IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU. Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU. Structure (0969-2126) 2001 imex curation Wang J., Song JJ., Seong IS., Franklin MC., Kamtekar S., Eom SH., Chung CH. This paper remodeled all the then up-to-date structures for the HslU-HslV complex. Some PDB structures do not provide a model containing both subunits in one complex. R values are not curated because the original R values don't apply to new models and the re-calculated models haven't got complete sets of associated R values given in the publication. wang@mail.csb.yale.edu 11-Jun-2014: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Wang J., Song JJ., Seong IS., Franklin MC., Kamtekar S., Eom SH., Chung CH. PDBe - Data obtained from the Protein Data Bank Europe This paper remodeled all the then up-to-date structures for the HslU-HslV complex. Some PDB structures do not provide a model containing both subunits in one complex. R values are not curated because the original R values don't apply to new models and the re-calculated models haven't got complete sets of associated R values given in the publication. wang@mail.csb.yale.edu Structure (0969-2126) 2001 imex curation atp ATP Adenosine 5'-triphosphate Adenosine triphosphate ADENOSINE-5'-TRIPHOSPHATE Adephos Adetol Adynol Atipi ATP Atriphos Cardenosine Fosfobion Glucobasin H4atp Myotriphos Triadenyl Triphosphaden adenosine 5'-(tetrahydrogen triphosphate) small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) hslv_haein ATP-dependent protease subunit HslV hslV HI_0496 protein protein haein Haemophilus influenzae MTTIVSVRRNGQVVVGGDGQVSLGNTVMKGNARKVRRLYNGKVLAGFAGGTADAFTLFELFERKLEMHQGHLLKSAVELAKDWRTDRALRKLEAMLIVADEKESLIITGIGDVVQPEEDQILAIGSGGNYALSAARALVENTELSAHEIVEKSLRIAGDICVFTNTNFTIEELPN CEA1C77B7AB2724C dadp dADP 2'-deoxyadenosine 5'-diphosphate 2'-Deoxyadenosine 5'-diphosphate 2'-DEOXYADENOSINE-5'-DIPHOSPHATE dADP deoxyadenosine diphosphate 2'-deoxyadenosine 5'-(trihydrogen diphosphate) small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) DAEAPNUQQAICNR-RRKCRQDMSA-N DAEAPNUQQAICNR-RRKCRQDMSA-N hslu_ecoli ATP-dependent protease ATPase subunit HslU hslU htpI b3931 JW3902 Unfoldase HslU Heat shock protein HslU protein protein ecoli Escherichia coli (strain K12) MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRFIL DIP protein P0A6H5 original sequence version: 98 DIP protein P0A6H5 original sequence version: 97 DIP protein P0A6H5 original sequence version: 96 D2188639EA9AEF4C hslv_ecoli ATP-dependent protease subunit HslV hslV htpO b3932 yiiC Heat shock protein HslV JW3903 protein protein ecoli Escherichia coli (strain K12) MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA DIP protein P0A7B8 original sequence version: 99 DIP protein P0A7B8 original sequence version: 97 DIP protein P0A7B8 original sequence version: 96 3B35E01F51486965 hslu_haein ATP-dependent protease ATPase subunit HslU hslU Unfoldase HslU HI_0497 protein protein haein Haemophilus influenzae MSEMTPREIVSELDQHIIGQADAKRAVAIALRNRWRRMQLQEPLRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDSAMKLVRQQEIAKNRARAEDVAEERILDALLPPAKNQWGEVENHDSHSSTRQAFRKKLREGQLDDKEIEIDVSAGVSMGVEIMAPPGMEEMTNQLQSLFQNLGSDKTKKRKMKIKDALKALIDDEAAKLINPEELKQKAIDAVEQNGIVFIDEIDKICKKGEYSGADVSREGVQRDLLPLVEGSTVSTKHGMVKTDHILFIASGAFQVARPSDLIPELQGRLPIRVELTALSAADFERILTEPHASLTEQYKALMATEGVNIAFTTDAVKKIAEAAFRVNEKTENIGARRLHTVMERLMDKISFSASDMNGQTVNIDAAYVADALGEVVENEDLSRFIL C346EA478E4094CE hslu-hslv-adp-1 1 4 cofactor cofactor coenzyme neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 5 enzyme enzyme neutral component neutral component ecoli Escherichia coli (strain K12) 6 enzyme enzyme neutral component neutral component ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig.s 1, 2a, 4, Table 1 hslu-adp-1 1 5 enzyme enzyme neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 4 cofactor cofactor coenzyme neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Fig.s 1, 2a, 4, Table 1 hslu-adp-2 1 4 cofactor cofactor coenzyme neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 5 enzyme enzyme neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig.s 1, 2a, 3, Table 1 hslu-adp-3 1 4 cofactor cofactor coenzyme neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 7 enzyme enzyme neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain haein Haemophilus influenzae direct interaction direct interaction Table 1 hslu-hslv-atp 1 3 enzyme enzyme neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain haein Haemophilus influenzae 7 enzyme enzyme neutral component neutral component region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain haein Haemophilus influenzae 2 cofactor cofactor coenzyme neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Fig.s 2, 5b, Table 1 Remodeling of 1g3i excluded 6 of the original 12 HslU subunits.