IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions drome-schneider_2 Drosophila melanogaster late embryo cells Fruit fly schneider_2 Established from the late embryo of Drosophila melanogaster Mixture of diploid and tetraploid. Originally had some XY cells now predominantly XX. ch-ip chromatin immunoprecipitation assay ch-ip nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions drome-salivary_gland Drosophila melanogaster Salivary gland salivary_gland Salivary gland fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Drosophila embryonic cDNA Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. (0270-7306) 2010 imex curation Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip ms participant Identification by mass spectrometry ms participant Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Accepted 2012-SEP-18 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation hair_drome_gene Hairy gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly q0e8g1_drome simj 68-like Dmel\CG32067 SIMJ anon-WO0118547.361 dp66 l(3)01814 l(3)j4A5 l(3)rN672 p66 Dmel_CG32067 CG7983 CG8000 CG32067 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MAKMEVDDVVDLSLGSGRDPALTITPAPPPAALSNRDLRALTANNAGLTITPSASPATNNGTTSNSSNTNSNSSSTTTTTNNNNNSSSNTNSSSANNNNNNNSINASDGVTGATSGSIGGGQDENKVQRRVLRPRTEPKSYAEAPDIVLLPARTNGRQQNGNIDSETDDEEMPPYVPIKELSHAELKEREKSLRKLRQDLRNEETKLMLLKKLKQSQQVMKENLVVTPTSVSPNNPLSAIPAALTSKGSLSVTPTSAVPLPAHSKGSRSSLSGSGGPAVSISATNSRTGSSSSAAAAASAIAAAAMSGQHRSGSNSILPPPRSSLPAGATLAAGTTITPATSSSHRSSNLPPRTNLPNLTITPSVTITPTSAPPSSLKPRNVPGTISNSVSITPALPLSQSHQNQHNDQKNDRSTPREDAQTPAQRQAAAKMALRKQLEKTLLQIPPPKPPPPEMHFIPNPSNTDFVYLLGLETVVDYLTVNKKANAVAAPFRCAQCKIDFTPVWKWEKQTNKDPKVICEQCVTSNVKKALKAEHTNRLKQAFVKALQQEQEIEQRLASQSSPSPVDNHGSSGGGNSLSVSAVSSNSSSSHMQREREQLQASHASAAAALVNLPPSVTVIPTKCQTPTPATPRPTPPPPQSQATPPPSSGGSRSSRAAATAAAAAIAAQQAGILSPGPSPAHHHEPTTSSRSSRNDRLDHHHQSQQQQQRDQRERDQQQRDQQSQQQAQNYDKYSAATLAAAAHLSALGGMGGLNINSLASLGNLGNLGNLSQLGNLAALGGLGNFGGASTGSANPAAGLSGSSPAATAAAMQAFQQQLFRALGQGLGGNPQHMMQFAPLLYSYQMAMAQAAQVAAFNNNNKKSSSSSGSAKNSSSSNSMAEVQRAAELQRQYLLEMIPPQQQSGASGSRQNNWKA A821EAA45E2B8306 ctbp_drome C-terminal-binding protein CtBP CG7583 dCtBP protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGALHHRAHSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVPSHLSPQVGGLPLGIVSSQSPLSAPDPNNHLSSSIKTEVKAESTEAP DIP protein O46036 original sequence version: 97 DD5F85535BEB56C1 q9vhb7_drome 3 Dm Mbd2 DmMbd2 Dmel\CG8208 MBD2 MBD2-3 MBD3 dMBD-like dMBD2 dMbD2 Dmel_CG8208 MBD-like CG8208 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSPTGKRAEGKPQDIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT B745DA7EE88D0A85 ark_drome_gene Apaf-1 related killer DARK gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly q9biw6_drome Bap111 dalao CG7055 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MALPSNYKQIAVGGQGSATPLQGGGGGSGGGSRSRSSGGGGGGDRNKDQTPIFTHSNYGNPAFTPQKVTKSSSSKNQNESRLPKPPKPPEKPILPYMRYSKRVWDSVKAKHPELKLWELGKKIGAMWKLLPEDEKTEFIDEYEAEKLEYEKSLKAYHQTPAYQAYMSAKSKVKTDVDMHETPSRGGGSKSQHERRIDIQPAEDEDDQDEGYTTKHLAYARYLHNHRLINEIFSEAVVPDVRSVVTTTRMQVLKRQVSSLTMHQTKLEAELQQMEEKFEAKKQRMVESSEAFQEELKRHCKPAVDEETFQKMVLRMYEDIKRDRQRLDEPNANANSAANPAAAAATAAAAPVTRSEEAVKPPTQPGQPAATPAGQEPASAVPAPAAPPKETPPAVKPATLNPTPSSTPTPAPAVHVHETASKTDPEPMDIEPPPKPSVPPPPIKPEKLEMAAALPPQSTLVEPPKTEPAKVVAQPGKVPTPVPTPTPPPEVAPAAGAVTAATTTTRRTPTPPPVPQQVPLPQQQGGPAPPPGMPQMHPHPGHPPPGHSLMPPHMGPHQPPPGMPGLPPPPPHTGYANYGGPPHGPPPGPPGGPARPYYQPQYGGHPTPQPYYAPFSPYQQSYGPPPGSHYMSPRPPPPQHNGNPGHPYAPEHGSNPPPPQQQQQQQPPPGHLHEPSGGGPGAPGGGAGAAAAAAPGAGVYPTPGAGAGPGAPPGPAGGAPLGEAAVAGGVGPPAATALGKHPEAEKHEAD