IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell (0092-8674) 2012 imex curation Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Peptides and proteins were identified with a false discovery rate of <1% employing the following search criteria: MS tolerance for “first search” 20 ppm, initial MS and MS/MS mass tolerances of 6 ppm and 0.4 Da, respectively; at least one unique peptide (≥6 amino acids); trypsin as enzyme with a maximum of two missed cleavages; methionine oxidation and dimethylation at lysine or arginine as variable modification; 13C615N2-lysine and 13C615N4-arginine as heavy labeled amino acids. If peptides were assigned to different proteins or multiple isoforms, the respective proteins were reported as a single protein group. For SILAC (stable isotope labeling of amino acids in cell culture)-based quantification of proteins or protein groups, “razor” peptides and a minimum ratio count of two were considered. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Accepted 2013-MAY-17 by MGT 17-Jun-2013: Contacted by IntAct-Help. Cell (0092-8674) 2012 Only protein-protein interactions imex curation MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell (0092-8674) 2012 imex curation Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. bn-page blue native page bn-page sequence tag sequence tag identification sequence tag Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. The SILAC normalized light-over-heavy (L/H; replicates 1 and 3) or heavy-over-light (H/L; replicates 2 and 4) ratios were calculated. Ratios were log-transformed, and the mean log10 ratio across all experiments was calculated for each protein. A one-sided t test was performed to determine p values for all proteins quantified in at least two experiments. Proteins considered to specifically enrich with the bait protein MITRAC12 were required to be identified with at least two peptides as well as quantified with a mean ratio of ≥15 and a p value of < 0.01. SILAC data obtained from affinity-purified MITRAC12 complexes data were subjected to hierarchical clustering performed in the R environment using Euclidian distances and complete linkage. Only proteins reliably identified in both repeats with at least two peptides were considered and common contaminants like keratins were excluded. In addition, proteins were required to be enriched in both repeats with a minimum SILAC ratio of three in at least one replicate. I've annotated the clusters rather than the slices, as being vaguely more biologically meaningful so I've deliberately ignored 6C as this is representative of 1 slice. MITRAC12-containing complexes from isolated by anti-tag coip from differentially SILAC labeled mitochondria for subsequent separation by BN-PAGE. BN-PAGE gel was sliced into 20 strips, the proteins identified were then clustered as described in 'author-confidence'. Cluster 5 identified proteins that peaked in fractions 1 or 2, indicating that these did not run into the gel and therefore could represent aggregates and have not been reported. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Accepted 2013-MAY-17 by MGT 17-Jun-2013: Contacted by IntAct-Help. Cell (0092-8674) 2012 Only protein-protein interactions imex curation MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell (0092-8674) 2012 imex curation Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Accepted 2013-MAY-17 by MGT 17-Jun-2013: Contacted by IntAct-Help. Cell (0092-8674) 2012 Only protein-protein interactions imex curation MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell (0092-8674) 2012 imex curation Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. bn-page blue native page bn-page western blot western blot Immuno blot Immuno blot Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Accepted 2013-MAY-17 by MGT 17-Jun-2013: Contacted by IntAct-Help. Cell (0092-8674) 2012 Only protein-protein interactions imex curation MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell (0092-8674) 2012 imex curation Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Accepted 2013-MAY-17 by MGT 17-Jun-2013: Contacted by IntAct-Help. Cell (0092-8674) 2012 Only protein-protein interactions imex curation atp5l_human ATP synthase subunit g, mitochondrial ATP5MG ATP synthase membrane subunit g ATP5L protein protein human Homo sapiens Human MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPRAIQSLKKIVNSAQTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYDV 03D484BCF836E6C2 cx7a2_human Cytochrome c oxidase subunit 7A2, mitochondrial COX7AL Cytochrome c oxidase subunit VIIa-liver/heart COX7A2 protein protein human Homo sapiens Human MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE 490F45059CAF971F b4drs6_human Sidoreflexin protein protein human Homo sapiens Human