IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J. Biol. Chem. (0021-9258) 2004 Schneider D., Engelman DM. Interactions were quantified by measuring LacZ repression and assessed as strong or weak interaction. GALLEX: homo-association were detected by using the GALLEX system in which each chimeric protein has a MPB fusion in the n-terminus and in c-terminus a LexA DB binding op+ upstream to lacZ reporter gene. If two TM interacts, the dimeric LexA can bind the op+/op+ promoter/operator region repressing the activity of the reporter gene. fig 2, fig 5 donals.engelman@yale.edu ecoli Escherichia coli (strain K12) gallex lex-a dimerization assay gallex predetermined predetermined participant predetermined Schneider D., Engelman DM. Interactions were quantified by measuring LacZ repression and assessed as strong or weak interaction. GALLEX: homo-association were detected by using the GALLEX system in which each chimeric protein has a MPB fusion in the n-terminus and in c-terminus a LexA DB binding op+ upstream to lacZ reporter gene. If two TM interacts, the dimeric LexA can bind the op+/op+ promoter/operator region repressing the activity of the reporter gene. fig 2, fig 5 donals.engelman@yale.edu Annotation to indicate that this entry has been checked and accepted by a senior curator. J. Biol. Chem. (0021-9258) 2004 Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J. Biol. Chem. (0021-9258) 2004 Schneider D., Engelman DM. Interactions were quantified by measuring LacZ repression and assessed as strong or weak interaction. GALLEX: homo-association were detected by using the GALLEX system in which each chimeric protein has a MPB fusion in the n-terminus and in c-terminus a LexA DB binding op+ upstream to lacZ reporter gene. If two TM interacts, the dimeric LexA can bind the op+/op+ promoter/operator region repressing the activity of the reporter gene. fig 2, fig 5 donals.engelman@yale.edu ecoli Escherichia coli (strain K12) gallex lex-a dimerization assay gallex predetermined predetermined participant predetermined Schneider D., Engelman DM. Interactions were quantified by measuring LacZ repression and assessed as strong or weak interaction. GALLEX: homo-association were detected by using the GALLEX system in which each chimeric protein has a MPB fusion in the n-terminus and in c-terminus a LexA DB binding op+ upstream to lacZ reporter gene. If two TM interacts, the dimeric LexA can bind the op+/op+ promoter/operator region repressing the activity of the reporter gene. fig 2, fig 5 donals.engelman@yale.edu Annotation to indicate that this entry has been checked and accepted by a senior curator. J. Biol. Chem. (0021-9258) 2004 ita4_human Integrin alpha-4 Integrin alpha-IV VLA-4 subunit alpha CD49 antigen-like family member D ITGA4 CD49D protein protein human Homo sapiens Human MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD DIP protein P13612 original sequence version: 131 DIP protein P13612-1 original sequence version: 171 DIP protein P13612 original sequence version: 138 73EC1204DE78CD35 itb1_human Integrin beta-1 Fibronectin receptor subunit beta VLA-4 subunit beta ITGB1 FNRB MDF2 MSK12 Glycoprotein IIa protein protein human Homo sapiens Human MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK DIP protein P05556 original sequence version: 139 DIP protein P05556-1 original sequence version: 143 DIP protein P05556 original sequence version: 154 DIP protein P05556 original sequence version: 167 DE35979C1625578C ita2_human Integrin alpha-2 Platelet membrane glycoprotein Ia Collagen receptor VLA-2 subunit alpha CD49 antigen-like family member B ITGA2 CD49B protein protein human Homo sapiens Human MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKKGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS DIP protein P17301 original sequence version: 108 DIP protein P17301 original sequence version: 186 7E1B7ED968A94070 glpa_human Glycophorin-A PAS-2 Sialoglycoprotein alpha MN sialoglycoprotein GYPA GPA protein protein human Homo sapiens Human MYGKIIFVLLLSEIVSISASSTTGVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ 48A5450E22FA99C9 itb3_human Integrin beta-3 Platelet membrane glycoprotein IIIa ITGB3 GP3A protein protein human Homo sapiens Human MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT DIP protein P05106 original sequence version: 202 DIP protein P05106-1 original sequence version: 158 DIP protein P05106-1 original sequence version: 164 DIP protein P05106 original sequence version: 200 DIP protein P05106-1 original sequence version: 213 DIP protein P05106-1 original sequence version: 175 DIP protein P05106-1 original sequence version: 192 DIP protein P05106-1 original sequence version: 171 F246623608E05F9E itb7_human Integrin beta-7 Gut homing receptor beta subunit ITGB7 protein protein human Homo sapiens Human MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKSAITTTINPRFQEADSPTL CBE275E0E9992385 ita2b_human Integrin alpha-IIb Platelet membrane glycoprotein IIb GPalpha IIb ITGA2B GP2B ITGAB protein protein human Homo sapiens Human MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE 063EE298E026F116 itgb7-itgb7-1 1 8 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P26010:p.Gly734Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 16:23:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly734ile' Tue Jun 30 17:39:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly734Ile' P26010:p.Gly730Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 18:23:38 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly730ile' Tue Jun 30 16:14:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly730Ile' 8 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P26010:p.Gly734Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 18:34:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly734ile' Tue Jun 30 16:26:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly734Ile' P26010:p.Gly730Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 19:26:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly730ile' Tue Jun 30 19:26:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly730Ile' physical association physical association author score author-based confidence author score strong interaction itga2-itga2-1 1 5 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 5 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association weak interaction gypa-gypa-2 1 6 unspecified role unspecified role prey prey gly83ile sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 6 