DIP protein Q9BIW6 original sequence version: 53 6717C5F3774D9790 hmen_drome_gene Segmentation polarity homeobox protein engrailed gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly q9vnf6_drome MTA1-like Dmel\CG2244 MTA MTA-like MTA1 dMTA dMTA-1 dMTA1-like p120 Dmel_CG2244 CG2244 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLATAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIVPSGPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAPDDVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIKPAAPEPSSRPIESQIVILD 7E8F2753F85C3717 q0e8j0_drome MEP-1 Dmel\CG1244 MEP1 Q0E8J0_DROME anon-EST:Liang-1.37 anon-WO0118547.584 clone 1.37 dMEP-1 Dmel_CG1244 CG1244 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MTEVDVVLPEGVAEPTTKLASASSSPKQSKPSADDVEQQVTTVEDDEEQVVEEQQEEDVHLPEAPSNEKLELLSAGGKDISKEDVAQASPQAPVADEIMEVDGTEDVEENEVENDDEDSQITSSSSKEPKLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLDGEESVASEGVVEEEPPAKQENGFGASPNQKENGQASIAEARAAIAPSDGGVVNLDEDSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKMRKAQVQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTAHSTVARKAMDSKKNSAQSSGSGSGAGMSRSSLGAANDSLLKPLKINDEITIIPQPASKPRITNMESHVID 646324FE7D92954D hdac1_drome Histone deacetylase HDAC1 HDAC1 Rpd3 CG7471 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKENNI DIP protein Q94517 original sequence version: 67 B0F6503D42A1BCE9 q9w321_drome Histone acetyltransferase nej CBP CBP_ Cbp Crbp Dmel\CG15319 Nej Nejire anon-WO0147981.11 anon-WO03040301.89 cbp dCBP dKAT3 dmCBP l(1)G0112 l(1)G0350 l(1)G0470 nej CBP p300 CG15321 Dmel_CG15319 CG15319 P300 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MMADHLDEPPQKRVKMDPTDISYFLEENLPDELVSSNSGWSDQLTGGAGGGNGGGGASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGSGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQGGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVLTNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQHMLRGPHLMGASGGAGGPGNGPGGGGPRMQNPNMQMTQLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGPGGANRDVPDDRKRQIQQQLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNGPQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTVPGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQQMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRAAPSASPRAQPSPHHVMSSHSPAPQGPPHDGMHNHGMHHQSPLPGVPQDVGVGVGVGVGVGVNVNVGNVGVGNAGGALPDASDQLTKFVERL DIP protein Q9W321 original sequence version: 94 C9D4611ACBD3918A q9v424_drome CG8208 MBD-like 3 Dm Mbd2 DmMbd2 Dmel\CG8208 MBD2 MBD2-3 MBD3 dMBD-like dMBD2 dMbD2 Dmel_CG8208 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT 26F2DD296442B4D3 caf1_drome Chromatin assembly factor 1 p55 subunit Caf1-55 CAF-1 Caf1 Nucleosome-remodeling factor 55 kDa subunit CG4236 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNTA DIP protein Q24572 original sequence version: 142 DIP protein Q24572 original sequence