UniProt UniProt http://www.uniprot.org ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem. Biophys. Res. Commun. (0006-291X) 2003 imex curation Masumoto J., Dowds T.A., Schaner P., Chen F.F., Ogura Y., Li M., Zhu L., Katsuyama T., Sagara J., Taniguchi S., Gumucio D.L., Nunez G., Inohara N. Origin of Casp8 according the used catalytically inactive mutant construct ino@umich.edu 11-Oct-2012: Contacted by IntAct-Help. Only protein-protein interactions human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Masumoto J., Dowds T.A., Schaner P., Chen F.F., Ogura Y., Li M., Zhu L., Katsuyama T., Sagara J., Taniguchi S., Gumucio D.L., Nunez G., Inohara N. Origin of Casp8 according the used catalytically inactive mutant construct ino@umich.edu Accepted 2012-SEP-17 by PPORRAS 11-Oct-2012: Contacted by IntAct-Help. Biochem. Biophys. Res. Commun. (0006-291X) 2003 Only protein-protein interactions imex curation nlrc4_human NLR family CARD domain-containing protein 4 NLRC4 CLAN CLAN1 UNQ6189/PRO20215 CARD12 IPAF Caspase recruitment domain-containing protein 12 Ice protease-activating factor CARD, LRR, and NACHT-containing protein protein protein human Homo sapiens Human MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA 49378DBB54938E0F asc_human Apoptosis-associated speck-like protein containing a CARD PYD and CARD domain-containing protein Target of methylation-induced silencing 1 Caspase recruitment domain-containing protein 5 ASC CARD5 TMS1 PYCARD protein protein human Homo sapiens Human MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS DIP protein Q9ULZ3 original sequence version: 116 455987286586F46A q14790-4 Caspase-8 Alpha-4 CASP8 MCH5 Apoptotic cysteine protease Apoptotic protease Mch-5 CAP4 FADD-homologous ICE/ced-3-like protease FADD-like ICE ICE-like apoptotic protease 5 MORT1-associated ced-3 homolog protein protein human Homo sapiens Human MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD 68136650A49159D9 pycard-casp8-1 1 3 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection fpk3 fusion protein fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range n-terminal required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain c-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range 4 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection Q14790-4:p.Cys377Ser mutation mutation certain certain sequence position certain certain certain sequence position certain C S Wed May 02 14:31:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys377ser' Tue Jun 30 18:06:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys377Ser' c-terminal ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association 2F nlrc4-casp8 1 3 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection 4 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection c-terminal ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q14790-4:p.Cys377Ser mutation mutation certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:36:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys377ser' Tue Jun 30 20:05:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys377Ser' 2 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain c-terminus myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range association association 3C PYCARD/ASC has been detected with anti-ASC antibody. MEFV/Pyrin