MESKMGELPLDINIQEPRWDQSTFLGRARHFFTVTDPRNLLLSGAQLEASRNIVQNYRAGVVTPGITEDQLWRAKYVYDSAFHPDTGEKVVLIGRMSAQGSKDEGHCRRGRSECLCSLRKTPTVVFWQWVNQSFNAIVNYSNRSGDTPITVRQLGTAYVSATTGAVATALGLKSLTKHLPPLVGRFVPFAAVAAANCINIPLMRQRELQVGIPVADEAGQRLGYSVTAAKQGIFQVVISRICMAIPAMAIPPLIMDTLEKKDFLKRRPWLGAPLQVGLVGFCLVFATPLCCALFPQKSSIHISNLEPELRAQIHEQNPSVEVVYYNKGL E4027A3618742E5E coxm1_human COX assembly mitochondrial protein homolog CMC1 C3orf68 protein protein human Homo sapiens Human MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQDFTKCCKNSGVLMVVKCRKENSALKECLTAYYNDPAFYEECKMEYLKEREEFRKTGIPTKKRLQKLPTSM CBC29CCCB76BA721 cmc1_human Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 ARALAR1 Mitochondrial aspartate glutamate carrier 1 Solute carrier family 25 member 12 protein protein human Homo sapiens Human MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ D00A7D3D4244539F rm46_human 39S ribosomal protein L46, mitochondrial Mitochondrial large ribosomal subunit protein mL46 MRPL46 C15orf4 LIECG2 P2ECSL protein protein human Homo sapiens Human MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSPWRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKKADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLLVREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFPQAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFVSDL EDA966D758715378 sim20_human Small integral membrane protein 20 SMIM20 C4orf52 MITRAC7 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa protein protein human Homo sapiens Human MSRNLRTALIFGGFISLIGAAFYPIYFRPLMRLEEYKKEQAINRAGIVQEDVQPPGLKVWSDPFGRK FCBA42B976E900AA mavs_human Mitochondrial antiviral-signaling protein Interferon beta promoter stimulator protein 1 Virus-induced-signaling adapter CARD adapter inducing interferon beta Putative NF-kappa-B-activating protein 031N MAVS IPS1 KIAA1271 VISA protein protein human Homo sapiens Human MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH 0E23E3E115941EE8 cox15_human Cytochrome c oxidase assembly protein COX15 homolog COX15 protein protein human Homo sapiens Human MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSLPSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK 98E9FD9D1D28EFC0 surf1_human Surfeit locus protein 1 SURF1 SURF-1 protein protein human Homo sapiens Human MAAVAALQLGLRAAGLGRAPASAAWRSVLRVSPRPGVAWRPSRCGSSAAEASATKAEDDSFLQWVLLLIPVTAFGLGTWQVQRRKWKLNLIAELESRVLAEPVPLPADPMELKNLEYRPVKVRGCFDHSKELYMMPRTMVDPVREAREGGLISSSTQSGAYVVTPFHCTDLGVTILVNRGFVPRKKVNPETRQKGQIEGEVDLIGMVRLTETRQPFVPENNPERNHWHYRDLEAMARITGAEPIFIDANFQSTVPGGPIGGQTRVTLRNEHLQYIVTWYGLSAATSYLWFKKFLRGTPGV EC890EA48A0EDE7A cox5a_human Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase polypeptide Va COX5A protein protein human Homo sapiens Human MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV 104DAF468BD302FC oma1_human Metalloendopeptidase OMA1, mitochondrial OMA1 MPRP1 Metalloprotease-related protein 1 Overlapping with the m-AAA protease 1 homolog protein protein human Homo sapiens Human MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS F8F9B37489B0EFF1 fxrd1_human FAD-dependent oxidoreductase domain-containing protein 1 FP634 FOXRED1 protein protein human Homo sapiens Human MIRRVLPHGMGRGLLTRRPGTRRGGFSLDWDGKVSEIKKKIKSILPGRSCDLLQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSVGGICQQFSLPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAMESNVKVQRQEGAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAAGAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLETPLVADTSGAYFRREGLGSNYLGGRSPTEQEEPDPANLEVDHDFFQDKVWPHLALRVPAFETLKVQSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQQAPGIGRAVAEMVLKGRFQTIDLSPFLFTRFYLGEKIQENNII 34A18ABED84BE676 adt2_human ADP/ATP translocase 2 SLC25A5 ANT2 Adenine nucleotide translocator 2 ADP,ATP carrier protein 2 Solute carrier family 25 member 5 ADP,ATP carrier protein, fibroblast isoform AAC2 protein protein human Homo sapiens Human MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT DIP protein P05141 original sequence version: 132 DC53D083E7217AFE acad9_human Complex I assembly factor ACAD9, mitochondrial ACAD9 Acyl-CoA dehydrogenase family member 9 protein protein human Homo sapiens Human MSGCGLFLRTTAAARACRGLVVSTANRRLLRTSPPVRAFAKELFLGKIKKKEVFPFPEVSQDELNEINQFLGPVEKFFTEEVDSRKIDQEGKIPDETLEKLKSLGLFGLQVPEEYGGLGFSNTMYSRLGEIISMDGSITVTLAAHQAIGLKGIILAGTEEQKAKYLPKLASGEHIAAFCLTEPASGSDAASIRSRATLSEDKKHYILNGSKVWITNGGLANIFTVFAKTEVVDSDGSVKDKITAFIVERDFGGVTNGKPEDKLGIRGSNTCEVHFENTKIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSEFGLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQILGGLGYTRDYPYERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQAKVSTVMDTVGRRLRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLRFGKTIMEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLANTFCVEAYLQNLFSLSQLDKYAPENLDEQIKKVSQQILEKRAYICAHPLDRTC DIP protein Q9H845 original sequence version: 90 064BCE0378877F54 tim50_human Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 TIM50 PRO1512 protein