MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS letters 2013 imex curation Lanlan Li, Jiayi Wang, Yue Zhang, Yan Zhang, Lifang Ma, Wenhao Weng, YongxiaQiao, Weifan Xiao, Hongmei Wang, Wenjun Yu, Qiuhui Pan, Yunyan He, Fenyong Sun, Li L., Wang J., Zhang Y., Zhang Y., Ma L., Weng W., Qiao Y., Xiao W., Wang H., Yu W., Pan Q., He Y., Sun F. sunfenyong@126.com 22-Nov-2013: Contacted by IntAct-Help. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Lanlan Li; Jiayi Wang; Yue Zhang; Yan Zhang; Lifang Ma; Wenhao Weng; Yongxia Qiao; Weifan Xiao; Hongmei Wang; Wenjun Yu; Qiuhui Pan; Yunyan He; Fenyong Sun sunfenyong@126.com Accepted 2013-OCT-30 by LUANA 22-Nov-2013: Contacted by IntAct-Help. 2013 Only protein-protein interactions imex curation MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS letters 2013 imex curation Lanlan Li, Jiayi Wang, Yue Zhang, Yan Zhang, Lifang Ma, Wenhao Weng, YongxiaQiao, Weifan Xiao, Hongmei Wang, Wenjun Yu, Qiuhui Pan, Yunyan He, Fenyong Sun, Li L., Wang J., Zhang Y., Zhang Y., Ma L., Weng W., Qiao Y., Xiao W., Wang H., Yu W., Pan Q., He Y., Sun F. sunfenyong@126.com 22-Nov-2013: Contacted by IntAct-Help. Only protein-protein interactions human Homo sapiens Human fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Lanlan Li; Jiayi Wang; Yue Zhang; Yan Zhang; Lifang Ma; Wenhao Weng; Yongxia Qiao; Weifan Xiao; Hongmei Wang; Wenjun Yu; Qiuhui Pan; Yunyan He; Fenyong Sun sunfenyong@126.com Accepted 2013-OCT-30 by LUANA 22-Nov-2013: Contacted by IntAct-Help. 2013 Only protein-protein interactions imex curation MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS letters 2013 imex curation Lanlan Li, Jiayi Wang, Yue Zhang, Yan Zhang, Lifang Ma, Wenhao Weng, YongxiaQiao, Weifan Xiao, Hongmei Wang, Wenjun Yu, Qiuhui Pan, Yunyan He, Fenyong Sun, Li L., Wang J., Zhang Y., Zhang Y., Ma L., Weng W., Qiao Y., Xiao W., Wang H., Yu W., Pan Q., He Y., Sun F. sunfenyong@126.com 22-Nov-2013: Contacted by IntAct-Help. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lanlan Li; Jiayi Wang; Yue Zhang; Yan Zhang; Lifang Ma; Wenhao Weng; Yongxia Qiao; Weifan Xiao; Hongmei Wang; Wenjun Yu; Qiuhui Pan; Yunyan He; Fenyong Sun sunfenyong@126.com Accepted 2013-OCT-30 by LUANA 22-Nov-2013: Contacted by IntAct-Help. 2013 Only protein-protein interactions imex curation fbw1a_human F-box/WD repeat-containing protein 1A BTRC BTRCP FBW1A FBXW1A F-box and WD repeats protein beta-TrCP E3RSIkappaB pIkappaBalpha-E3 receptor subunit Epididymis tissue protein Li 2a protein protein human Homo sapiens Human MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR DIP protein Q9Y297 original sequence version: 142 DIP protein Q9Y297 original sequence version: 153 DIP protein Q9Y297 original sequence version: 144 DIP protein Q9Y297 original sequence version: 145 DIP protein Q9Y297 original sequence version: 106 DIP protein Q9Y297 original sequence version: 82 DIP protein Q9Y297 original sequence version: 111 DIP protein Q9Y297 original sequence version: 125 4C67F3B7E400FD37 yap1_human Transcriptional coactivator YAP1 YAP1 YAP65 Protein yorkie homolog Yes-associated protein YAP65 homolog protein protein human Homo sapiens Human MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL DIP protein P46937 original sequence version: 143 DIP protein P46937 original sequence version: 98 DIP protein P46937-1 original sequence version: 110 DIP protein P46937 original sequence version: 149 DIP protein P46937 original sequence version: 153 DIP protein P46937 original sequence version: 157 DIP protein P46937 original sequence version: 160 DIP protein P46937 original sequence version: 122 DIP protein P46937 original sequence version: 124 6145F7049ED338AE mp2k1_human Dual specificity mitogen-activated protein kinase kinase 1 ERK activator kinase 1 MAPK/ERK kinase 1 MAP2K1 MEK1 PRKMK1 protein protein human Homo sapiens Human MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV DIP protein Q02750 original sequence version: 96 DIP protein Q02750 original sequence version: 93 DIP protein Q02750-1 original sequence version: 151 DIP protein Q02750 original sequence version: 151 DIP protein Q02750-1 original sequence version: 166 0344118FFC842D51 map2k1-yap1 2 YAP 5 immunostaining immunostaining immunostaining immunostaining unspecified role unspecified role unspecified role unspecified role physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell MEK1 6 immunostaining immunostaining immunostaining immunostaining unspecified role unspecified role unspecified role unspecified role physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell colocalization colocalization f4b Colocalization was confirmed in both HepG2 and Bel-7402 cells map2k1-yap1-1 1 YAP 5 western blot western blot Immuno blot Immuno blot western blot western blot Immuno blot Immuno blot unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level MEK1 6 western blot western blot Immuno blot Immuno blot western blot western blot Immuno blot Immuno blot unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association f4c Interaction was confirmed in both HepG2 and Bel-7402 cells yap1-map2k1 3 MEK1 6 anti tag western anti tag western blot anti tag western anti tag western anti tag western blot anti tag western unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined YAP 5 anti tag western anti tag western blot anti tag western anti tag western anti tag western blot anti tag western unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell flag tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association f4d Interaction was confirmed in both Hek293T cells. btrc-map2k1 1 MEK1 6 western blot western blot Immuno blot Immuno blot western blot western blot Immuno blot Immuno blot unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level BTRC 4 western blot western blot Immuno blot Immuno blot western blot western blot Immuno blot Immuno blot unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association f5e Interaction was confirmed in both HepG2 and Bel-7402 cells btrc-map2k1-1 2 MEK1 6 immunostaining immunostaining immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell BTRC 4 immunostaining immunostaining immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell colocalization colocalization f5g Interaction was confirmed in both HepG2 and Bel-7402 cells map2k1-btrc 3 MEK1 6 anti tag western anti tag western blot anti tag western anti tag western anti tag western blot anti tag western unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell ha tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 4 anti tag western anti tag western blot anti tag western anti tag western anti tag western blot anti tag western unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell flag tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association f5f Interaction was confirmed in both Hek293T cells.