UniProt UniProt http://www.uniprot.org Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. PLoS ONE 2013 mimix curation Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk 8-May-2012: Contacted by IntAct-Help. chlae-vero Chlorocebus (Cercopithecus) aethiops kidney cells Grivet vero Chlorocebus (Cercopithecus) aethiops kidney cells similar to cos-7 cells but these are not trasnformed anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk Accepted 2013-APR-25 by ORCHARD 8-May-2012: Contacted by IntAct-Help. PLoS ONE 2013 mimix curation Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. PLoS ONE 2013 mimix curation Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk 8-May-2012: Contacted by IntAct-Help. chlae-vero Chlorocebus (Cercopithecus) aethiops kidney cells Grivet vero Chlorocebus (Cercopithecus) aethiops kidney cells similar to cos-7 cells but these are not trasnformed anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk Accepted 2013-APR-25 by ORCHARD 8-May-2012: Contacted by IntAct-Help. PLoS ONE 2013 mimix curation Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. PLoS ONE 2013 mimix curation Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk 8-May-2012: Contacted by IntAct-Help. human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk Accepted 2013-APR-25 by ORCHARD 8-May-2012: Contacted by IntAct-Help. PLoS ONE 2013 mimix curation b8pzp6_9mono P/V/C P protein protein measd Measles virus (strain Dublin) (MeV) MAEEQARHVKNGLECIRALKAEPIGSLAIEEAMAAWSEISDNPGQERATCREEKAGSSGLSKPCLSAIGSTEGGAPRIRGQGPGESDDDAETLGIPPRNLQASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSGTPIKKGHRREISLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE 8B545A8C6ACDAD27 q6tv27_9mono protein protein canine distemper virus Canine distemper virus MAEEQAYHVSKGLECLKALRENPPDLEEIQEVSSIRDQTRNPGQENGTASMQEEEVSQDLDESHEPAKGSNYVGHVLQNNPGSGKGNTALVEAEQPAKDVIQPGPGIRCYHVYDHSGEEVKGTEDADSLVVPAGAVSNRGFERGEGSLDDSTEDSGEDYSEGNASSNWGYSFGLKPDRAADVSMLMEEELSALLKTSRNVGIQKRDGKTLQFPHNPEGKTGDPECGSIKKGHRREVSLTWNGDSCWIDKWCNPICTQVNWGIIRAKCVCGECPPTCSECKDDPEMQTRVWYATPSQDLK 6D8F817FAC380D0B q4r4g2_chlae Signal transducer and activator of transcription STAT1 alpha protein protein chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYNCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLNPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPYFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKFLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNAV D351514CFC8692C3 tyk2_human Non-receptor tyrosine-protein kinase TYK2 TYK2 protein protein human Homo sapiens Human MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC DIP protein P29597 original sequence version: 155 F76C25D6A919EDBC proteinv_cdvo Non-structural protein V protein protein cdvo Canine distemper virus (strain Onderstepoort) (CDV) MAEEQAYHVSKGLECLKALRENPPDIEEIQEVSSLRDQTCNPGQENGTTGMQEEEDSQNLDESHEPTKGSNYVGHVPQNNPGCGERNTALVEAERPPREDIQPGPGIRCDHVYDHSGEEVKGIEDADSLVVPAGTVGNRGFERGEGSLDDSTEDSGEDYSEGNASSNWGYSFGLKPDRAADVSMLMEEELSALLRTSRNVGIQKRDGKTLQFPHNPEGKTRDPECGSIKKGHRREVSLTWNGDSCWIDKWCNPICTQVNWGIIRAKCFCGECPPTCNECKDDPEMQTRVWHATPSQDLK personal communication, submitted by MD Baron, michael.baron@pirbright.ac.uk v_rindsa Non-structural protein V protein protein rind-sa Rinderpest virus (strain Sa) (RDV) MAEEQAYHVNKGLECIKALRARPLDSQVVEEALAAWVETSEGQTLDRMSPDEAEADYQDIGKPCFSATGPGKSSKSRSHDQEPGESNICDGELGALMDDTPMHNTEIQRYHVYDHSGEKVEGVEDADSILVQSGADDGVEFWGGDEESENSDVDPGELDPEGNAPADWRSSPIPPTTRASDVETVEGDEIQKLLEDQSRARKMTKAGKTLVVPPIPSHERSIASEKPIKKGHRREISLIWNDDRVFIDRWCNPTCSKVTVGTVRAKCICGECPRVCEQCFADPGIENRIWYHSLADVPE personal communication and submission, Dr MD Baron michael.baron@pirbright.ac.uk jak1_human Tyrosine-protein kinase JAK1 JAK1 JAK1A JAK1B Janus kinase 1 protein protein human Homo sapiens Human MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK DIP protein P23458 original sequence version: 120 A2C4BE27851ACABB proteinv_measd Non-structural protein V protein protein measd Measles virus (strain Dublin) (MeV) MAEEQARHVKNGLECIRALKAEPIDSLAVEEAMAAWSEISDNPGQDRATCKEGKAGSSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDAETLGIPSRNLQASSTGLQCYHVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDDESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGREIHELLRLQSRGNNFPKIGKTLNVPPPPNPDRASTSETPIKKGHRREISLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE