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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
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        <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="12684875" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1992220" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Genet. Genomics (1617-4615)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2003</attribute>
            <attribute name="author-list" nameAc="MI:0636">Lu YM., Lin YR., Tsai A., Hsao YS., Li CC., Cheng MY.</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="12684875" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="4932">
            <names>
              <shortLabel>yeasx</shortLabel>
              <fullName>Saccharomyces cerevisiae (Baker's yeast)</fullName>
              <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>2 hybrid</shortLabel>
            <fullName>two hybrid</fullName>
            <alias type="go synonym" typeAc="MI:0303">2H</alias>
            <alias type="go synonym" typeAc="MI:0303">2h</alias>
            <alias type="go synonym" typeAc="MI:0303">Gal4 transcription regeneration</alias>
            <alias type="go synonym" typeAc="MI:0303">two-hybrid</alias>
            <alias type="go synonym" typeAc="MI:0303">yeast two hybrid</alias>
            <alias type="go synonym" typeAc="MI:0303">2-hybrid</alias>
            <alias type="go synonym" typeAc="MI:0303">classical two hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">classical two hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">2H</alias>
            <alias type="synonym" typeAc="MI:1041">two-hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">2-hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">Gal4 transcription regeneration</alias>
            <alias type="synonym" typeAc="MI:1041">2h</alias>
            <alias type="synonym" typeAc="MI:1041">yeast two hybrid</alias>
            <alias type="synonym" typeAc="MI:1041">Y2H</alias>
            <alias type="synonym" typeAc="MI:1041">Y-2H</alias>
            <alias type="synonym" typeAc="MI:1041">2 hybrid</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0018" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-94" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id="12634794" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="1946372" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Lu YM., Lin YR., Tsai A., Hsao YS., Li CC., Cheng MY.</attribute>
          <attribute name="accepted">Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01).</attribute>
          <attribute name="journal" nameAc="MI:0885">Mol. Genet. Genomics (1617-4615)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2003</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>htl1_yeast</shortLabel>
          <fullName>High temperature lethal protein 1</fullName>
          <alias type="locus name" typeAc="MI:0305">YCR020W-B</alias>
          <alias type="gene name" typeAc="MI:0301">HTL1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">DRT1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Chromatin structure-remodeling complex protein HTL1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9URQ5" version="SP_50" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblfungi" id="YCR020W-B" version="SP_158" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D6VR30" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8717" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006337" version="SP_158"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006338" version="SP_158"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006368" version="SP_158"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016586" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6K15" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KW3" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KW4" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KW5" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TDA" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6V8O" version="SP_158"/>
          <secondaryRef db="ensemblfungi" id="YCR020W-B" version="SP_158" refType="gene"/>
          <secondaryRef db="ensemblfungi" id="YCR020W-B_mRNA" version="SP_158" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000086" version="SP_158"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_158"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6V92" version="SP_158"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_009949.1"/>
          <secondaryRef db="sgd" dbAc="MI:0484" id="S000006439"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q9URQ5"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="559292">
          <names>
            <shortLabel>yeast</shortLabel>
            <fullName>Saccharomyces cerevisiae</fullName>
            <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
          </names>
        </organism>
        <sequence>MSQNNTISSMNPERAYNNVTLKNLTAFQLLSQRENICELLNLVESTERHNSIINPERQRMSLEEMKKMLDALKNERKK</sequence>
        <attributeList>
          <attribute name="crc64">62308D5A1F6322C7</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>rsc8_yeast</shortLabel>
          <fullName>Chromatin structure-remodeling complex protein RSC8</fullName>
          <alias type="gene name" typeAc="MI:0301">RSC8</alias>
          <alias type="locus name" typeAc="MI:0305">YFR037C</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SWH3</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Remodel the structure of chromatin complex subunit 8</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SWI3 homolog</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P43609" version="SP_73" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6B289" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D6VTS0" version="SP_102" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensemblfungi" id="YFR037C" version="SP_196" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-23005" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="sgd" dbAc="MI:0484" id="S000001933"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_116695.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-1478N"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P43609"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR041984" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043145" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6K15" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KW3" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KW4" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KW5" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TDA" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6V8O" version="SP_196"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6V92" version="SP_196"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-SCE-3214858" version="SP_196"/>
          <secondaryRef db="ensemblfungi" id="YFR037C_mRNA" version="SP_196" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="SP_196"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_196"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" version="SP_196"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006368" version="SP_196"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" version="SP_196"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016514" version="SP_196"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042393" version="SP_196"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043044" version="SP_196"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000433" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001005" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007526" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009057" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017884" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017930" version="SP_196"/>
          <secondaryRef db="ensemblfungi" id="YFR037C" version="SP_196" refType="gene"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032451" version="SP_196"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036388" version="SP_196"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="559292">
          <names>
            <shortLabel>yeast</shortLabel>
            <fullName>Saccharomyces cerevisiae</fullName>
            <alias type="synonym" typeAc="MI:1041">Baker's yeast</alias>
          </names>
        </organism>
        <sequence>MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEESATLGAEVAHKKINYEQEAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSNPDFFNDSSRFKTPKAYKDTRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKIHAFLEKWGLINYQIDPRTKPSLIGPSFTGHFQVVLDTPQGLKPFLPENVIKQEVEGGDGAEPQVKKEFPVNLTIKKNVYDSAQDFNALQDESRNSRQIHKVYICHTCGNESINVRYHNLRARDTNLCSRCFQEGHFGANFQSSDFIRLENNGNSVKKNWSDQEMLLLLEGIEMYEDQWEKIADHVGGHKRVEDCIEKFLSLPIEDNYIREVVGSTLNGKGGDSRDGSVSGSKLMECVNDAVQTLLQGDDKLGKVSDKSREISEKYIEESQAIIQELVKLTMEKLESKFTKLCDLETQLEMEKLKYVKESEKMLNDRLSLSKQILDLNKSLEELNVSKKLVLISEQVDSGIQLVEKDQEGDDEDGNTATGHGVKRVGKEGEEVGEGDSIAKLQPQVYKPWSL</sequence>
        <attributeList>
          <attribute name="crc64">D3D3120397CF0058</attribute>
          <attribute name="crc64">D3D3120397CF0058</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>htl1-rsc8-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-74072" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>