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P02724:p.Gly102Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 15:19:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly102ile' Tue Jun 30 20:10:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly102Ile' physical association physical association author score author-based confidence author score strong interaction itga2b-itga2b-6 1 9 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 9 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score weak interaction itga4-itga4-1 1 3 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P13612:p.Gly988Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 16:27:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly988ile' Tue Jun 30 20:21:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly988Ile' P13612:p.Ser984Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain S I Wed May 02 17:56:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser984ile' Tue Jun 30 17:47:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser984Ile' 3 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P13612:p.Gly988Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 14:49:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly988ile' Tue Jun 30 17:23:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly988Ile' P13612:p.Ser984Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain S I Wed May 02 19:54:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser984ile' Tue Jun 30 20:12:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser984Ile' physical association physical association author score author-based confidence author score weak interaction itgb1-itgb1-1 1 4 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 4 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association weak interaction itgb3-itgb3-3 1 7 unspecified role unspecified role bait bait transmembrane region tag tag certain certain sequence position certain certain certain sequence position certain 7 unspecified role unspecified role prey prey transmembrane region tag tag certain certain sequence position certain certain certain sequence position certain physical association physical association weak interaction itga2-itga2-2 2 5 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 5 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association strong interaction itga2b-itga2b-7 2 9 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 9 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score weak interaction itga4-itga4-2 2 3 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 3 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score weak interaction itgb1-itgb1-2 2 4 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 4 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association weak interaction itgb3-itgb3-4 2 7 unspecified role unspecified role bait bait mbp tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range lexa db 148 tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range transmembrane region tag tag certain certain sequence position certain certain certain sequence position certain 7 unspecified role unspecified role prey prey transmembrane region tag tag certain certain sequence position certain certain certain sequence position certain mbp tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range lexa db tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association weak interaction itgb7-itgb7-2 2 8 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score strong interaction itga2-itgb1-1 2 5 unspecified role unspecified role bait bait mbp tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain lexa db 148 tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 4 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain lexa db tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range mbp tag tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association weak interaction itga2b-itgb3-1 2 9 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 7 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score weak interaction itga4-itgb1-1 2 3 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 4 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score weak interaction itga4-itgb7-2 2 8 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P26010:p.Gly730Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 14:45:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly730ile' Tue Jun 30 17:35:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly730Ile' P26010:p.Gly734Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 17:35:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly734ile' Tue Jun 30 15:36:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly734Ile' 3 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P13612:p.Ser984Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain S I Wed May 02 15:39:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser984ile' Tue Jun 30 17:52:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser984Ile' physical association physical association author score author-based confidence author score strong interaction itgb1-itga2-1 2 4 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 5 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association strong interaction itgb1-itga4-1 2 3 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 4 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association weak interaction itgb3-itga2b-1 2 9 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 7 unspecified role unspecified role bait bait transmembrane region tag tag certain certain sequence position certain certain certain sequence position certain physical association physical association weak interaction itgb7-itga4-1 2 3 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association author score author-based confidence author score strong interaction gypa-gypa-4 2 6 unspecified role unspecified role prey prey transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain gly102ile sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain G I 6 unspecified role unspecified role bait bait transmembrane region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P02724:p.Gly102Ile mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain G I Wed May 02 17:42:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly102ile' Tue Jun 30 17:58:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly102Ile' 141 138 physical association physical association author score author-based confidence author score strong interaction