IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. Cancer Cell (1535-6108) 2014 imex curation Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro methyltransferase as methyltransferase assay methyltransferase as autoradiography autoradiography Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu Accepted 2014-FEB-03 by ORCHARD Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. Cancer Cell (1535-6108) 2014 imex curation Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu Accepted 2014-FEB-03 by ORCHARD Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. Cancer Cell (1535-6108) 2014 imex curation Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu Accepted 2014-FEB-03 by ORCHARD Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. Cancer Cell (1535-6108) 2014 imex curation Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. CARM1 KO cells reconstituted with CARM1 Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu Accepted 2014-FEB-03 by ORCHARD Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. Cancer Cell (1535-6108) 2014 imex curation Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu 18-Feb-2014: Contacted by IntAct-Help. Only protein-protein interactions human-skov_3 Homo sapiens ovarian adenocarcinoma cell line skov_3 Human ovarian adenocarcinoma cell line Derived from the ascitic fluid from a 64 year old caucasian female with an ovarian tumour. Forms moderately well-differentiated adenocarcinoma consistent with ovarian primary cells. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang L., Zhao Z., Meyer M.B., Saha S., Yu M., Guo A., Wisinski K.B., Huang W., Cai W., Pike J.W., Yuan M., Ahlquist P., Xu W. Cancer - Interactions investigated in the context of cancer Figure 2E not added as we decided it is not showing the IP of CARM1 by BAF155 - just that CARM1 is present.(positive control) - though this is not stated....So Expt 2 deleted. Results involving detection by ADMA have not been included as the anibody is not specific for a particular PRMT. wxu@oncology.wisc.edu Accepted 2014-FEB-03 by ORCHARD Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation carm1_human Histone-arginine methyltransferase CARM1 CARM1 PRMT4 Protein arginine N-methyltransferase 4 Coactivator-associated arginine methyltransferase 1 protein protein human Homo sapiens Human MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIPTNTMHYGS DIP protein Q86X55 original sequence version: 115 094AC60D4A70B263 ndrg1_human_gene Human NDRG1 gene gene gene human Homo sapiens Human smrd1_human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 SMARCD1 BAF60A SWI/SNF complex 60 kDa subunit 60 kDa BRG-1/Brm-associated factor subunit A BRG1-associated factor 60A protein protein human Homo sapiens Human MAARAGFQSVAPSGGAGASGGAGAAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLEDSALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT DIP protein Q96GM5 original sequence version: null DIP protein Q96GM5 original sequence version: 75 E683AA1E345DA400 co1a2_human_gene CO1A2_HUMAN_GENE gene gene human Homo sapiens Human g45a_human_gene GA45A_HUMAN_GENE gene gene human Homo sapiens Human ddx18_human_gene DDX18_HUMAN_GENE gene gene human Homo sapiens Human smrc1_human SWI/SNF complex subunit SMARCC1 SMARCC1 BAF155 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 SWI/SNF complex 155 kDa subunit BRG1-associated factor 155 protein protein human Homo sapiens Human MAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKPWKVHVKWILDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKKDSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAKGDQSRSVDLGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPVDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEKMEADPDGQQPEKAENKVENETDEGDKAQDGENEKNSEKEQDSEVSEDTKSEEKETEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQHGQNPQQAHQHSGGPGLAPLGAAGHPGMMPHQQPPPYPLMHHQMPPPHPPQPGQIPGPGSMMPGQHMPGRMIPTVAANIHPSGSGPTPPGMPPMPGNILGPRVPLTAPNGMYPPPPQQQPPPPPPADGVPPPPAPGPPASAAP DIP protein Q92922 original sequence version: 99 EDA6FF5B0472AEA9 smca4_human Transcription activator BRG1 SMARCA4 BRG1 SNF2B SNF2L4 ATP-dependent helicase SMARCA4 SNF2-beta BAF190A Mitotic growth and transcription activator Protein BRG-1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 Protein brahma homolog 1 BRG1-associated factor 190A protein protein human Homo sapiens Human MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED DIP protein P51532 original sequence version: 125 DIP protein P51532 original sequence version: 115 DIP protein P51532 original sequence version: 154 DIP protein P51532 original sequence version: 136 DIP protein P51532-1 original sequence version: 136 ABDA5EDBF10D7D28 acl6a_human Actin-like protein 6A 53 kDa BRG1-associated factor A Actin-related protein Baf53a ArpNbeta BAF53A ACTL6A BAF53 INO80K INO80 complex subunit K BRG1-associated factor 53A protein protein human Homo sapiens Human MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAERLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP ECD92D29BD1854E0 cadh1_human_gene Human CDH1gene:Epithelial cadherin gene gene human Homo sapiens Human cdca7_human_gene CDCA7_HUMAN_GENE nucleic acid nucleic acid human Homo sapiens Human snf5_human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 SMARCB1 INI1 SNF5L1 Integrase interactor 1 protein BAF47 SNF5 homolog BRG1-associated factor 47 protein protein human Homo sapiens Human MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW B7BCA26875BD943D smca2_human Probable global transcription activator SNF2L2 ATP-dependent helicase SMARCA2 SNF2-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 SMARCA2 BRM SNF2A SNF2L2 BAF190B Protein brahma homolog BRG1-associated factor 190B protein protein human Homo sapiens Human MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTMGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNRGKAKPVVSDFDSDEEQDEREQSEGSGTDDE DIP protein P51531 original sequence version: 66 DIP protein P51531 original sequence version: 126 CE69BBB287D35AB5 tff1_human_gene PS2/TFFI HUMAN GENE gene gene human Homo sapiens Human carm1-smarcc1 