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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Structure of the TPR domain of p67phox in complex with Rac.GTP.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="11090627" refType="primary-reference" refTypeAc="MI:0358"/>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Structure of the TPR domain of p67phox in complex with Rac.GTP.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Cell (1097-2765)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2000</attribute>
            <attribute name="author-list" nameAc="MI:0636">Lapouge K., Smith SJ., Walker PA., Gamblin SJ., Smerdon SJ., Rittinger K.</attribute>
            <attribute name="uniprot-dr-export">no</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>itc</shortLabel>
            <fullName>isothermal titration calorimetry</fullName>
            <alias type="go synonym" typeAc="MI:0303">ITC</alias>
            <alias type="synonym" typeAc="MI:1041">ITC</alias>
            <alias type="synonym" typeAc="MI:1041">itc</alias>
          </names>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Lapouge K., Smith SJ., Walker PA., Gamblin SJ., Smerdon SJ., Rittinger K.</attribute>
          <attribute name="uniprot-dr-export">no</attribute>
          <attribute name="accepted"/>
          <attribute name="journal" nameAc="MI:0885">Mol. Cell (1097-2765)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2000</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>ncf2_human</shortLabel>
          <fullName>Neutrophil cytosol factor 2</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">NOXA2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">P67PHOX</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Neutrophil NADPH oxidase factor 2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NADPH oxidase activator 2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">67 kDa neutrophil oxidase factor</alias>
          <alias type="gene name synonym" typeAc="MI:0302">p67-phox</alias>
          <alias type="gene name" typeAc="MI:0301">NCF2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P19878" version="SP_91" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-76N"/>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P19878 original sequence version: 148</attribute>
          <attribute name="crc64">EC136766E1915376</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>cdc42_human</shortLabel>
          <fullName>Cell division control protein 42 homolog</fullName>
          <alias type="gene name" typeAc="MI:0301">CDC42</alias>
          <alias type="gene name synonym" typeAc="MI:0302">G25K GTP-binding protein</alias>
        </names>
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          <participant id="6">
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                    <shortLabel>binding region</shortLabel>
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                <featureRangeList>
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                    <begin position="1"/>
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                    </endStatus>
                    <end position="203"/>
                  </featureRange>
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              </feature>
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                  <shortLabel>ecoli</shortLabel>
                  <fullName>Escherichia coli (strain K12)</fullName>
                </names>
              </hostOrganism>
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            <fullName>physical association</fullName>
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        </interactionType>
        <negative>true</negative>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">Cdc42 is GMPNP-bound</attribute>
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  </entry>
</entrySet>