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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="17135203" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0471" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-80017" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579228" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="17135203" refType="primary-reference" refTypeAc="MI:0358"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="23601781" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="mint" dbAc="MI:0471" id="fj-13-0088" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="mint" dbAc="MI:0471" id="MINT-8427104" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="mint" dbAc="MI:0471" id="MINT-8427106" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8517044" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.</attribute>
            <attribute name="journal" nameAc="MI:0885">FEBS J. (1742-464X)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2013</attribute>
            <attribute name="author-list" nameAc="MI:0636">Duddempudi PK., Nakashe P., Blanton MP., Jansen M.</attribute>
            <attribute name="remark-internal">suggested by lperfetto</attribute>
            <attribute name="mimix curation" nameAc="MI:0960">mimix curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8427106" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="fj-13-0088" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="23601781" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="fj-13-0088" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>crosslink</shortLabel>
            <fullName>cross-linking study</fullName>
            <alias type="synonym" typeAc="MI:1041">crosslink</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0030" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1049" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>experimental particp</shortLabel>
            <fullName>experimental participant identification</fullName>
            <alias type="synonym" typeAc="MI:1041">experimental particp</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0661" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933978" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Duddempudi PK., Nakashe P., Blanton MP., Jansen M.</attribute>
          <attribute name="remark-internal">suggested by lperfetto</attribute>
          <attribute name="journal" nameAc="MI:0885">FEBS J. (1742-464X)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2013</attribute>
          <attribute name="mimix curation" nameAc="MI:0960">mimix curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>pcft_human</shortLabel>
          <fullName>Proton-coupled folate transporter</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">HCP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PCFT</alias>
          <alias type="gene name synonym" typeAc="MI:0302">G21</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Heme carrier protein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PCFT/HCP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Solute carrier family 46 member 1</alias>
          <alias type="gene name" typeAc="MI:0301">SLC46A1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q96NT5" version="SP_79" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q1HE20" version="SP_79" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q86T92" version="SP_79" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8TEG3" version="SP_79" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96FL0" version="SP_79" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000480703" version="SP_161" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-4319513" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229295.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_542400.2"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000076351" version="SP_161" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000612814" version="SP_161" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005542" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006879" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008517" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015078" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015232" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015350" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015884" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016323" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031526" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042168" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046655" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051958" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098829" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902600" version="SP_161"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904447" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005829" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011701" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020846" version="SP_161"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036259" version="SP_161"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q96NT5" version="SP_161"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-196757" version="SP_161"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-917937" version="SP_161"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9707616" version="SP_161"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP</sequence>
        <attributeList>
          <attribute name="crc64">119F89E9E4ACA5F4</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3">
        <names>
          <shortLabel>slc46a1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8427109" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8517061" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">PCFT</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8427111" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>western blot</shortLabel>
                  <fullName>western blot</fullName>
                  <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
                  <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>experimental particp</shortLabel>
                  <fullName>experimental participant identification</fullName>
                  <alias type="synonym" typeAc="MI:1041">experimental particp</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0661" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-933978" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>purified</shortLabel>
                  <fullName>purified</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <stoichiometry value="2"/>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 2.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">f4 f5</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>