MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J. (0261-4189) 2006 imex curation Sahlgren CM., Pallari HM., He T., Chou YH., Goldman RD., Eriksson JE. 2009-01-08 Only protein-protein interactions rat-st15a Rattus norvegicus st15a st15a anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Sahlgren CM., Pallari HM., He T., Chou YH., Goldman RD., Eriksson JE. EMBO J. (0261-4189) 2006 2009-01-08 Only protein-protein interactions imex curation A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J. (0261-4189) 2006 imex curation Sahlgren CM., Pallari HM., He T., Chou YH., Goldman RD., Eriksson JE. 2009-01-08 Only protein-protein interactions rat-st15a Rattus norvegicus st15a st15a imaging technique imaging technique microscopy experimental particp experimental participant identification experimental particp Sahlgren CM., Pallari HM., He T., Chou YH., Goldman RD., Eriksson JE. EMBO J. (0261-4189) 2006 2009-01-08 Only protein-protein interactions imex curation A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J. (0261-4189) 2006 imex curation Sahlgren CM., Pallari HM., He T., Chou YH., Goldman RD., Eriksson JE. 2009-01-08 Only protein-protein interactions rat-st15a Rattus norvegicus st15a st15a anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Sahlgren CM., Pallari HM., He T., Chou YH., Goldman RD., Eriksson JE. EMBO J. (0261-4189) 2006 2009-01-08 Only protein-protein interactions imex curation cdk5_rat Cyclin-dependent-like kinase 5 Cdk5 Cell division protein kinase 5 Tau protein kinase II catalytic subunit Serine/threonine-protein kinase PSSALRE Cdkn5 protein protein rat Rattus norvegicus (Rat) Rat MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP DIP protein Q03114 original sequence version: 60 4CBFF80794F931DF ubiq_rat Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb protein protein rat Rattus norvegicus (Rat) Rat MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair mint C42A35397FFD9B52 nest_rat Nestin Nes protein protein rat Rattus norvegicus (Rat) Rat MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVVRPSKEGNLESWTAFKEESQHPLGFPGAEDQMLERLVEKEDQSFPRSPEEEDQEACRPLQKENQEPLGYEEAEGQILERLIEKESQESLRSPEEEDQEAGRSLQKGNQEPLGYEEAEGQILERLIEKESQESLRSAEEEDQEACRSLQKENQEPLGYEEAEDQILERLIEKESQESLRSPEEEDQEAGRSLQKENQEPLGYEEAEDQMLERLIEKESQESLKSPEENQRIGKPLERENQKSLRYLEENQETFVPLESRNQRPLRSLEVEEEEQRIVKPLEKVSQDSLGSLAEENVQPLRYLEEDNCINKSLLEDKTHKSLGSLEDRNGDSIIIPQESETQVSLRPPEEEDQRIVNHLEKESQEFSRSSEEEERVMERSLEGENHESLSSVEKEDQMVESQLEKESQDSGKSLEDESQETFGPLEKENAESLRSLAGQDQEEQKLEQETQQTLRAVGNEQMAVSPPEKVDPELPKPLGNDQEIARSLGKENQESLVSLKEKGIETVKSLETEIIEPLETAEEDLERRKSIDTQEPLWSTEVARETVEPPEDEPPGSLGSVDENRETLTSLEKESQELSSLGKWNVETRVEDSQQCLQVEEGLQEEQHQESLREVKQELPSSGNQQRWEDVVEGKAVGQEAPLATTGVGTEDKAELHLRGQGGEEEAAAEGELLQDIVGEAWSLGSSEPKEQRVPAEALDNLEGGALEVPVAQSMPEVTERDEDRAQAGEQDSIEVTLGLEAARTGLELEQEVVGLEDPRHFAREEAIPPSLGEESVKAKIAQGLEGPGKEPKEAGALDSGILELPKTSSEALECQGHEESESMEGWEEEEASLETSDHEGSDAPQPRPPETEEDEGAQAALTAPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGSEALERVENEPEFGLGEIPEGLQDWEEGREESEADDLGETLPDSTPLGLYLRSPASPKWDLAGEQRLSPQGDAGKEDWGPAVPAAQGLSGPPEEEEEQGHGSDLSSEEFEDLGTEASLLPGVPKEVADHVGQVPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEGAESGAQWWGSGASGGGCKVQDIAQRGDPVQESVGVSGLWDDGLRGAAANVPALEMVSQDSAEPSGSEESESASLEGEEGQVTDHLDAPQEVTSMVPGVGDAFDIGGQSPNLDSEQVNGKMENGLEQAEGQVVLDGDEDQELLLQGQEVGALKVPLVASPVHLGPSQPLKFTLSGVDGDSWSSGED 03AE6B616A1A7623 cd5r1_rat Cyclin-dependent kinase 5 activator 1 Cdk5r1 Cdk5r Cyclin-dependent kinase 5 regulatory subunit 1 TPKII regulatory subunit protein protein rat Rattus norvegicus (Rat) Rat MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKAQPNSSYQSNIAHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAITSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR DIP protein P61810 original sequence version: 31 165AA0747410B0C0 cdk5-nes 3 4 polyclonal western polyclonal antibody western blot polyclonal western predetermined predetermined participant predetermined unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 6 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-3376430: original sequence: 1-640 : MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVV gfp tagged gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Stoichiometry: 1.0 physical association physical association F5D EMBO-Journal homomint mint cdk5r1-nes 3 7 western blot western blot Immuno blot Immuno blot predetermined predetermined participant predetermined unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 6 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell gfp tagged gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-3376448: original sequence: 1-640 : MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVV Stoichiometry: 1.0 physical association physical association F8C F7C EMBO-Journal homomint mint cdk5r1-cdk5-4 3 4 western blot western blot Immuno blot Immuno blot predetermined predetermined participant predetermined unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 7 western blot western blot Immuno blot Immuno blot predetermined predetermined participant predetermined unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association F7C EMBO-Journal homomint mint rps27a-cdk5r1 1 5 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell ha tagged ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Stoichiometry: 1.0 7 western blot western blot Immuno blot Immuno blot predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell Stoichiometry: 1.0 physical association physical association F9A EMBO-Journal mint cdk5r1-nes-1 2 7 experimental particp experimental participant identification experimental particp predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell Stoichiometry: 1.0 6 experimental particp experimental participant identification experimental particp predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell gfp tagged gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain range MINT-3376544: original sequence: 1-640 : MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVV Stoichiometry: 1.0 colocalization colocalization F7E EMBO-Journal homomint mint