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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
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      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
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        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Activation-modulated association of 14-3-3 proteins with Cbl in T cells.</fullName>
        </names>
        <bibref>
          <xref>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Activation-modulated association of 14-3-3 proteins with Cbl in T cells.</attribute>
            <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1996</attribute>
            <attribute name="author-list" nameAc="MI:0636">Liu YC., Elly C., Yoshida H., Bonnefoy-Berard N., Altman A.</attribute>
            <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
            <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-3">
            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>coip</shortLabel>
            <fullName>coimmunoprecipitation</fullName>
            <alias type="go synonym" typeAc="MI:0303">co-immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">CoIp</alias>
            <alias type="go synonym" typeAc="MI:0303">immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">co-immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">CoIp</alias>
            <alias type="synonym" typeAc="MI:1041">immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">coip</alias>
          </names>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Liu YC., Elly C., Yoshida H., Bonnefoy-Berard N., Altman A.</attribute>
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          <attribute name="publication year" nameAc="MI:0886">1996</attribute>
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          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>1433t_human</shortLabel>
          <fullName>14-3-3 protein theta</fullName>
          <alias type="gene name" typeAc="MI:0301">YWHAQ</alias>
          <alias type="gene name synonym" typeAc="MI:0302">14-3-3 protein tau</alias>
          <alias type="gene name synonym" typeAc="MI:0302">14-3-3 protein T-cell</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein HS1</alias>
        </names>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
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        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
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        </organism>
        <sequence>MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P27348 original sequence version: 164</attribute>
          <attribute name="remark-internal">DIP protein P27348 original sequence version: 173</attribute>
          <attribute name="crc64">175534325E9E37C4</attribute>
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      </interactor>
      <interactor id="3">
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          <shortLabel>cbl_human</shortLabel>
          <fullName>E3 ubiquitin-protein ligase CBL</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Signal transduction protein CBL</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Proto-oncogene c-Cbl</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Casitas B-lineage lymphoma proto-oncogene</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RING finger protein 55</alias>
          <alias type="gene name" typeAc="MI:0301">CBL</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CBL2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RNF55</alias>
          <alias type="gene name synonym" typeAc="MI:0302">RING-type E3 ubiquitin transferase CBL</alias>
        </names>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3PLF" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A49" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A4B" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A4C" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GPL" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HKW" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HKX" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HKY" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HKZ" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HL0" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5J3X" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5O76" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6O02" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6O03" version="SP_242"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XAR" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1059683" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1236382" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1295596" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1433559" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-182971" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2173789" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5637810" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5654726" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5654727" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5654732" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5654733" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6807004" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8849469" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8856825" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8856828" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8875360" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912631" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9706369" version="SP_242"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9706377" version="SP_242"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 173</attribute>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 128</attribute>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 145</attribute>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 150</attribute>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 191</attribute>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 91</attribute>
          <attribute name="remark-internal">DIP protein P22681 original sequence version: 139</attribute>
          <attribute name="crc64">1AA6BF67377322CA</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>cbl-ywhaq-5</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005023" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8682982" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">CBL_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005027" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P22681" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">1433T_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005024" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P27348" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">domino</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>