1 6 enzyme enzyme unspecified role unspecified role human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 12 enzyme target enzyme target substrate substrate unspecified role unspecified role n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range Q92922:p.Arg1064Lys mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate certain certain sequence position certain certain certain sequence position certain R K Wed May 02 19:13:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 18:50:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. methylation methylation reaction methylation 2D, 3D, Supp 2G Q86X55 increases activity of Q92922 Q92922 methylated residue smarcc1-carm1-1 4 6 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait physical association physical association 3E carm1-smarcc1-1 4 6 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey physical association physical association 3E carm1-smarcc1-2 3 12 unspecified role unspecified role prey prey n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range n_terminus t7 tag t7 tag MASMTGGQQMG epitope tag MASMTGGQQMG epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range c_terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range nuclear_localisation_signal tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 6 unspecified role unspecified role bait bait n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecoli Escherichia coli (strain K12) direct interaction direct interaction 3F smarcc1-cadh1 2 12 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey association association 5A Supp 5C Reduced binding was seen using the R1064lys BAF155 mutant, but this was not statistically significant. smarcc1-cadh1-1 2 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:26:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 19:26:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' 16 unspecified role unspecified role prey prey association association 5Aii smarcc1-cdca7 2 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 17:39:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 17:40:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' 9 unspecified role unspecified role prey prey association association 5Aiii Q92922 increases expression at RNA level of ENSG00000164692 smarcc1-co1a2 2 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 17:38:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 20:03:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' 10 unspecified role unspecified role prey prey association association 5Aiv Q92922 increases expression at RNA level of ENSG00000116717 smarcc1-g45a 2 11 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 15:30:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 20:13:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' association association 5Av smarcc1-ddx18 2 7 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 19:40:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 20:19:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' association association 5Avi smarcc1-co1a2-1 2 9 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 15:53:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 18:41:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' arg1064 nonome2arg asymmetric dimethyl-L-arginine (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine Dimethyl NoNoMe2Arg di-Methylation certain certain sequence position certain certain certain sequence position certain association association 5Bi/5D/5E CARM1 KO resulted in significant decreases of BAF155 association with the binding regions of COL1A2 and GADD45A. smarcc1-g45a-1 2 12 unspecified role unspecified role bait bait Q92922:p.Arg1064Lys mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain R K Wed May 02 18:01:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg1064lys' Tue Jun 30 15:40:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg1064Lys' arg1064 nonome2arg asymmetric dimethyl-L-arginine (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine Dimethyl NoNoMe2Arg di-Methylation certain certain sequence position certain certain certain sequence position certain 10 unspecified role unspecified role prey prey association association 5B/5F/5G CARM1 KO resulted in significant decreases of BAF155 association with the binding regions of COL1A2 and GADD45A. smarcc1-co1a2-2 2 17 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey association association 5E, Supp 5D smarcc1-g45a-2 2 17 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey association association 5G, Supp 5D smarcc1-smarca4-3 5 13 unspecified role unspecified role prey prey 8 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait association association Supp 4 smarcb1-g45a 2 15 unspecified role unspecified role prey prey 17 unspecified role unspecified role bait bait association association Supp 5C/D smarcc1-cadh1-2 2 15 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait association association Supp 5C/D smarca4-cadh1 2 18 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey association association Supp 5Ci smarca2-cadh1 2 15 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait association association Supp 5Cii smarcc1-cadh1-3 2 19 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait association association Supp 5C Reduced binding was seen using the R1064lys BAF155 mutant, but this was not statistically significant. smarca4-cadh1-1 2 19 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait association association Supp 5C smarcb1-g45a-1 2 17 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey association association Supp 5C actl6a-cadh1 2 19 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait association association Supp 5Cii smarca4-tff1 2 13 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey association association Supp 5D smarca4-g45a-1 2 13 unspecified role unspecified role bait bait 11 unspecified role unspecified role prey prey association association supp 5D smarcb1-cadh1 2 17 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey association association Supp 5D