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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
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      </bibref>
      <xref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="16614222" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1993070" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-20095" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis.</attribute>
            <attribute name="journal" nameAc="MI:0885">Science (0036-8075)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2006</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Mishra G., Zhang W., Deng F., Zhao J., Wang X.</attribute>
            <attribute name="exp-modification" nameAc="MI:0627">Galactosidase activity of yeast grown on Galactose/CM-Ura-His-Trp +Xgal  was assayed and activity was calculated and expressed through the formula: 1000 OD420 nm -1.75 OD550 nm/ total volume *OD600 nm.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">wangxue@umsl.edu</attribute>
            <attribute name="author-announcement">11-OCT-2006: Contacted by JYOTI.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="16614222" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-20095" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="4932">
            <names>
              <shortLabel>yeasx</shortLabel>
              <fullName>Saccharomyces cerevisiae (Baker's yeast)</fullName>
              <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>2 hybrid</shortLabel>
            <fullName>two hybrid</fullName>
            <alias type="go synonym" typeAc="MI:0303">2H</alias>
            <alias type="go synonym" typeAc="MI:0303">2h</alias>
            <alias type="go synonym" typeAc="MI:0303">Gal4 transcription regeneration</alias>
            <alias type="go synonym" typeAc="MI:0303">two-hybrid</alias>
            <alias type="go synonym" typeAc="MI:0303">yeast two hybrid</alias>
            <alias type="go synonym" typeAc="MI:0303">2-hybrid</alias>
            <alias type="go synonym" typeAc="MI:0303">classical two hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">classical two hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">2H</alias>
            <alias type="synonym" typeAc="MI:1041">two-hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">2-hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">Gal4 transcription regeneration</alias>
            <alias type="synonym" typeAc="MI:1041">2h</alias>
            <alias type="synonym" typeAc="MI:1041">yeast two hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">Y2H</alias>
            <alias type="synonym" typeAc="MI:1041">Y-2H</alias>
            <alias type="synonym" typeAc="MI:1041">2 hybrid</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0018" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-94" refType="identity" refTypeAc="MI:0356"/>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Mishra G., Zhang W., Deng F., Zhao J., Wang X.</attribute>
          <attribute name="exp-modification" nameAc="MI:0627">Galactosidase activity of yeast grown on Galactose/CM-Ura-His-Trp +Xgal  was assayed and activity was calculated and expressed through the formula: 1000 OD420 nm -1.75 OD550 nm/ total volume *OD600 nm.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">wangxue@umsl.edu</attribute>
          <attribute name="accepted">Accepted 2006-SEP-26 by JYOTI.</attribute>
          <attribute name="author-announcement">11-OCT-2006: Contacted by JYOTI.</attribute>
          <attribute name="journal" nameAc="MI:0885">Science (0036-8075)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2006</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>plda1_arath</shortLabel>
          <fullName>Phospholipase D alpha 1</fullName>
          <alias type="gene name" typeAc="MI:0301">PLDALPHA1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PLD1</alias>
          <alias type="locus name" typeAc="MI:0305">At3g15730</alias>
          <alias type="orf name" typeAc="MI:0306">MSJ11.13</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Choline phosphatase 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Phosphatidylcholine-hydrolyzing phospholipase D 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PLDalpha</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q38882" version="SP_70" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT3G15730.1" version="SP_172" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q944M4" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9LW06" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q0WV84" version="SP_134" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010119" version="SP_172"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046470" version="SP_172"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046686" version="SP_172"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070290" version="SP_172"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001736"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024632"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011402"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035892"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KZ8"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KZ9"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="3702">
