MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism. Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism. EMBO J. (0261-4189) 2008 imex curation Lee DC., Zheng J., She YM., Jia Z. 2009-01-08 Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Lee DC., Zheng J., She YM., Jia Z. EMBO J. (0261-4189) 2008 2009-01-08 Only protein-protein interactions imex curation etk_ecoli Tyrosine-protein kinase etk yccC etk b0981 JW0964 protein protein ecoli Escherichia coli (strain K12) MTTKNMNTPPGSTQENEIDLLRLVGELWDHRKFIISVTALFTLIAVAYSLLSTPIYQADTLVQVEQKQGNAILSGLSDMIPNSSPESAPEIQLLQSRMILGKTIAELNLRDIVEQKYFPIVGRGWARLTKEKPGELAISWMHIPQLNGQDQQLTLTVGENGHYTLEGEEFTVNGMVGQRLEKDGVALTIADIKAKPGTQFVLSQRTELEAINALQETFTVSERSKESGMLELTMTGDDPQLITRILNSIANNYLQQNIARQAAQDSQSLEFLQRQLPEVRSELDQAEEKLNVYRQQRDSVDLNLEAKAVLEQIVNVDNQLNELTFREAEISQLYKKDHPTYRALLEKRQTLEQERKRLNKRVSAMPSTQQEVLRLSRDVEAGRAVYLQLLNRQQELSISKSSAIGNVRIIDPAVTQPQPVKPKKALNVVLGFILGLFISVGAVLARAMLRRGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEKE DIP protein P38134 original sequence version: 91 DIP protein P38134 original sequence version: null BAA060F59680DA22 etk 1 etk 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6743715: original sequence: 451-726 : RGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEK P38134:p.Tyr574Phe mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F Tue Jul 12 10:21:46 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation disrupting' Wed May 02 19:57:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr574phe' Tue Jun 30 19:13:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr574Phe' range MINT-6743676: original sequence: 574-574 : LFIDADLRRGYSHNLFTVSN phosphorylation phosphorylation reaction phosphorylation true t1 mint etk-1 1 etk 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6743712: original sequence: 451-726 : RGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEK P38134:p.Tyr574Asn mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y N Tue Jul 12 10:22:04 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation disrupting' Wed May 02 18:46:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr574asn' Tue Jun 30 17:52:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr574Asn' range MINT-6743682: original sequence: 574-574 : LFIDADLRRGYSHNLFTVSN phosphorylation phosphorylation reaction phosphorylation true t1 mint etk-1 1 etk 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified P38134:p.Arg614Ala mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A Tue Jul 12 10:21:58 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation disrupting' Wed May 02 16:40:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg614ala' Tue Jun 30 18:08:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg614Ala' range MINT-6743691: original sequence: 614-614 : FGKGGFDVITRGQVPPNPSE binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6743709: original sequence: 451-726 : RGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEK phosphorylation phosphorylation reaction phosphorylation true t1 mint etk-1 1 etk 2 predetermined predetermined participant predetermined predetermined predetermined participant predetermined self self neutral component neutral component purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-6743706: original sequence: 451-726 : RGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEK P38134:p.Arg614Lys mutation disrupting interaction mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R K Tue Jul 12 10:58:00 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'mutation disrupting' Wed May 02 15:32:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg614lys' Tue Jun 30 19:42:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg614Lys' range MINT-6743700: original sequence: 614-614 : FGKGGFDVITRGQVPPNPSE phosphorylation phosphorylation reaction phosphorylation true t1 mint