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    <source releaseDate="2022-02-04">
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        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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      <experimentDescription id="1">
        <names>
          <fullName>Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.</attribute>
            <attribute name="journal" nameAc="MI:0885">Biochemistry (0006-2960)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2003</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="-3">
            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
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            <shortLabel>biochemical</shortLabel>
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            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
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          <attribute name="author-list" nameAc="MI:0636">Obsil T., Ghirlando R., Anderson DE., Hickman AB., Dyda F.</attribute>
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          <attribute name="publication year" nameAc="MI:0886">2003</attribute>
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      <interactor id="2">
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          <shortLabel>foxo4_human</shortLabel>
          <fullName>Forkhead box protein O4</fullName>
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          <alias type="gene name synonym" typeAc="MI:0302">AFX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">AFX1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MLLT7</alias>
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            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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        </interactorType>
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            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
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        </organism>
        <sequence>MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP</sequence>
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          <attribute name="crc64">0C71C8E2167CEE68</attribute>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3NKX" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3RDH" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BG6" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4FJ3" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4HKC" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IHL" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4N7G" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4N7Y" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4N84" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4WRQ" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ZDR" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5D2D" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5D3F" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EWZ" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EXA" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JM4" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M35" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M36" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M37" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NAS" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5ULO" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5WXN" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5XY9" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6EF5" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6EJL" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6EWW" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6F08" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6F09" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FN9" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5J31" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FNA" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FNB" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FNC" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6Q0K" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6RLZ" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U2H" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XAG" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6YMO" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6YO8" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZFD" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZFG" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7D8H" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7D8P" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7D9V" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111447" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1445148" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3769402" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-392517" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-430116" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450604" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-512988" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5625740" version="SP_200"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6YOS" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5628897" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75035" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013700" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9604323" version="SP_200"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9614399" version="SP_200"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129171.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129172.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129173.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001129174.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003397.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_663723.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005251118.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005251120.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016869299.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016869300.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-563N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P63104 original sequence version: 144</attribute>
          <attribute name="crc64">D464DF2286BBFE60</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>foxo4-ywhaz</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006595" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7079237" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">1433Z_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006596" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P63104" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">FOXO4_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006599" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P98177" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">domino</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
      <interaction id="7">
        <names>
          <shortLabel>foxo4-ywhaz-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006602" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7079250" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="8">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">1433Z_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006603" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P63104" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="9">
            <names>
              <alias type="author assigned name" typeAc="MI:0345">FOXO4_HUMAN</alias>
            </names>
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006606" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P98177" refType="original identifier" refTypeAc="MI:0869"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">domino</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>