          <names>
            <shortLabel>arath</shortLabel>
            <fullName>Arabidopsis thaliana (Mouse-ear cress)</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse-ear cress</alias>
          </names>
        </organism>
        <sequence>MAQHLLHGTLHATIYEVDALHGGGVRQGFLGKILANVEETIGVGKGETQLYATIDLQKARVGRTRKIKNEPKNPKWYESFHIYCAHLASDIIFTVKDDNPIGATLIGRAYIPVDQVINGEEVDQWVEILDNDRNPIQGGSKIHVKLQYFHVEEDRNWNMGIKSAKFPGVPYTFFSQRQGCKVSLYQDAHIPDNFVPRIPLAGGKNYEPQRCWEDIFDAISNAKHLIYITGWSVYAEIALVRDSRRPKPGGDVTIGELLKKKASEGVRVLLLVWDDRTSVDVLKKDGLMATHDEETENFFRGSDVHCILCPRNPDDGGSIVQSLQISTMFTHHQKIVVVDSEMPSRGGSEMRRIVSFVGGIDLCDGRYDTPFHSLFRTLDTVHHDDFHQPNFTGAAITKGGPREPWHDIHSRLEGPIAWDVMYNFEQRWSKQGGKDILVKLRDLSDIIITPSPVMFQEDHDVWNVQLFRSIDGGAAAGFPESPEAAAEAGLVSGKDNIIDRSIQDAYIHAIRRAKDFIYVENQYFLGSSFAWAADGITPEDINALHLIPKELSLKIVSKIEKGEKFRVYVVVPMWPEGLPESGSVQAILDWQRRTMEMMYKDVIQALRAQGLEEDPRNYLTFFCLGNREVKKDGEYEPAEKPDPDTDYMRAQEARRFMIYVHTKMMIVDDEYIIIGSANINQRSMDGARDSEIAMGGYQPHHLSHRQPARGQIHGFRMSLWYEHLGMLDETFLDPSSLECIEKVNRISDKYWDFYSSESLEHDLPGHLLRYPIGVASEGDITELPGFEFFPDTKARILGTKSDYLPPILTT</sequence>
        <attributeList>
          <attribute name="crc64">87A8692E43BD73CE</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>xlg3_arath</shortLabel>
          <fullName>Extra-large guanine nucleotide-binding protein 3</fullName>
          <alias type="gene name" typeAc="MI:0301">XLG3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Extra-large GTP-binding protein 3</alias>
          <alias type="orf name" typeAc="MI:0306">F5M6.7</alias>
          <alias type="orf name" typeAc="MI:0306">T12O21.16</alias>
          <alias type="locus name" typeAc="MI:0305">At1g31930</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9C516" version="TrEMBL_36" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.1" version="SP_142" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.2" version="SP_142" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.3" version="SP_142" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.4" version="SP_142" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.5" version="SP_142" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.6" version="SP_142" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="ensemblplants" id="AT1G31930.1" version="SP_142" refType="transcript"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.2" version="SP_142" refType="transcript"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.3" version="SP_142" refType="transcript"/>
          <secondaryRef db="ensemblplants" id="AT1G31930.4" version="SP_142" refType="transcript"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007188" version="SP_142"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009617" version="SP_142"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009723" version="SP_142"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031683" version="SP_142"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" version="SP_142"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_849737.1"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011025"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR027417"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001319126.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001320661.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001320662.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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        </interactorType>
        <organism ncbiTaxId="3702">
          <names>
            <shortLabel>arath</shortLabel>
            <fullName>Arabidopsis thaliana (Mouse-ear cress)</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse-ear cress</alias>
          </names>
        </organism>