q4r4g0_chlae Signal transducer and activator of transcription STAT2 protein protein chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAVLGNDDSKATMLFFHFLDQLNYECGRCSQDPDSLLLQHNLRKFCRDIQAFSQGPTQLAEMIFNLLLEEKRILIQAQRAQPEQGEPALVTPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFSFRYKIQAKGKTPSLDSHQTKEQQILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLEKWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLIKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTISGTFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKLEPELESLELELGLAPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVMEPTLCMVSQTVPEPDRGPVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEAYVSRPSHFYTDGPLMPSDF E4D3348F15E0FABC q5zer6_pprv V protein protein Peste-des-petits-ruminants virus Peste-des-petits-ruminants virus MAEEQAYHVNKGLECIKSLKASPPDLSTIRDTIESWREGLSPSGRATPNPDTSEGDHQSINQSCSPAIGPNKVYLSPGDNLGFREITGNDCEAGLGGVQGKRSNSQVQRYYVYSHGGEEIEGLEDADSLVVQADPPVANVFNGGEDGSDDSDVDSGPDDPSRDTLYDRGSVAGNDVARSTDVEKLEGADIQEVLNSQKGKGGRFQGGKTLRVPEIPDVKHSRPSAQSIKKGTDGNSVSSGTVTECLSISGATQAVPESRWESSEQNASVGSVLKSARSAETIQGLTQESGTIASLTQP 710D724AC9202225 v_rindr Non-structural protein V P/V protein protein rindr Rinderpest virus (strain RBOK) MAEEQAYHVNKGLECIKALRARPLDPLVVEEALAAWVETSEGQTLDRMSSDEAEADHQDISKPCFPAAGPGKSSMSRCHDQGLRGSNSCDEELGAFIGDSSMHSTEVQHYHVYDHSGEKVEGVEDADSILVQSGADDGVEVWGGDEESENSDVDSGEPDPEGSAPADWGSSPISPATRASDVETVEGDEIQKLLEDQSRIRKMTKAGKTLVVPPIPSQERPTASEKPIKKGHRREIDLIWNDGRVFIDRWCNPTCSKVTVGTVRAKCICGECPRVCEQCITDSGIENRIWYHNLADIPE 0B58C872C5B9705E v-stat1_alpha-1 1 9 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey association association 5 p_v-stat1_alpha 1 6 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait association association 5 protein-stat1_alpha 1 11 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey association association 5 Weak association p-p_v 1 4 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey association association 5 Weak association. v-stat1_alpha-2 1 13 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey association association 5 q6tv27-stat1_alpha 1 6 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey 5 unspecified role unspecified role bait bait association association 5 Weak association protein_v-stat1_alph 1 8 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey association association 5 Weak association. tyk2-v 2 9 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait physical association physical association 9A v-tyk2 2 9 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9A v-jak1-1 2 9 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 9A jak1-jak2 2 9 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait physical association physical association 9A v-tyk2-1 3 9 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9B v-jak1 3 9 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 9C p_v-jak1 3 10 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait physical association physical association 9C p_v-tyk2-1 3 7 unspecified role unspecified role prey prey 14 unspecified role unspecified role bait bait physical association physical association 9B tyk2-protein 3 11 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9B protein-jak1 3 11 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 9C protein_v-tyk2 3 8 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9B protein_v-jak1 3 8 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 9C p-p_v-1 3 4 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9B p-p_v-2 3 10 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait physical association physical association 9C v-tyk2-2 3 13 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 9B v-jak1-2 3 10 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait physical association physical association 9C q6tv27-jak1 3 5 unspecified role unspecified role bait bait 10 unspecified role unspecified role prey prey physical association physical association 9C q6tv27-tyk2 3 7 unspecified role unspecified role prey prey 5 unspecified role unspecified role bait bait physical association physical association 9B