protein human Homo sapiens Human MAASAAVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGPSYAKKVALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLGSLTSRLWPRSKQP DIP protein Q3ZCQ8 original sequence version: 102 524EB9989BBF6988 vdac3_human Voltage-dependent anion-selective channel protein 3 VDAC3 Outer mitochondrial membrane protein porin 3 protein protein human Homo sapiens Human MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA E03CBCEDA72A9783 cmc2_human Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 ARALAR2 Mitochondrial aspartate glutamate carrier 2 Solute carrier family 25 member 13 Citrin protein protein human Homo sapiens Human MAAAKVALTKRADPAELRTIFLKYASIEKNGEFFMSPNDFVTRYLNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVKQVFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNARTGRVTAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTTSHQVSFSYFNGFNSLLNNMELIRKIYSTLAGTRKDVEVTKEEFVLAAQKFGQVTPMEVDILFQLADLYEPRGRMTLADIERIAPLEEGTLPFNLAEAQRQKASGDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYIDFGGVKPMGSEPVPKSRINLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSVSTSKAIGGGP AD07EDBC6C68989B ndua4_human Cytochrome c oxidase subunit NDUFA4 NADH-ubiquinone oxidoreductase MLRQ subunit Complex I-MLRQ NDUFA4 protein protein human Homo sapiens Human MLRQIIGQAKKHPSLIPLFVFIGTGATGATLYLLRLALFNPDVCWDRNNPEPWNKLGPNDQYKFYSVNVDYSKLKKERPDF 2FA1D1115EDE24C7 m2om_human Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 SLC20A4 Solute carrier family 25 member 11 protein protein human Homo sapiens Human MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG 9D61F817089FF5AA atp6_human ATP synthase subunit a MT-ATP6 ATP6 ATPASE6 MTATP6 F-ATPase protein 6 protein protein human Homo sapiens Human MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT 7DB0F0BE86F55207 taco1_human Translational activator of cytochrome c oxidase 1 PRO0477 TACO1 CCDC44 Translational activator of mitochondrially-encoded cytochrome c oxidase I Coiled-coil domain-containing protein 44 protein protein human Homo sapiens Human MSAWAAASLSRAAARCLLARGPGVRAAPPRDPRPSHPEPRGCGAAPGRTLHFTAAVPAGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKSTIETALKMEKSKDTYLLYEGRGPGGSSLLIEALSNSSHKCQADIRHILNKNGGVMAVGARHSFDKKGVIVVEVEDREKKAVNLERALEMAIEAGAEDVKETEDEEERNVFKFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDNIE 079C4716F32EE6FF tm177_human Transmembrane protein 177 TMEM177 protein protein human Homo sapiens Human MAGPLWRTAAFVQRHRTGLLVGSCAGLFGVPISYHLFPDPVVQWLYQYWPQGQPAPLPPQLQSLFQEVLQDIGVPSGHCYKPFTTFTFQPVSAGFPRLPAGAVVGIPASFLGDLVINTNHPVVIHGHTVDWRSPAGARLRASLTLSREAQKFALAREVVYLESSTTAVHALLAPACLAGTWALGVGAKYTLGLHAGPMNLRAAFSLVAAVAGFVAYAFSQDSLTHAVESWLDRRTASLSAAYACGGVEFYEKLLSGNLALRSLLGKDGEKLYTPSGNIVPRHLFRIKHLPYTTRRDSVLQMWRGMLNPGRS FC9697323D148426 q305v2_human NADH-ubiquinone oxidoreductase chain 2 ND2 protein protein human Homo sapiens Human MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTFSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPSPIPPHTHRPYHATPTYLPFYTNNLMEI BE6CFB479F4F72BB vdac1_human Voltage-dependent anion-selective channel protein 1 VDAC1 VDAC Outer mitochondrial membrane protein porin 1 Plasmalemmal porin Porin 31HL Porin 31HM protein protein human Homo sapiens Human MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA DIP protein P21796 original sequence version: 103 DIP protein P21796 original sequence version: 123 DIP protein P21796 original sequence version: 125 89BA3378B04020D5 atpd_human ATP synthase subunit delta, mitochondrial ATP5F1D ATP synthase F1 subunit delta ATP5D F-ATPase delta subunit protein protein human Homo sapiens Human MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEANEALVKALE B7F0D1D01ADFDFE7 cox2_human Cytochrome c oxidase subunit 2 MT-CO2 COII COXII MTCO2 Cytochrome c oxidase polypeptide II COX2 protein protein human Homo sapiens Human MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL DIP protein P00403 original sequence version: null 402A3145241DDEE6 pnkd_human Probable hydrolase PNKD Paroxysmal nonkinesiogenic dyskinesia protein Myofibrillogenesis regulator 1 Trans-activated by hepatitis C virus core protein 2 PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778 protein protein human Homo sapiens Human MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK A4D631D3A4319A2C rm40_human 39S ribosomal protein L40, mitochondrial Nuclear localization signal-containing protein deleted in velocardiofacial syndrome Up-regulated in metastasis MRPL40 NLVCF URIM Mitochondrial large ribosomal subunit protein mL40 protein protein human Homo sapiens Human MTASVLRSISLALRPTSGLLGTWQTQLRETHQRASLLSFWELIPMRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR AE6262A9A94B05FD cox41_human Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 COX4 Cytochrome c oxidase subunit IV isoform 1 Cytochrome c oxidase polypeptide IV protein protein human Homo sapiens