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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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        <names>
          <fullName>Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.</fullName>
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            <attribute name="publication year" nameAc="MI:0886">2000</attribute>
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            <names>
              <shortLabel>in vivo</shortLabel>
              <fullName>in vivo</fullName>
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          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
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            <shortLabel>ms of complexes</shortLabel>
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            <fullName>Homo sapiens</fullName>
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        <sequence>MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN</sequence>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D6I" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JKY" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KFP" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KG6" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KL4" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6LP2" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6P5B" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6S53" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-168927" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2871837" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-445989" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450302" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450321" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607764" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693565" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693571" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693607" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5696395" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69473" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8866654" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-937039" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-937041" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9646399" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-975110" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-975144" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983168" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ULH" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UMP" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UMS" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7BBD" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7BBF" version="SP_198"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7BXG" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169408" version="SP_198"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-168638" version="SP_198"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P61088 original sequence version: 137</attribute>
          <attribute name="remark-internal">DIP protein P61088 original sequence version: 105</attribute>
          <attribute name="remark-internal">DIP protein P61088 original sequence version: 60</attribute>
          <attribute name="remark-internal">DIP protein P61088 original sequence version: 64</attribute>
          <attribute name="remark-internal">DIP protein P61088 original sequence version: 85</attribute>
          <attribute name="crc64">FACD84D883D77407</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>ube2n-ube2v1-3</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-50197" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7427166" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-433279" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>2</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>fingerprinting</shortLabel>
                  <fullName>peptide massfingerprinting</fullName>
                  <alias type="synonym" typeAc="MI:1041">fingerprinting</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0082" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-70" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="10967324" refType="primary-reference" refTypeAc="MI:0358"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="11752590" refType="primary-reference" refTypeAc="MI:0358"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="11805826" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-433274" refType="identity" refTypeAc="MI:0356"/>
            </xref>
            <interactorRef>3</interactorRef>
            <participantIdentificationMethodList>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>fingerprinting</shortLabel>
                  <fullName>peptide massfingerprinting</fullName>
                  <alias type="synonym" typeAc="MI:1041">fingerprinting</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0082" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-70" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="10967324" refType="primary-reference" refTypeAc="MI:0358"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="11752590" refType="primary-reference" refTypeAc="MI:0358"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="11805826" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
              <participantIdentificationMethod>
                <names>
                  <shortLabel>predetermined</shortLabel>
                  <fullName>predetermined participant</fullName>
                  <alias type="synonym" typeAc="MI:1041">predetermined</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </participantIdentificationMethod>
            </participantIdentificationMethodList>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <experimentalPreparationList>
              <experimentalPreparation>
                <names>
                  <shortLabel>physiological level</shortLabel>
                  <fullName>physiological level</fullName>
                  <alias type="go synonym" typeAc="MI:0303">endogenous level</alias>
                  <alias type="go synonym" typeAc="MI:0303">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous</alias>
                  <alias type="synonym" typeAc="MI:1041">endogenous level</alias>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalPreparation>
            </experimentalPreparationList>
            <attributeList>
              <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
            </attributeList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">- 160.80.34.231</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>