MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol. Cell. Biol. (0270-7306) 2001 Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining partial coverage rapid curation in vitro In vitro pull down pull down predetermined predetermined participant predetermined Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining Accepted 2013-AUG-29 by ORCHARD Mol. Cell. Biol. (0270-7306) 2001 partial coverage rapid curation SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol. Cell. Biol. (0270-7306) 2001 Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining partial coverage rapid curation chlae-cos_1 Chlorocebus aethiops COS-1 cells Grivet cos_1 CV-1 Simian cells (cercopithecus aethiops) transformed by SV40 anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining Accepted 2013-AUG-29 by ORCHARD Mol. Cell. Biol. (0270-7306) 2001 partial coverage rapid curation SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol. Cell. Biol. (0270-7306) 2001 Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining partial coverage rapid curation baker's yeast-l40 Saccharomyces cerevisiae l40 l40 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining Accepted 2013-AUG-29 by ORCHARD Mol. Cell. Biol. (0270-7306) 2001 partial coverage rapid curation SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol. Cell. Biol. (0270-7306) 2001 Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining partial coverage rapid curation mouse-hemopoietic Mus musculus hemopoietic hemopoietic anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang B., Lemay S., Tsai S., Veillette A. no Phosphatases text-mining Accepted 2013-AUG-29 by ORCHARD Mol. Cell. Biol. (0270-7306) 2001 partial coverage rapid curation ptn18_mouse Tyrosine-protein phosphatase non-receptor type 18 Ptpn18 Flp1 Ptpk1 Fetal liver phosphatase 1 PTP-K1 protein protein mouse Mus musculus Mouse MSRHTDLVRSFLEQLEARDYREGAILAREFSDIKARSVAWKSEGVCSTKAGSRLGNTNKNRYKDVVAYDETRVILSLLQEEGHGDYINANFIRGIDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAREQEPLKAGPFCITLTKETTLNADITLRTLQVTFQKEFRSVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQDTSPHYQNLKENCAPICKEAFSLRTSSALPATSRPPGGVLRSISVPAPPTLPMADTYAVVQKRGASAGTGPGPRAPTSTDTPIYSQVAPRAQRPVAHTEDAQGTTALRRVPADQNSSGPDAYEEVTDGAQTGGLGFNLRIGRPKGPRDPPAEWTRV mint homomint May be involved in growth and differentiation of hematopoietic cells 88AD7E73CE8136B0 csk_rat Tyrosine-protein kinase CSK Csk C-Src kinase protein protein rat Rattus norvegicus (Rat) Rat MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases mint homomint 393DC8D737DAC67A csk_mouse Tyrosine-protein kinase CSK Csk C-Src kinase Protein-tyrosine kinase MPK-2 p50CSK protein protein mouse Mus musculus Mouse MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHIKTHELHL E8D3EC9357B86277 csk-ptpn18-10 3 PTP-HSCF 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain 6 unspecified role unspecified role bait bait physical association physical association F1A homomint mint csk-ptpn18-5 1 csk 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified gst tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined PTP-HSCF 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey partially purified partially purified trap-mutant trapping mutant trap-mutant trapping mutant trap-mutant mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Cys229Ser direct interaction direct interaction F3B F3C homomint mint csk-ptpn18-6 2 PTP-HSCF 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell trap-mutant trapping mutant trap-mutant trapping mutant trap-mutant mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Cys229Ser csk 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell binding site binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain physical association physical association F2 F3A homomint mint csk-ptpn18-7 2 csk 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell PTP-HSCF 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell binding site binding region binding-associated region binding region mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain phosphorylated phosphorylated residue phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain trap-mutant trapping mutant trap-mutant trapping mutant trap-mutant mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Cys229Ser physical association physical association F4 homomint mint csk-ptpn18-8 2 csk 6 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell PTP-HSCF 5 predetermined predetermined participant predetermined predetermined predetermined participant predetermined unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell binding site binding region binding-associated region binding region mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain trap-mutant trapping mutant trap-mutant trapping mutant trap-mutant mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Cys229Ser phosphorylated phosphorylated residue phosres phosphorylated residue PhosRes Phospho Phosphorylation Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain physical association physical association F4 homomint mint csk-csk-1 4 PTP-HSCF 5 antibody detection identification by antibody antibody detection predetermined predetermined participant predetermined unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level 7 unspecified role unspecified role bait bait physical association physical association F6 homomint mint