IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (0092-8674) 2011 imex curation Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. alt@enders.tch.harvard.edu, ub2121@columbia.edu 26-Jun-2011: Contacted by JYOTI. jyoti Only protein-protein interactions mouse-b-cell lymphoma Mus musculus B-cell lymphoma b-cell lymphoma B-cell lymphoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. alt@enders.tch.harvard.edu, ub2121@columbia.edu Accepted 2011-JUL-2 by JYOTI. 26-Jun-2011: Contacted by JYOTI. Cell (0092-8674) 2011 jyoti Only protein-protein interactions imex curation The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (0092-8674) 2011 imex curation Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. alt@enders.tch.harvard.edu, ub2121@columbia.edu 26-Jun-2011: Contacted by JYOTI. jyoti Only protein-protein interactions human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. Origin of constructs confirmed by the author. alt@enders.tch.harvard.edu, ub2121@columbia.edu Accepted 2011-JUL-2 by JYOTI. 26-Jun-2011: Contacted by JYOTI. Cell (0092-8674) 2011 jyoti Only protein-protein interactions imex curation The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (0092-8674) 2011 imex curation Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. alt@enders.tch.harvard.edu, ub2121@columbia.edu 26-Jun-2011: Contacted by JYOTI. jyoti Only protein-protein interactions human-ramos Human Caucasian Burkitt's lymphoma ramos Human Caucasian Burkitt's lymphoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. DNA-protein complexes were purified via chromatographic steps that would enrich for DNA binding (CM-sepharose, DEAE cellulose) and macromolecular complex formation (gel-filtration chromatography), followed by heparin sepharose chromatography and anti-AID antibody-mediated affinity purification to enrich complexes containing AID alt@enders.tch.harvard.edu, ub2121@columbia.edu Accepted 2011-JUL-2 by JYOTI. 26-Jun-2011: Contacted by JYOTI. Cell (0092-8674) 2011 jyoti Only protein-protein interactions imex curation The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (0092-8674) 2011 imex curation Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. alt@enders.tch.harvard.edu, ub2121@columbia.edu 26-Jun-2011: Contacted by JYOTI. jyoti Only protein-protein interactions human-ramos Human Caucasian Burkitt's lymphoma ramos Human Caucasian Burkitt's lymphoma anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. DNA-protein complexes were purified via chromatographic steps that would enrich for DNA binding (CM-sepharose, DEAE cellulose) and macromolecular complex formation (gel-filtration chromatography), followed by heparin sepharose chromatography and anti-AID antibody-mediated affinity purification to enrich complexes containing AID alt@enders.tch.harvard.edu, ub2121@columbia.edu Accepted 2011-JUL-2 by JYOTI. 26-Jun-2011: Contacted by JYOTI. Cell (0092-8674) 2011 jyoti Only protein-protein interactions imex curation The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (0092-8674) 2011 imex curation Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. alt@enders.tch.harvard.edu, ub2121@columbia.edu 26-Jun-2011: Contacted by JYOTI. jyoti Only protein-protein interactions mouse-b-cell Mus musculus B-cell b-cell B-cell [B lymphocyte; B-lymphocyte; B cell; B-cells] anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Basu U., Meng FL., Keim C., Grinstein V., Pefanis E., Eccleston J., Zhang T., Myers D., Wasserman CR., Wesemann DR., Januszyk K., Gregory RI., Deng H., Lima CD., Alt FW. Cells treated with anti-CD40 plus IL-4 alt@enders.tch.harvard.edu, ub2121@columbia.edu Accepted 2011-JUL-2 by JYOTI. 26-Jun-2011: Contacted by JYOTI. Cell (0092-8674) 2011 jyoti Only protein-protein interactions imex curation exos3_mouse Exosome complex component RRP40 Exosc3 Rrp40 Exosome component 3 Ribosomal RNA-processing protein 40 protein protein mouse Mus musculus Mouse MAEVLSAGPESVAGCRARAVHKVLNQVVLPGEELVLPDHEDVDGLGGAGEQPLRLNAGARPRLRVVCGPGLRRCGDRLLVTKCGRLRHKEPSGGGGGVYWVDSQQKRYVPVKGDHVIGIVIAKSGDIFKVDVGGSEPASLSYLAFEGATKRNRPNVQVGDLIYGQCVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIVQELGKLYPLEIVFGMNGRIWVKAKTIQQTLILANVLEACEHMTTEQRKQIFARLAES 0932E5B03DD708D4 rrp44_human Exosome complex exonuclease RRP44 DIS3 Ribosomal RNA-processing protein 44 Protein DIS3 homolog KIAA1008 RRP44 protein protein human Homo sapiens Human MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK 92336BA0D06247FE exos6_human Exosome complex component MTR3 EXOSC6 MTR3 Exosome component 6 mRNA transport regulator 3 homolog p11 protein protein human Homo sapiens Human MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP DIP protein Q5RKV6 original sequence version: 93 F31729E0D1545F94 exos5_mouse Exosome complex component RRP46 Ribosomal RNA-processing protein 46 Exosome component 5 Exosc5 D7Wsu180e Rrp46 protein protein mouse Mus musculus Mouse MEGAKRADANLLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLVRNTCEAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVTCALDSDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSTTKGLYSDAELQQCLAAAQAASQHIFRFYRESLQRRYSKS 08752915141CF65D aicda_mouse Single-stranded DNA cytosine deaminase Aicda Aid Cytidine aminohydrolase Activation-induced cytidine deaminase protein protein mouse Mus musculus Mouse MDSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSCSLDFGHLRNKSGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIGIMTFKDYFYCWNTFVENRERTFKAWEGLHENSVRLTRQLRRILLPLYEVDDLRDAFRMLGF DIP protein Q9WVE0 original sequence version: 66 18A3BA10CA54BEB2 exosx_human Exosome component 10 PMSCL2 EXOSC10 PMSCL Polymyositis/scleroderma autoantigen 2 Autoantigen PM/Scl 2 Polymyositis/scleroderma autoantigen 100 kDa P100 polymyositis-scleroderma overlap syndrome-associated autoantigen RRP6 protein protein human Homo sapiens Human MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEYDFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVILERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNIIRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADFIHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVELNEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR DIP protein Q01780 original sequence version: 154 A37BDC8F49BF2E57 exos7_human Exosome complex component RRP42 KIAA0116 RRP42 EXOSC7 Ribosomal RNA-processing protein 42 Exosome component 7 p8 protein protein human Homo sapiens Human MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG DIP protein Q15024 original sequence version: 123 DIP protein Q15024 original sequence version: 138 A674F745CEC61BBB exos3_human Exosome complex component RRP40 EXOSC3 RRP40 CGI-102 Ribosomal RNA-processing protein 40 Exosome component 3 p10 protein protein human Homo sapiens Human MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES DIP protein Q9NQT5 original sequence version: 130 DIP protein Q9NQT5 original sequence version: 72 DIP protein Q9NQT5 original sequence version: 117 DIP protein Q9NQT5 original sequence version: 136 264322144A199166 exos2_human Exosome complex component RRP4 EXOSC2 RRP4 Ribosomal RNA-processing protein 4 Exosome component 2 protein protein human Homo sapiens Human MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG DIP protein Q13868 original sequence version: 143 882033F50791643F aicda_human Single-stranded DNA cytosine deaminase AICDA AID Cytidine aminohydrolase Activation-induced cytidine deaminase protein protein human Homo sapiens Human MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL DIP protein Q9GZX7 original sequence version: 123 DIP protein Q9GZX7 original sequence version: 82 3C27BB143DB184A9 exos6_mouse Exosome complex component MTR3 Exosc6 Mtr3 Exosome component 6 mRNA transport regulator 3 homolog protein protein mouse Mus musculus Mouse MPGDHRRIRGPEESQPPQLYAAEDDETPAARDPTRLRPVYARAGLLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGSGPAGAGGEAPAALRGRLLCDFRRAPFSGRRRRAPQGGGGEDRELGLALQEALEPAVRLGRYPRAQLEVSALLLEDGGCALAAALTAAALALADAGVEMYDLVVGCGLSLTPGPSPTWLLDPTRLEEEHSAAGLTVALMPVLNQVAGLLGSGEGGQTESWTDAVRLGLEGCQRLYPVLQQCLVRAARRRGAAAPP 6AC4310F46742B10 exos5_human Exosome complex component RRP46 EXOSC5 CML28 RRP46 Ribosomal RNA-processing protein 46 Exosome component 5 p12B Chronic myelogenous leukemia tumor antigen 28 protein protein human Homo sapiens Human MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS DIP protein Q9NQT4 original sequence version: 123 DIP protein Q9NQT4 original sequence version: 66 DIP protein Q9NQT4 original sequence version: 112 DIP protein Q9NQT4 original sequence version: 129 DIP protein Q9NQT4 original sequence version: 105 C3C1FCB39D85B1EE exos4_human Exosome complex component RRP41 EXOSC4 RRP41 SKI6 Ribosomal RNA-processing protein 41 Exosome component 4 p12A protein protein human Homo sapiens Human MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD DIP protein Q9NPD3 original sequence version: 133 7A24E97897DAF313 exos1_human Exosome complex component CSL4 CSL4 EXOSC1 CGI-108 Exosome component 1 protein protein human Homo sapiens Human MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT DIP protein Q9Y3B2 original sequence version: 130 E9C3B0A66F911195 exos8_human Exosome complex component RRP43 OIP2 RRP43 EXOSC8 Ribosomal RNA-processing protein 43 Exosome component 8 p9 Opa-interacting protein 2 protein protein human Homo sapiens Human MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK DIP protein Q96B26 original sequence version: 125 FC8F5BAE74A1FF55 aicda-exosc1 4 15 unspecified role unspecified role bait bait 19 unspecified role unspecified role prey prey 12 unspecified role unspecified role prey prey 20 unspecified role unspecified role prey prey 8 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 14 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 18 unspecified role unspecified role prey prey association association Fig 1A, 1B, Supp. Table 1 aicda-exos3 5 9 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey association association Fig. 2A aicda-exos3-1 1 6 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 10 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey association association Fig. 2B anti-CD40, IL-4, and TGF-beta aicda-exosc3 3 13 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait 8 unspecified role unspecified role prey prey association association Fig 1A, 1B, Supp. Table 1 exosc1-exosc9 2 13 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 19 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig. 2C exosc2-aicda 2 14 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey association association Fig. 2C exosc5-aicda 2 11 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 17 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig. 2C exosc4-aicda 2 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 18 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig. 2C exosc3-aicda-2 2 13 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey association association Fig. 2C exosc6-aicda 2 8 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 11 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey association association Fig. 2C exosc7-aicda 2 11 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 12 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig. 2C exosc8-aicda 2 20 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey association association Fig. 2C exosc10-aicda 2 11 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 11 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig. 2C exosc9-aicda-1 2 11 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey association association Fig. 2C dis3-exosc10 2 13 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined association association Fig. 2C