version: 124 90C5FB959F1660D5 q9w4w7_drome MAD Dmel\CG2662 EG:100G10.6 snuts CG2662 Dmel_CG2662 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MKQSKDEDKEESPVQPTTHNSSAGSNGHDAKSPVVTTAPAATCSVSVSDASGAGASVRTTGRVKKPKQVYDPSDNYVSRASSNRNSLSSVPATSNVQSPPVKEATDSQDSTTSPVSEQQQQQLQQAAQLRNFDTCQKCGKSEPKRGSGHKSNFLTCKGCMQKWHFPCLPITFHNQSTARKKFKCDKCRYCRLCNVRGPGLSICSLCVDAYHPDCNDPTLKQSKAVEANPNWRCFRCEACNIGGSTSASSEEQTGARKSTASREDQAQPVVPRKSNAGRKKRVQSEPTGQEKAAKIEKLAKRRQPLKTEKKKEYKKEEDEEPAQIKVKVEKVEPVDMETEQIENNDLPGPEQESLSLRLTPITAVERRSHPVSTWSVEQVVQFVAKRYPKEANVFRYQDIDGASLLLLNRHDVMNGFGLKLGPALRVFELVMSLQTQSNDVGLAWLD 2C1BDE6EA07E78C6 sk1_drome_gene Sphingosine kinase 1 gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly kcnq_drome_gene KCNQ potassium channel gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly chdm_drome Chromodomain-helicase-DNA-binding protein Mi-2 homolog Mi-2 CG8103 ATP-dependent helicase Mi-2 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFSVPGQLSNNSGV ED8E256D1AD0AC2F ttkb_drome Protein tramtrack, beta isoform ttk FTZ-F2 Repressor protein fushi tarazu Tramtrack p69 CG1856 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MKMASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSDGNDSDGEGLDTSYMEPQLMLDEYDEPVEFKYNPLTDNSSPTQDHTDGSHLNEQARQQAFLIAAQRKHQVETAAAAAASGIKLNIIGMAAGGAQVKSMVSIPKLTPIGKVNAASTPLVSPAGSFSTATVKPRVQKRPKLGKQNGDVKPAVFSSQEYLDIYNSNDGFKLKAAGLSGSTPNLSAGLGTPSVKTKLNLSSNVGEGEAEGSVRDYCTKEGEHTYRCKVCSRVYTHISNFCRHYVTSHKRNVKVYPCPFCFKEFTRKDNMTAHVKIIHKIENPSTALATVAAANLAGQPLGVSGASTPPPPDLSGQNSNQSLPATSNALSTSSSSSTSSSSGSLGPLTTSAPPAPAAAAQ 98DAEA1A5E97DC59 q9vz27_drome CDK2AP1 CG18292-RA DOC1 Dmel\CG18292 anon-WO03040301.144 Dmel_CG18292 CG18292 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MDIMDIQAVESKLSDVTVTPIPRSQVQNFYNYQQQREQREQQPQIQISAIHHSRGSVGGGGGSNSSNAATDYSTSSGGKRERDRSSASDYSSSSSKQSSAAAANAAAAAAAVAALQYSPQFLQAQLALLQQQSNTTATPAAVAAAALSLANMCSSNGGQRNSGAGVSSTSSGSNGQSMGLNLSSSQLKYPPPSTSPVVVTTQTSANITTPLTSTASLPSVGPGNGLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHARILVRECLMETERAARQ B9577D480BB0CE9F ttk-mep_1 5 16 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 25 unspecified role unspecified role bait bait physical association physical association text, fig 1A ttk-mep_1-1 6 16 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 25 unspecified role unspecified role bait bait region required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain 35 33 physical association physical association Fig. 1B mep_1-ttk 4 25 unspecified role unspecified role prey prey in vitro In vitro 16 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) physical association physical association Fig. 1C mep_1-caf1-3 7 20 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait 25 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 9 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey association association Fig. 2A, Table 1 mi_2-caf1 7 19 unspecified role unspecified role prey prey 24 unspecified role unspecified role bait bait 15 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 9 unspecified role unspecified role prey prey association association Fig. 2B, Table 1 mi_2-chdm-1 3 24 unspecified role unspecified role bait bait 26 