        <sequence>MEKKDEGESWKEMVRKMLPPGAPLPEDPSEFDYSIALEYTGPPPVHDIPRVSPVDVNPRVNNPIPLPVSRIAGGVTSSSGGSPASSESVVSVLHNNPESSSGSASVSPVSGHRQNGNQVRRPVVKFKPVDDHDRIEGREAAEEEDNNVEAETERERKVHECTASTKRRKKKKKSECYRCGKAKWENKETCIVCDEKYCGNCVLRAMGSMPEGRKCVSCIGQAIDESKRSKLGKHSRVLSRLLSPLEVKQIMKAEKECTANQLRPEQLIVNGYPLKPEEMADLLNCLLPPQKLKPGRYWYDKESGLWGKEGEKPDRVISSNLNFTGKLSPDASNGNTEVYINGREITKLELRILKLANVQCPRDTHFWVYDDGRYEEEGQNNIRGNIWEKASTRFMCALFSLPVPQGQPRGTVQPSSNYATVPNYIEHKKIQKLLLLGIEGSGTSTIFKQAKFLYGNKFSVEELQDIKLMVQSNMYRYLSILLDGRERFEEEALSHTRGLNAVEGDSGGEEANDEGTVTTPQSVYTLNPRLKHFSDWLLDIIATGDLDAFFPAATREYAPLVEEVWKDPAIQATYRRKDELHFLPDVAEYFLSRAMEVSSNEYEPSERDIVYAEGVTQGNGLAFMEFSLSDHSPMSESYPENPDALSSPQPKYQLIRVNAKGMNDSCKWVEMFEDVRAVIFCISLSDYDQINITPESSGTVQYQNKMIQSKELFESMVKHPCFKDTPFILILNKYDQFEEKLNRAPLTSCDWFSDFCPVRTNNNVQSLAYQAYFYVAMKFKLLYFSITGQKLFVWQARARDRANVDEGFKYVREVLKWDEEKEESYLNGGGEDSFYSTDMSSSPYRPEE</sequence>
        <attributeList>
          <attribute name="crc64">A275FF1061405F8A</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-20095-1">
        <names>
          <shortLabel>pld1-at1g31930</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-962307" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-20095-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="7">
                <names>
                  <shortLabel>Q38882:p.Glu563Ala</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-962314" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>mutation decreasing</shortLabel>
                    <fullName>mutation decreasing interaction</fullName>
                    <alias type="go synonym" typeAc="MI:0303">hotspot</alias>
                    <alias type="synonym" typeAc="MI:1041">hotspot</alias>
                    <alias type="synonym" typeAc="MI:1041">mutation decreasing</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456519" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="563"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="563"/>
                    <resultingSequence>
                      <originalSequence>E</originalSequence>
                      <newSequence>A</newSequence>
                    </resultingSequence>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">Wed May 02 18:25:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu563ala'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 18:27:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu563Ala'</attribute>
                </attributeList>
              </feature>
              <feature id="8">
                <names>
                  <shortLabel>Q38882:p.Lys564Ala</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-962334" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>mutation decreasing</shortLabel>
                    <fullName>mutation decreasing interaction</fullName>
                    <alias type="go synonym" typeAc="MI:0303">hotspot</alias>
                    <alias type="synonym" typeAc="MI:1041">hotspot</alias>
                    <alias type="synonym" typeAc="MI:1041">mutation decreasing</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456519" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="564"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="564"/>
                    <resultingSequence>
                      <originalSequence>K</originalSequence>
                      <newSequence>A</newSequence>
                    </resultingSequence>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">Wed May 02 16:52:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys564ala'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 19:23:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys564Ala'</attribute>
                </attributeList>
              </feature>
              <feature id="9">
                <names>
                  <shortLabel>Q38882:p.Phe565Ala</shortLabel>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-962336" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>mutation decreasing</shortLabel>
                    <fullName>mutation decreasing interaction</fullName>
                    <alias type="go synonym" typeAc="MI:0303">hotspot</alias>
                    <alias type="synonym" typeAc="MI:1041">hotspot</alias>
                    <alias type="synonym" typeAc="MI:1041">mutation decreasing</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456519" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="565"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="565"/>
                    <resultingSequence>
                      <originalSequence>F</originalSequence>
                      <newSequence>A</newSequence>
                    </resultingSequence>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">Wed May 02 20:08:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe565ala'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 19:44:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe565Ala'</attribute>
                </attributeList>
              </feature>
            </featureList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Figure S2A</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>