Human MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK F6382FFDCF3BE4ED tm223_human Transmembrane protein 223 TMEM223 protein protein human Homo sapiens Human MAAPWRRWPTGLLAVLRPLLTCRPLQGTTLQRDVLLFEHDRGRFFTILGLFCAGQGVFWASMAVAAVSRPPVPVQPLDAEVPNRGPFDLRSALWRYGLAVGCGAIGALVLGAGLLFSLRSVRSVVLRAGGQQVTLTTHAPFGLGAHFTVPLKQVSCMAHRGEVPAMLPLKVKGRRFYFLLDKTGHFPNTKLFDNTVGAYRSL A233432FF880DAAC atp5h_human ATP synthase subunit d, mitochondrial ATP5PD ATP synthase peripheral stalk subunit d ATP5H My032 protein protein human Homo sapiens Human MAGRKLALKTIDWVAFAEIIPQNQKAIASSLKSWNETLTSRLAALPENPPAIDWAYYKANVAKAGLVDDFEKKFNALKVPVPEDKYTAQVDAEEKEDVKSCAEWVSLSKARIVEYEKEMEKMKNLIPFDQMTIEDLNEAFPETKLDKKKYPYWPHQPIENL E93020ADA1BA1694 nduc2_human NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 HLC1 NADH-ubiquinone oxidoreductase subunit B14.5b Complex I-B14.5b Human lung cancer oncogene 1 protein protein protein human Homo sapiens Human MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR 9A47DEE33DC9244D cox16_human Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial COX16 C14orf112 HSPC203 PTD019 protein protein human Homo sapiens Human MFAPAVMRAFRKNKTLGYGVPMLLLIVGGSFGLREFSQIRYDAVKSKMDPELEKKLKENKISLESEYEKIKDSKFDDWKNIRGPRPWEDPDLLQGRNPESLKTKTT EB84EE268DF62B07 atpo_human ATP synthase subunit O, mitochondrial ATP5PO ATP synthase peripheral stalk subunit OSCP ATP5O ATPO Oligomycin sensitivity conferral protein protein protein human Homo sapiens Human MAAPAVSGLSRQVRCFSTSVVRPFAKLVRPPVQVYGIEGRYATALYSAASKQNKLEQVEKELLRVAQILKEPKVAASVLNPYVKRSIKVKSLNDITAKERFSPLTTNLINLLAENGRLSNTQGVVSAFSTMMSVHRGEVPCTVTSASPLEEATLSELKTVLKSFLSQGQVLKLEAKTDPSILGGMIVRIGEKYVDMSVKTKIQKLGRAMREIV 311F53576A31FC93 tmm65_human Transmembrane protein 65 TMEM65 protein protein human Homo sapiens Human MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS D24964048FF24DF2 cx6b1_human Cytochrome c oxidase subunit 6B1 COX6B1 COX6B Cytochrome c oxidase subunit VIb isoform 1 protein protein human Homo sapiens Human MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWVTDWDEQRAEGTFPGKI 15C8B056491FB248 atpa_human ATP synthase subunit alpha, mitochondrial ATP5F1A ATP synthase F1 subunit alpha ATP5A ATP5A1 ATP5AL2 ATPM protein protein human Homo sapiens Human MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA DIP protein P25705 original sequence version: null DIP protein P25705 original sequence version: 136 AA47BBB8EDA77EAC ndua9_human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NADH-ubiquinone oxidoreductase 39 kDa subunit Complex I-39kD NDUFA9 NDUFS2L protein protein human Homo sapiens Human MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPCRQLHHALMPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFASMHRFGPIPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVNI DIP protein Q16795 original sequence version: 88 66A1CC7FCE86DD0E cox11_human Cytochrome c oxidase assembly protein COX11, mitochondrial COX11 protein protein human Homo sapiens Human MGGLWRPGWRCVPFCGWRWIHPGSPTRAAERVEPFLRPEWSGTGGAERGLRWLGTWKRCSLRARHPALQPPRRPKSSNPFTRAQEEERRRQNKTTLTYVAAVAVGMLGASYAAVPLYRLYCQTTGLGGSAVAGHASDKIENMVPVKDRIIKISFNADVHASLQWNFRPQQTEIYVVPGETALAFYRAKNPTDKPVIGISTYNIVPFEAGQYFNKIQCFCFEEQRLNPQEEVDMPVFFYIDPEFAEDPRMIKVDLITLSYTFFEAKEGHKLPVPGYN 1F2BD22E1E7DD52D dnjb1_human DnaJ homolog subfamily B member 1 DNAJB1 DNAJ1 HDJ1 HSPF1 Heat shock 40 kDa protein 1 Human DnaJ protein 1 DnaJ protein homolog 1 protein protein human Homo sapiens Human MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGEGLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI DIP protein P25685 original sequence version: 95 17545098B0C196DF vdac2_human Voltage-dependent anion-selective channel protein 2 VDAC2 Outer mitochondrial membrane protein porin 2 protein protein human Homo sapiens Human MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA F4EAE732E653637E scmc1_human Calcium-binding mitochondrial carrier protein SCaMC-1 SLC25A24 APC1 MCSC1 SCAMC1 Mitochondrial ATP-Mg/Pi carrier protein 1 Mitochondrial Ca(2+)-dependent solute carrier protein 1 Small calcium-binding mitochondrial carrier protein 1 Solute carrier family 25 member 24 protein protein human Homo sapiens Human MLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK F533D47B2457123F coa3_human Cytochrome c oxidase assembly factor 3 homolog, mitochondrial COA3 CCDC56 MITRAC12 Coiled-coil domain-containing protein 56 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa HSPC009 protein protein human Homo sapiens Human MASSGAGDPLDSKRGEAPFAQRIDPTREKLTPEQLHSMRQAELAQWQKVLPRRRTRNIVTGLGIGALVLAIYGYTFYSISQERFLDELEDEAKAARARALARASGS ED6E73527E9B6C3C tpc_human Mitochondrial thiamine pyrophosphate carrier SLC25A19 DNC MUP1 Mitochondrial uncoupling protein 1 Solute carrier family 25 member 19 protein protein human Homo sapiens Human MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCNVFHCMNRTASQR 57CE0F01D538B1BE