MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Phosphorylation of Noxo1 at threonine-341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1 Phosphorylation of Noxo1 at threonine-341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1 FEBS J. (1742-464X) 2013 imex curation Yamamoto A., Takeya R., Matsumoto M., Nakayama K.I., Sumimoto H. hsumi@med.kyushu-u.ac.jp 30-Sept-2013: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Yamamoto A., Takeya R., Matsumoto M., Nakayama K.I., Sumimoto H. hsumi@med.kyushu-u.ac.jp Accepted 2013-SEP-09 by MARTA 30-Sept-2013: Contacted by IntAct-Help. FEBS J. (1742-464X) 2013 Only protein-protein interactions imex curation noxo1_human NADPH oxidase organizer 1 NOXO1 P41NOX SH3PXD5 Nox-organizing protein 1 Nox organizer 1 NADPH oxidase regulatory protein SH3 and PX domain-containing protein 5 protein protein human Homo sapiens Human MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ mint homomint 2E9525A8BADDB360 q8nfa2-3 NADPH oxidase organizer 1 Nox-organizing protein 1 SH3 and PX domain-containing protein 5 NADPH oxidase regulatory protein Nox organizer 1 NOXO1 P41NOX SH3PXD5 NOXO1beta protein protein human Homo sapiens Human MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ 39E13C3FF491797E noxa1_human NADPH oxidase activator 1 NCF2-like protein Antigen NY-CO-31 P67phox-like factor p51-nox NOXA1 P51NOX protein protein human Homo sapiens Human MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQGDQP 64DFBF64C59722AD cy24a_human Cytochrome b-245 light chain p22 phagocyte B-cytochrome Neutrophil cytochrome b 22 kDa polypeptide p22-phox Cytochrome b(558) alpha chain Cytochrome b558 subunit alpha Superoxide-generating NADPH oxidase light chain subunit CYBA protein protein human Homo sapiens Human MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVFVCLLEYPRGKRKKGSTMERWGQKYMTAVVKLFGPFTRNYYVRAVLHLLLSVPAGFLLATILGTACLAIASGIYLLAAVRGEQWTPIEPKPRERPQIGGTIKQPPSNPPPRPPAEARKKPSEEEAAVAAGGPPGGPQVNPIPVTDEVV DIP protein P13498 original sequence version: 99 428427AD19398240 cyba-noxo1-2 1 p22phox 5 unspecified role unspecified role prey prey mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P13498:p.Pro156Gln mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P Q Wed May 02 16:44:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro156gln' Tue Jun 30 16:11:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro156Gln' ecoli Escherichia coli (strain K12) Noxo1 3 acceptor acceptor bait bait gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q8NFA2-3:p.Ser195Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S A Wed May 02 16:38:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu195ala' Tue Jun 30 17:07:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser195Ala' binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction f4d noxo1-cyba-1 1 Noxo1 3 acceptor acceptor bait bait Q8NFA2-3:p.Ser195Glu mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S E Wed May 02 17:15:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu195glu' Tue Jun 30 18:28:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser195Glu' binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) p22phox 5 unspecified role unspecified role prey prey P13498:p.Pro156Gln mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P Q Wed May 02 19:28:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro156gln' Tue Jun 30 18:47:20 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro156Gln' mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) direct interaction direct interaction f4d noxo1-cyba-2 1 Noxo1 3 acceptor acceptor bait bait gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q8NFA2-3:p.Ser195Asp mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain S D Wed May 02 19:16:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu195asp' Tue Jun 30 17:17:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser195Asp' binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) p22phox 5 unspecified role unspecified role prey prey mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P13498:p.Pro156Gln mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P Q Wed May 02 15:13:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro156gln' Tue Jun 30 17:53:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro156Gln' ecoli Escherichia coli (strain K12) direct interaction direct interaction f4d noxo1-cyba-3 1 Noxo1 3 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie acceptor acceptor prey prey purified purified mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q8NFA2-3:p.Thr343Ala mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T A Wed May 02 20:23:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg343ala' Tue Jun 30 20:14:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr343Ala' ecoli Escherichia coli (strain K12) Noxa1 4 unspecified role unspecified role bait bait gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction f6a noxa1-noxo1-1 1 Noxa1 4 unspecified role unspecified role bait bait binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q86UR1:p.Trp436Arg mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain W R Wed May 02 15:58:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp436arg' Tue Jun 30 18:32:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp436Arg' ecoli Escherichia coli (strain K12) Noxo1 3 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie acceptor acceptor prey prey purified purified mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q8NFA2-3:p.Thr341Ala mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T A Wed May 02 17:04:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln341ala' Tue Jun 30 18:55:14 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr341Ala' ecoli Escherichia coli (strain K12) direct interaction direct interaction f6b noxa1-noxo1-2 1 Noxa1 4 unspecified role unspecified role bait bait gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q86UR1:p.Trp436Arg mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain W R Wed May 02 19:43:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp436arg' Tue Jun 30 16:12:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp436Arg' ecoli Escherichia coli (strain K12) Noxo1 3 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie acceptor acceptor prey prey purified purified mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction f6c noxa1-noxo1-3 1 Noxo1 3 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie acceptor acceptor prey prey purified purified binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q8NFA2-3:p.Thr341Asp mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T D Wed May 02 17:03:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln341asp' Tue Jun 30 17:10:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr341Asp' ecoli Escherichia coli (strain K12) Noxa1 4 unspecified role unspecified role bait bait gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction f6e noxa1-noxo1-4 1 Noxo1 3 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie acceptor acceptor prey prey purified purified Q8NFA2-3:p.Thr341Glu mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain T E Wed May 02 14:44:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln341glu' Tue Jun 30 17:06:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr341Glu' mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) Noxa1 4 unspecified role unspecified role bait bait binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) direct interaction direct interaction f6e noxa1-noxo1-5 1 Noxo1 2 weight by comassie molecular weight estimation by coomasie staining weight by comassie weight by comassie molecular weight estimation by coomasie staining weight by comassie biological role biological role prey prey purified purified binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain mbp-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) Noxo1 3 unspecified role unspecified role bait bait gst-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain Q8NFA2-3:p.Trp197Arg mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain W R Wed Jun 13 17:38:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg197arg' Tue Jun 30 16:01:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp197Arg' ecoli Escherichia coli (strain K12) direct interaction direct interaction f6d