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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
        <xref>
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        </xref>
      </bibref>
      <xref>
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      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
        <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="9878069" refType="primary-reference" refTypeAc="MI:0358"/>
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          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.</attribute>
            <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1999</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Pyronnet S., Imataka H., Gingras AC., Fukunaga R., Hunter T., Sonenberg N.</attribute>
            <attribute name="uniprot-dr-export">no</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human</shortLabel>
              <fullName>Homo sapiens</fullName>
              <alias type="synonym" typeAc="MI:1041">Human</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>coip</shortLabel>
            <fullName>coimmunoprecipitation</fullName>
            <alias type="go synonym" typeAc="MI:0303">co-immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">CoIp</alias>
            <alias type="go synonym" typeAc="MI:0303">immunoprecipitation</alias>
            <alias type="go synonym" typeAc="MI:0303">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">co-immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">CoIp</alias>
            <alias type="synonym" typeAc="MI:1041">immunoprecipitation</alias>
            <alias type="synonym" typeAc="MI:1041">Co-IP</alias>
            <alias type="synonym" typeAc="MI:1041">coip</alias>
          </names>
          <xref>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>polyclonal western</shortLabel>
            <fullName>polyclonal antibody western blot</fullName>
            <alias type="synonym" typeAc="MI:1041">polyclonal western</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0086" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Pyronnet S., Imataka H., Gingras AC., Fukunaga R., Hunter T., Sonenberg N.</attribute>
          <attribute name="uniprot-dr-export">no</attribute>
          <attribute name="accepted">Accepted 2010-JAN-10 by SKERRIEN (applied to all records created before 2005-Sep-01).</attribute>
          <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1999</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>mknk1_human</shortLabel>
          <fullName>MAP kinase-interacting serine/threonine-protein kinase 1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">MAP kinase signal-integrating kinase 1</alias>
          <alias type="gene name" typeAc="MI:0301">MKNK1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MNK1</alias>
        </names>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
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        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL</sequence>
        <attributeList>
          <attribute name="crc64">CAE225C35DCB2B43</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>if4e_human</shortLabel>
          <fullName>Eukaryotic translation initiation factor 4E</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">mRNA cap-binding protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">eIF-4F 25 kDa subunit</alias>
          <alias type="gene name" typeAc="MI:0301">EIF4E</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EIF4EL1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EIF4F</alias>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001317946.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-22N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 164</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 127</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 126</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 135</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 151</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 155</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 160</attribute>
          <attribute name="remark-internal">DIP protein P06730-1 original sequence version: 187</attribute>
          <attribute name="remark-internal">DIP protein P06730 original sequence version: 146</attribute>
          <attribute name="crc64">B869B8DE615E699D</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>if4g1_human</shortLabel>
          <fullName>Eukaryotic translation initiation factor 4 gamma 1</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">p220</alias>
          <alias type="gene name" typeAc="MI:0301">EIF4G1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EIF4G</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EIF4GI</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EIF4F</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q04637" version="SP_82" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O43177" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O95066" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5HYG0" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6ZN21" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8N102" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-11020102" refType="intact-secondary"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DNT4" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DNT5" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DNT2" version="SP_151" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9PFM1" version="SP_151" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="G5E9S1" version="SP_151" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-28974642" refType="intact-secondary"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000316879" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-73711" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000342981"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000343450"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000316879"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000350481"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000317600"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000352767"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000338020"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000382330"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000371767"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000392537"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000376320"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000414031"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000391935"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000424196"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000416255"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000434061"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000411826"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_886553.3"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_937884.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_937885.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004944.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-1161N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000114867" version="SP_231" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000346169" version="SP_231" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001662" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002191" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003729" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003743" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005844" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006412" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006413" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006446" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008135" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008190" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010494" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010507" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010801" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010942" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030307" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031369" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031669" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032270" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032502" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034645" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0036493" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045666" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060090" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060964" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0080135" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097009" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1900087" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905537" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905606" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905612" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905618" version="SP_231"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905696" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003307" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003890" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003891" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016021" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016024" version="SP_231"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037584" version="SP_231"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q04637" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LJ2" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UG3" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W97" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4AZA" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4F02" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EHC" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EI3" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EIR" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5T46" version="SP_231"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZMW" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169408" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-156827" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-166208" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-429947" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450408" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72649" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72662" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72702" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72706" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9010553" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-975956" version="SP_231"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-975957" version="SP_231"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 68</attribute>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 166</attribute>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 160</attribute>
          <attribute name="remark-internal">DIP protein Q04637-1 original sequence version: 94</attribute>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 115</attribute>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 119</attribute>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 146</attribute>
          <attribute name="remark-internal">DIP protein Q04637-1 original sequence version: 148</attribute>
          <attribute name="remark-internal">DIP protein Q04637 original sequence version: 150</attribute>
          <attribute name="crc64">324088B60863DA34</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5" imexId="IM-13580-1">
        <names>
          <shortLabel>eif4e-mnk1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-73920" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">The interaction between eif4e and mnk1 is indirect. mnk1 interacts directly with eif4e interacting protein eif4g, rather than with eif4e.</attribute>
        </attributeList>
      </interaction>
      <interaction id="8" imexId="IM-13580-2">
        <names>
          <shortLabel>mnk1-eif4e</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-73979" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="10">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="comment" nameAc="MI:0612">The interaction between mnk1 and eif4e is indirect. mnk1 interacts directly with eif4e interacting protein eif4g, rather than with eif4e.</attribute>
        </attributeList>
      </interaction>
      <interaction id="11" imexId="IM-13580-3">
        <names>
          <shortLabel>eif4g-mnk1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-73986" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-3" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="12">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="13">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
      <interaction id="14" imexId="IM-13580-4">
        <names>
          <shortLabel>mnk1-eif4g</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-74022" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-4" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="15">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="16">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>