cox3_human Cytochrome c oxidase subunit 3 MT-CO3 COIII COXIII MTCO3 Cytochrome c oxidase polypeptide III protein protein human Homo sapiens Human MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS DIP protein P00414 original sequence version: null A04385EF748B7C14 ndub8_human NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NADH-ubiquinone oxidoreductase ASHI subunit Complex I-ASHI NDUFB8 protein protein human Homo sapiens Human MAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI 518459D44965D202 atpb_human ATP synthase subunit beta, mitochondrial ATP5F1B ATP synthase F1 subunit beta ATP5B ATPMB ATPSB protein protein human Homo sapiens Human MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHSS 960C616A2252B91A rm48_human 39S ribosomal protein L48, mitochondrial Mitochondrial large ribosomal subunit protein mL48 CGI-118 HSPC290 MRPL48 protein protein human Homo sapiens Human MSGTLEKVLCLRNNTIFKQAFSLLRFRTSGEKPIYSVGGILLSISRPYKTKPTHGIGKYKHLIKAEEPKKKKGKVEVRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSLPEGVRLSVKEHTEEDFKGRFKARPELEELLAKLK 0663B1751B57FFF5 tim23_human Mitochondrial import inner membrane translocase subunit Tim23 TIMM23 TIM23 protein protein human Homo sapiens Human MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKGSLLQQSL C9A1BBEC703B6838 cox1_human Cytochrome c oxidase subunit 1 MT-CO1 COI COXI MTCO1 Cytochrome c oxidase polypeptide I protein protein human Homo sapiens Human MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS DIP protein P00395 original sequence version: null DBCBFE808650AE0D tim21_human Mitochondrial import inner membrane translocase subunit Tim21 TIMM21 TIM21-like protein, mitochondrial HSPC154 C18orf55 TIM21 protein protein human Homo sapiens Human MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCGLQYQKKTLRPRCILGVTQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFGESVKGYGEVTRRGRRQHVRFTEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGSGEYDFRYIFVEIESYPRRTIIIEDNRSQDD 7BA2694A9DCD9024 mpcp_human Phosphate carrier protein, mitochondrial SLC25A3 PHC OK/SW-cl.48 Phosphate transport protein Solute carrier family 25 member 3 protein protein human Homo sapiens Human MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTQ 78714C85931B22D5 78714C85931B22D5 ecsit_human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Protein SITPEC ECSIT protein protein human Homo sapiens Human MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPEPRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS 42AFEBFFA6953C80 rdh13_human Retinol dehydrogenase 13 RDH13 SDR7C3 Short chain dehydrogenase/reductase family 7C member 3 PSEC0082 UNQ736/PRO1430 protein protein human Homo sapiens Human MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGLEAPSVREQPLPR DC5C1A6E54F1E6CC cx6a2_human Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 COX6A COX6AH Cytochrome c oxidase polypeptide VIa-heart Cytochrome c oxidase subunit VIA-muscle protein protein human Homo sapiens Human MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFRPYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP 843AD80319891F1B rm14_human 39S ribosomal protein L14, mitochondrial MRPL14 RPML32 MRPL32 39S ribosomal protein L32, mitochondrial Mitochondrial large ribosomal subunit protein uL14m protein protein human Homo sapiens Human MAFFTGLWGPFTCVSRVLSHHCFSTTGSLSAIQKMTRVRVVDNSALGNSPYHRAPRCIHVYKKNGVGKVGDQILLAIKGQKKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIKTPIPTSLRKREGEYSKVLAIAQNFV 841360D2E84071A4 cox14_human Cytochrome c oxidase assembly protein COX14 COX14 C12orf62 protein protein human Homo sapiens Human MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM 974BBDFA78CF7C9A sfxn1_human Sideroflexin-1 SFXN1 protein protein human Homo sapiens Human MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL 47E03172F27990DB at5f1_human ATP synthase F(0) complex subunit B1, mitochondrial ATP5PB ATP synthase peripheral stalk-membrane subunit b ATP synthase proton-transporting mitochondrial F(0) complex subunit B1 ATP synthase subunit b ATP5F1 protein protein human Homo sapiens Human MLSRVVLSAAATAAPSLKNAAFLGPGVLQATRTFHTGQPHLVPVPPLPEYGGKVRYGLIPEEFFQFLYPKTGVTGPYVLGTGLILYALSKEIYVISAETFTALSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALVQKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINWVEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM 743B1C54BFFEBBBD cox7b_human Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase polypeptide VIIb COX7B protein protein human Homo sapiens Human MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVGRVTPKEWRNQ 1EE75BD1AA253E59 tmm70_human Transmembrane protein 70, mitochondrial TMEM70 protein protein human Homo sapiens Human MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK 6206F853D18F12DC coa1_human Cytochrome c oxidase assembly factor 1 homolog COA1 C7orf44 MITRAC15 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa protein protein human Homo sapiens Human MMWQKYAGSRRSMPLGARILFHGVFYAGGFAIVYYLIQKFHSRALYYKLAVEQLQSHPEAQEALGPPLNIHYLKLIDRENFVDIVDAKLKIPVSGSKSEGLLYVHSSRGGPFQRWHLDEVFLELKDGQQIPVFKLSGENGDEVKKE 24582046A282291C sfxn4_human Sideroflexin-4 Breast cancer resistance marker 1 SFXN4 BCRM1 protein protein human Homo sapiens Human MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVESIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPTVFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGVIPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRIAGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMVPFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV 77A08F150D241277 cia30_human Complex I intermediate-associated protein 30, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 NDUFAF1 CIA30 CGI-65 protein protein human Homo sapiens Human MALVHKLLRGTYFLRKFSKPTSALYPFLGIRFAEYSSSLQKPVASPGKASSQRKTEGDLQGDHQKEVALDITSSEEKPDVSFDKAIRDEAIYHFRLLKDEIVDHWRGPEGHPLHEVLLEQAKVVWQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQSALLYGTLSSEAPQDGESTRSGYCAMISRIPRGAFERKMSYDWSQFNTLYLRVRGDGRPWMVNIKEDTDFFQRTNQMYSYFMFTRGGPYWQEVKIPFSKFFFSNRGRIRDVQHELPLDKISSIGFTLADKVDGPFFLEIDFIGVFTDPAHTEEFAYENSPELNPRLFK 13D76605CC50DFF7 atpg_human ATP synthase subunit gamma, mitochondrial ATP5F1C ATP synthase F1 subunit gamma ATP5C ATP5C1 ATP5CL1 F-ATPase gamma subunit protein protein human Homo sapiens Human MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD 021A95168FD53E04 tidc1_human Complex I assembly factor TIMMDC1, mitochondrial Translocase of inner mitochondrial membrane domain-containing protein 1 UNQ247/PRO284 TIMMDC1 C3orf1 Protein M5-14 protein protein human Homo sapiens Human MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDEQQRISKDLANICKTAATAGIIGWVYGGIPAFIHAKQQYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWGWRTAVFVTIFNTVNTSLNVYRNKDALSHFVIAGAVTGSLFRINVGLRGLVAGGIIGALLGTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD 5AA6474C3ABCCFA2 cox6c_human Cytochrome c oxidase subunit 6C COX6C Cytochrome c oxidase polypeptide VIc protein protein human Homo sapiens Human MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSVK D09FEE0C0AA7A798 ocad2_human OCIA domain-containing protein 2 Ovarian carcinoma immunoreactive antigen-like protein OCIAD2 protein protein human Homo sapiens Human MASASARGNQDKDAHFPPPSKQSLLFCPKSKLHIHRAEISKIMRECQEESFWKRALPFSLVSMLVTQGLVYQGYLAANSRFGSLPKVALAGLLGFGLGKVSYIGVCQSKFHFFEDQLRGAGFGPQHNRHCLLTCEECKIKHGLSEKGDSQPSAS B2278F751BA03A3E sco1_human Protein SCO1 homolog, mitochondrial SCO1 SCOD1 protein protein human Homo sapiens Human MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGYCLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKS DIP protein O75880 original sequence version: 79 C4A0F35A1741894F adt3_human ADP/ATP translocase 3 SLC25A6 ANT3 CDABP0051 Adenine nucleotide translocator 3 ADP,ATP carrier protein 3 Solute carrier family 25 member 6 ADP,ATP carrier protein, isoform T2 AAC3 protein protein human Homo sapiens Human MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 18534E9F0E49672F ucri_human Cytochrome b-c1 complex subunit Rieske, mitochondrial Ubiquinol-cytochrome c reductase iron-sulfur subunit Rieske iron-sulfur protein Complex III subunit 5 Rieske protein UQCRFS1 UQCRFS1 Cytochrome b-c1 complex subunit 5 protein protein human Homo sapiens Human MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG 8DB51634DEB039B0 surf1-coa3 1 49 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait c-terminal zz tag zz tag ZZ tag ZZ tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 1A surf1-coa3-1 3 49 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait c-terminal zz tag zz tag ZZ tag ZZ tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 1E Minute amounts of COX1 were also coisolated coa3-mt_co1-6 5 56 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait association association Fig. 1F coa3-mt_co1 3 49 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 56 unspecified role unspecified role prey prey physical association physical association Fig. 1G, 1I participants seperated both by SDS-PAGE and BN-PAGE coa3-mt_co1-7 3 27 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 56 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey association association Fig. 3A, 3D, Supp. Fig. 1A cox4i1-mt_co1 4 56 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component physical association physical association Fig. 1H coa3-mt_co1-2 4 56 unspecified role unspecified role neutral component neutral component 49 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 1H cox4i1-mt_co1-1 4 44 unspecified role unspecified role neutral component neutral component 56 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component physical association physical association Fig. 1H coa3-mt_co1-3 4 49 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 