UniProt UniProt http://www.uniprot.org Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies. Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies. J. Virol. (0022-538X) 2011 imex curation Maroui M.A., Pampin M., Chelbi-Alix M.K. mounira.chelbi-alix@parisdescartes.fr 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-u373_mg Human glioblastoma astrocytoma u373_mg Human glioblastoma astrocytoma confocal microscopy confocal microscopy immunostaining immunostaining Maroui M.A., Pampin M., Chelbi-Alix M.K. mounira.chelbi-alix@parisdescartes.fr Accepted 2013-JUN-05 by ORCHARD 17-Jun-2013: Contacted by IntAct-Help. J. Virol. (0022-538X) 2011 Only protein-protein interactions imex curation Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies. Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies. J. Virol. (0022-538X) 2011 imex curation Maroui M.A., Pampin M., Chelbi-Alix M.K. mounira.chelbi-alix@parisdescartes.fr 17-Jun-2013: Contacted by IntAct-Help. Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Maroui M.A., Pampin M., Chelbi-Alix M.K. mounira.chelbi-alix@parisdescartes.fr Accepted 2013-JUN-05 by ORCHARD 17-Jun-2013: Contacted by IntAct-Help. J. Virol. (0022-538X) 2011 Only protein-protein interactions imex curation p03304-pro_0000039791 RNA-directed RNA polymerase protein protein emcv Encephalomyocarditis virus GALERLPDGPRIHVPRKTALRPTVARQVFQPAYAPAVLSKFDPRTEADVDEVAFSKHTSNQESLPPVFRMVAKEYANRVFTLLGKDNGRLTVKQALEGLEGMDPMDRNTSPGLPYTALGMRRTDVVDWESATLIPFAAERLRKMNEGDFSEVVYQTFLKDELRPIEKVQAAKTRIVDVPPFEHCILGRQLLGKFASKFQTQPGLELGSAIGCDPDVHWTAFGVAMQGFERVYDVDYSNFDSTHSVAMFRLLAEEFFTPENGFDPLTREYLESLAISTHAFEEKRFLITGGLPSGCAATSMLNTIMNNIIIRAGLYLTYKNFEFDDVKVLSYGDDLLVATNYQLDFDKVRASLAKTGYKITPANTTSTFPLNSTLEDVVFLKRKFKKEGPLYRPVMNREALEAMLSYYRPGTLSEKLTSITMLAVHSGKQEYDRLFAPFREVGVVVPSFESVEYRWRSLFW 1831 2290 50D7DF1434CAB5D2 p29590-5 Protein PML PML MYL RNF71 TRIM19 RING finger protein 71 Tripartite motif-containing protein 19 PML-IV PML-X TRIM19zeta Promyelocytic leukemia protein PP8675 E3 SUMO-protein ligase PML RING-type E3 SUMO transferase PML protein protein human Homo sapiens Human MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYRQIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPEEAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENLADPQAEDRPLVFFDLKIDNESGFSWGYPHPFLI DIP protein P29590-5 original sequence version: 188 DIP protein P29590-5 original sequence version: 195 85FBAEC9F162C8E0 p03304_pro-pml 1 4 unspecified role unspecified role neutral component neutral component nucl transfection nucleic acid transfection nucl transfection P29590-5:p.[Lys65Ala;Lys160Ala;Lys490Ala] mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain K A Wed May 02 19:25:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys65ala,lys160ala,lys490ala' Tue Jun 30 15:48:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys65Ala;Lys160Ala;Lys490Ala]' c-terminal required to bind necessary binding region required to bind mutation analysis mutation analysis certain certain sequence position certain less-than less-than 3 unspecified role unspecified role neutral component neutral component nucl transfection nucleic acid transfection nucl transfection colocalization colocalization 5A and B, 6B pml-p03304_pro 2 4 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection 3 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection physical association physical association 5C p03304_pro-pml-1 2 3 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection 4 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection c-terminal required to bind necessary binding region required to bind mutation analysis mutation analysis certain certain sequence position certain less-than less-than physical association physical association 5C and 6C