UniProt UniProt http://www.uniprot.org A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. FEBS J. (1742-464X) 2006 mimix curation Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr 21-Dec-2011: Contacted by JYOTI. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr Accepted 2011-NOV-14 by JYOTI 21-Dec-2011: Contacted by JYOTI. FEBS J. (1742-464X) 2006 mimix curation A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. FEBS J. (1742-464X) 2006 mimix curation Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr 21-Dec-2011: Contacted by JYOTI. yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr Accepted 2011-NOV-14 by JYOTI 21-Dec-2011: Contacted by JYOTI. FEBS J. (1742-464X) 2006 mimix curation A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. FEBS J. (1742-464X) 2006 mimix curation Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr 21-Dec-2011: Contacted by JYOTI. human-daoy Homo sapiens DAOY cerebellar medulloblastoma cell line daoy DAOY cerebellar medulloblastoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr Accepted 2011-NOV-14 by JYOTI FEBS J. (1742-464X) 2006 mimix curation A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. FEBS J. (1742-464X) 2006 mimix curation Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr 21-Dec-2011: Contacted by JYOTI. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr Accepted 2011-NOV-14 by JYOTI 21-Dec-2011: Contacted by JYOTI. FEBS J. (1742-464X) 2006 mimix curation A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. FEBS J. (1742-464X) 2006 mimix curation Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr 21-Dec-2011: Contacted by JYOTI. rabit-rk13 rk13 cell line originating from rabbit kidney epithelial cells rk13 RK13 cell line produced from rabbit kidney epithelial cells 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Stankovic-Valentin N., Verger A., Deltour-Balerdi S., Quinlan K.G., Crossley M., Leprince D. created human-daoy as biosource Origin of FLAG-HIC1 according pmid 12052894; however, isoform identity cannot be established. Origin of all transfected CtBP1 and CtBP2 constructs as mouse as indicated in the paper for some experiments. dominique.leprince@ibl.fr Accepted 2011-NOV-14 by JYOTI 21-Dec-2011: Contacted by JYOTI. FEBS J. (1742-464X) 2006 mimix curation ctbp1_human C-terminal-binding protein 1 CTBP1 CTBP protein protein human Homo sapiens Human MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL DIP protein Q13363 original sequence version: 176 F071DD30B385603F ctbp1_mouse C-terminal-binding protein 1 Ctbp1 protein protein mouse Mus musculus Mouse MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYSRYPPGVVSVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHTSDQL DIP protein O88712 original sequence version: 122 DIP protein O88712 original sequence version: 125 2105CC8D69D915F4 hic1_human Hypermethylated in cancer 1 protein HIC1 ZBTB29 Zinc finger and BTB domain-containing protein 29 protein protein human Homo sapiens Human MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT 6DDD0F49C4E490D3 ctbp2_mouse C-terminal-binding protein 2 Ctbp2 protein protein mouse Mus musculus Mouse MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ 5A81B9D75A9E493B hic1-ctbp1-4 3 8 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association 2A and B hic1-ctbp1-7 1 8 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association 2C hic1-ctbp1-9 4 7 unspecified role unspecified role prey prey 8 unspecified role unspecified role bait bait Q14526:p.Leu244Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain L A Wed May 02 14:42:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu244ala' Tue Jun 30 19:39:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu244Ala' physical association physical association 1D and 4B hic1-ctbp2-2 2 9 unspecified role unspecified role prey prey P56546:p.Ala58Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain A E Wed May 02 17:51:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala58glu' Tue Jun 30 18:41:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala58Glu' P56546:p.Val72Arg mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain V R Wed May 02 18:04:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val72arg' Tue Jun 30 18:17:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val72Arg' 8 unspecified role unspecified role bait bait physical association physical association 3A hic1-ctbp2-3 1 8 unspecified role unspecified role bait bait Q14526:p.Leu244Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain L A Wed May 02 15:54:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu244ala' Tue Jun 30 17:42:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu244Ala' 9 unspecified role unspecified role prey prey P56546:p.Ala58Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain A E Wed May 02 15:18:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ala58glu' Tue Jun 30 16:43:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala58Glu' P56546:p.Val72Arg mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain V R Wed May 02 18:31:48 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'val72arg' Tue Jun 30 19:04:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Val72Arg' physical association physical association 2C , 3B and 4C hic1-ctbp1-8 5 7 unspecified role unspecified role prey prey 8 unspecified role unspecified role bait bait Q14526:p.Leu244Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain L A Wed May 02 14:29:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu244ala' Tue Jun 30 17:55:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu244Ala' physical association physical association 4A