56 unspecified role unspecified role neutral component neutral component region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association Supp Fig. 1B coa3-b4drs6 1 32 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 51 unspecified role unspecified role prey prey 68 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 73 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 51 unspecified role unspecified role prey prey 57 unspecified role unspecified role prey prey 56 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 39 unspecified role unspecified role prey prey 9 unspecified role unspecified role prey prey 63 unspecified role unspecified role prey prey 70 unspecified role unspecified role prey prey 58 unspecified role unspecified role prey prey 8 unspecified role unspecified role prey prey 38 unspecified role unspecified role prey prey 36 unspecified role unspecified role prey prey 69 unspecified role unspecified role prey prey 64 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 59 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey 60 unspecified role unspecified role prey prey 28 unspecified role unspecified role prey prey 72 unspecified role unspecified role prey prey 29 unspecified role unspecified role prey prey 45 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 46 unspecified role unspecified role prey prey 33 unspecified role unspecified role prey prey 74 unspecified role unspecified role prey prey 67 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey association association Figure 3B and Table S1 MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15 coa3-coa1-1 3 61 unspecified role unspecified role prey prey 63 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 68 unspecified role unspecified role prey prey 57 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 56 unspecified role unspecified role prey prey association association Fig. 3C cox14-mt_co1 3 63 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 56 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey association association Fig. 3D coa3-cox14 4 49 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 56 unspecified role unspecified role neutral component neutral component 63 unspecified role unspecified role neutral component neutral component physical association physical association Fig. 3E Proteins first isolated by anti-Flag coimmunoprecipitation coa1-coa3 3 56 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 49 unspecified role unspecified role prey prey 68 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 57 unspecified role unspecified role prey prey 52 unspecified role unspecified role prey prey association association Fig. 4B cmc1-coa3-1 4 56 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 49 unspecified role unspecified role neutral component neutral component physical association physical association Fig. 4E Proteins first isolated by anti-Flag coimmunoprecipitation cmc1-coa3-2 3 49 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 56 unspecified role unspecified role prey prey association association Fig. 4F acad9-atp5a1 2 26 unspecified role unspecified role neutral component neutral component 59 unspecified role unspecified role neutral component neutral component 40 unspecified role unspecified role neutral component neutral component 65 unspecified role unspecified role neutral component neutral component 30 unspecified role unspecified role neutral component neutral component 47 unspecified role unspecified role neutral component neutral component 71 unspecified role unspecified role neutral component neutral component 18 unspecified role unspecified role neutral component neutral component 37 unspecified role unspecified role neutral component neutral component 53 unspecified role unspecified role neutral component neutral component 6 unspecified role unspecified role neutral component neutral component 20 unspecified role unspecified role neutral component neutral component 31 unspecified role unspecified role neutral component neutral component 43 unspecified role unspecified role neutral component neutral component 22 unspecified role unspecified role neutral component neutral component association association Fig. 5B, Supp Table 2 Cluster 1 c4orf52-cmc1 2 9 unspecified role unspecified role neutral component neutral component 76 unspecified role unspecified role neutral component neutral component 56 unspecified role unspecified role neutral component neutral component 36 unspecified role unspecified role neutral component neutral component 57 unspecified role unspecified role neutral component neutral component 63 unspecified role unspecified role neutral component neutral component 15 unspecified role unspecified role neutral component neutral component 19 unspecified role unspecified role neutral component