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey association association Fig. 2C mep_1-caf1-1 3 15 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait association association Fig. 2C mi_2-cg18292_ra 3 17 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey 26 unspecified role unspecified role bait bait 16 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 15 unspecified role unspecified role prey prey association association Fig. 2D, 2E Immunodepletion of CDK2AP1/DOC1resulted in the concomitant loss of Mi2, MEP1, MTA1, and, to a somewhat lesser extent, RPD3 mep_1-ttk-1 2 25 unspecified role unspecified role neutral component neutral component 16 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig. 4 mi_2-ttk-1 2 24 unspecified role unspecified role neutral component neutral component 25 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig. 4 ttk-ark 1 12 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig. 6B Depletion of either MEP1 or Mi2 did not affect TTK69 binding to the gene loci. ttk-hair 1 25 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey association association Fig. 6B Depletion of either MEP1 or Mi2 did not affect TTK69 binding to the gene loci. ttk-hmen 1 14 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait association association Fig. 6B Depletion of either MEP1 or Mi2 did not affect TTK69 binding to the gene loci. mi_2-ark 1 24 unspecified role unspecified role bait bait 12 unspecified role unspecified role prey prey association association Fig. 6C Depletion of either MEP1 or TTK69 caused reduced MI-2 binding to the gene loci. mi_2-hair 1 24 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey association association Fig. 6C Depletion of either MEP1 or TTK69 caused reduced MI-2 binding to the gene loci. mi_2-hmen 1 14 unspecified role unspecified role prey prey 24 unspecified role unspecified role bait bait association association Fig. 6C Depletion of either MEP1 or TTK69 caused reduced MI-2 binding to the gene loci. mep_1-ark 1 12 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait association association Fig. 6D MEP1 binding was strictly dependent on TTK69 however, loss of Mi2 only modestly affected MEP1 recruitment to the gene loci. mep_1-hair 1 8 unspecified role unspecified role prey prey 16 unspecified role unspecified role bait bait association association Fig. 6D MEP1 binding was strictly dependent on TTK69 however, loss of Mi2 only modestly affected MEP1 recruitment to the gene loci. mep_1-hmen 1 16 unspecified role unspecified role bait bait 14 unspecified role unspecified role prey prey association association Fig. 6D MEP1 binding was strictly dependent on TTK69 however, loss of Mi2 only modestly affected MEP1 recruitment to the gene loci. dalao-sk1 1 22 unspecified role unspecified role prey prey 13 unspecified role unspecified role bait bait association association Fig. 6E BAP111 binding to its targets SK1 and KCNQ was unaffected by the knockdown of TTK69, MEP1, or Mi2 dalao-kcnq 1 13 unspecified role unspecified role bait bait 23 unspecified role unspecified role prey prey association association Fig. 6E BAP111 binding to its targets SK1 and KCNQ was unaffected by the knockdown of TTK69, MEP1, or Mi2