IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. J. Mol. Biol. (0022-2836) 2002 Raijmakers R., Egberts WV., van Venrooij WJ., Pruijn GJ. g.pruijn@ncmls.kun.nl chlae-cos_1 Chlorocebus aethiops COS-1 cells Grivet cos_1 CV-1 Simian cells (cercopithecus aethiops) transformed by SV40 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Raijmakers R., Egberts WV., van Venrooij WJ., Pruijn GJ. g.pruijn@ncmls.kun.nl Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01). J. Mol. Biol. (0022-2836) 2002 exos4_human Exosome complex component RRP41 EXOSC4 RRP41 SKI6 Ribosomal RNA-processing protein 41 Exosome component 4 p12A protein protein human Homo sapiens Human MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD DIP protein Q9NPD3 original sequence version: 133 7A24E97897DAF313 mtmr3_human Myotubularin-related protein 3 MTMR3 FYVE domain-containing dual specificity protein phosphatase 1 Zinc finger FYVE domain-containing protein 10 KIAA0371 ZFYVE10 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Phosphatidylinositol-3-phosphate phosphatase protein protein human Homo sapiens Human MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN FE6F4B165074D5F8 exos7_human Exosome complex component RRP42 KIAA0116 RRP42 EXOSC7 Ribosomal RNA-processing protein 42 Exosome component 7 p8 protein protein human Homo sapiens Human MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG DIP protein Q15024 original sequence version: 123 DIP protein Q15024 original sequence version: 138 A674F745CEC61BBB exos8_human Exosome complex component RRP43 OIP2 RRP43 EXOSC8 Ribosomal RNA-processing protein 43 Exosome component 8 p9 Opa-interacting protein 2 protein protein human Homo sapiens Human MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK DIP protein Q96B26 original sequence version: 125 FC8F5BAE74A1FF55 exos1_human Exosome complex component CSL4 CSL4 EXOSC1 CGI-108 Exosome component 1 protein protein human Homo sapiens Human MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT DIP protein Q9Y3B2 original sequence version: 130 E9C3B0A66F911195 exos5_human Exosome complex component RRP46 EXOSC5 CML28 RRP46 Ribosomal RNA-processing protein 46 Exosome component 5 p12B Chronic myelogenous leukemia tumor antigen 28 protein protein human Homo sapiens Human MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS DIP protein Q9NQT4 original sequence version: 123 DIP protein Q9NQT4 original sequence version: 66 DIP protein Q9NQT4 original sequence version: 112 DIP protein Q9NQT4 original sequence version: 129 DIP protein Q9NQT4 original sequence version: 105 C3C1FCB39D85B1EE exos3_human Exosome complex component RRP40 EXOSC3 RRP40 CGI-102 Ribosomal RNA-processing protein 40 Exosome component 3 p10 protein protein human Homo sapiens Human MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES DIP protein Q9NQT5 original sequence version: 130 DIP protein Q9NQT5 original sequence version: 72 DIP protein Q9NQT5 original sequence version: 117 DIP protein Q9NQT5 original sequence version: 136 264322144A199166 exos2_human Exosome complex component RRP4 EXOSC2 RRP4 Ribosomal RNA-processing protein 4 Exosome component 2 protein protein human Homo sapiens Human MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG DIP protein Q13868 original sequence version: 143 882033F50791643F rrp4-rrp41-1 1 9 unspecified role unspecified role bait bait 2 unspecified role unspecified role prey prey physical association physical association rrp4-rrp41-2 1 2 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey physical association physical association rrp4-rrp42-1 1 9 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association rrp4-rrp42-2 1 4 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey physical association physical association rrp41-rrp42-1 1 2 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association Arbitary assigment made of bait/roles since not defined by author - only that interaction seen in one direction only. rrp40-rrp46-1 1 8 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association Arbitary assigment made of bait/roles since not defined by author - only that interaction seen in one direction only. rrp42-csl4-1 1 4 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association rrp42-csl4-2 1 6 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association rrp46-csl4-1 1 7 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association rrp46-csl4-2 1 6 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association rrp46-oip2-1 1 7 unspecified role unspecified role bait bait 5 unspecified role unspecified role prey prey physical association physical association rrp46-op2-2 1 5 unspecified role unspecified role bait bait 7 unspecified role unspecified role prey prey physical association physical association rrp42-mtr3-1 1 3 unspecified role unspecified role prey prey 4 unspecified role unspecified role bait bait physical association physical association rrp42-mtr3-2 1 3 unspecified role unspecified role bait bait 4 unspecified role unspecified role prey prey physical association physical association csl4-mtr3-1 1 6 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey physical association physical association csl4-mtr3-2 1 3 unspecified role unspecified role bait bait 6 unspecified role unspecified role prey prey physical association physical association oip2-mtr3-1 1 5 unspecified role unspecified role bait bait 3 unspecified role unspecified role prey prey physical association physical association oip2-mtr3-2 1 3 unspecified role unspecified role bait bait 5 unspecified role unspecified role prey prey physical association physical association