neutral component 12 unspecified role unspecified role neutral component neutral component 34 unspecified role unspecified role neutral component neutral component 60 unspecified role unspecified role neutral component neutral component 11 unspecified role unspecified role neutral component neutral component 54 unspecified role unspecified role neutral component neutral component association association Fig 5B, Supp. Table 2 Cluster 2 cox4i1-cox5a-1 2 32 unspecified role unspecified role neutral component neutral component 23 unspecified role unspecified role neutral component neutral component 35 unspecified role unspecified role neutral component neutral component 24 unspecified role unspecified role neutral component neutral component 42 unspecified role unspecified role neutral component neutral component 51 unspecified role unspecified role neutral component neutral component 66 unspecified role unspecified role neutral component neutral component 75 unspecified role unspecified role neutral component neutral component 7 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component 33 unspecified role unspecified role neutral component neutral component 73 unspecified role unspecified role neutral component neutral component association association Fig. 5B, Supp Table 2 Cluster 3 cox15-mrpl14 2 25 unspecified role unspecified role neutral component neutral component 64 unspecified role unspecified role neutral component neutral component 50 unspecified role unspecified role neutral component neutral component 58 unspecified role unspecified role neutral component neutral component 62 unspecified role unspecified role neutral component neutral component 41 unspecified role unspecified role neutral component neutral component 48 unspecified role unspecified role neutral component neutral component 69 unspecified role unspecified role neutral component neutral component 21 unspecified role unspecified role neutral component neutral component 14 unspecified role unspecified role neutral component neutral component association association Fig. 5B, Supp. Table 2 Cluster 4 timm23-timm21 3 55 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 57 unspecified role unspecified role prey prey physical association physical association Fig. 5E timm21-coa1 3 68 unspecified role unspecified role prey prey 49 unspecified role unspecified role prey prey 57 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range association association Fig. 5F coa3-mt_co1-4 3 56 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 57 unspecified role unspecified role prey prey association association Fig. 5D participants seperated both by SDS-PAGE and BN-PAGE timm23-timm50 3 21 unspecified role unspecified role prey prey 55 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Supp Fig. 2A timm21-coa3-2 3 57 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 21 unspecified role unspecified role prey prey 56 unspecified role unspecified role prey prey 49 unspecified role unspecified role prey prey 52 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 55 unspecified role unspecified role prey prey association association Fig. 6D co6a-cox5a 3 61 unspecified role unspecified role prey prey 77 unspecified role unspecified role prey prey 57 unspecified role unspecified role prey prey 56 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 73 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 49 unspecified role unspecified role prey prey 52 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey association association Fig. 6E cox6a2-coa3 3 44 unspecified role unspecified role prey prey 49 unspecified role unspecified role prey prey 35 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 56 unspecified role unspecified role prey prey 61 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range association association Fig. 6F coa3-mt_co1-5 3 56 unspecified role unspecified role prey prey 49 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 7B timm21-coa3-1 3 57 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range 56 unspecified role unspecified role prey prey association association Fig. 7B timm21-coa1-1 3 56 unspecified role unspecified role prey prey 49 unspecified role unspecified role prey prey 68 unspecified role unspecified role prey prey 55 unspecified role unspecified role prey prey 57 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range association association Fig. 7E, 7B. When the synthesis of mitochondria-encoded proteins was inhibited by thiamphenicol, the interaction of TIM21 with COX1 and MITRAC12 was strongly reduced without influencing the interaction with TIM23. Blocking cytosolic translation with emetine and concomitantly import of nuclear-encoded subunits reduced the interaction between TIM21 and TIM23, whereas the interaction with COX1 and MITRAC12 remained unaffected.