sf1b f2a rad50-1 4 6 weight by staining molecular weight estimation by staining weight by staining weight by comassie molecular weight estimation by coomasie staining weight by comassie unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction F7B mre11-rad50-6 4 6 weight by staining molecular weight estimation by staining weight by staining weight by comassie molecular weight estimation by coomasie staining weight by comassie unspecified role unspecified role neutral component neutral component purified purified 5 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction F7C mre11-rad50-7 2 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction sf2