<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>HPIDb</shortLabel>
        <fullName>Host Pathogen Interaction database</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1335" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6598961" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.agbase.msstate.edu/hpi/main.html</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Binding of hepatitis C virus to CD81.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="9794763" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-9119587" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-25851" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Binding of hepatitis C virus to CD81.</attribute>
            <attribute name="journal" nameAc="MI:0885">Science (0036-8075)</attribute>
            <attribute name="publication year" nameAc="MI:0886">1998</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Pileri P., Uematsu Y., Campagnoli S., Galli G., Falugi F., Petracca R., Weiner A.J., Houghton M., Rosa D., Grandi G., Abrignani S.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="contact-email" nameAc="MI:0634">abrignani@iris02.biocine.it</attribute>
            <attribute name="author-announcement">10-Mar-2014: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="9794763" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25851" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>far western blotting</shortLabel>
            <fullName>far western blotting</fullName>
            <alias type="go synonym" typeAc="MI:0303">Affinity blotting</alias>
            <alias type="synonym" typeAc="MI:1041">Affinity blotting</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0047" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1099" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Pileri P., Uematsu Y., Campagnoli S., Galli G., Falugi F., Petracca R., Weiner A.J., Houghton M., Rosa D., Grandi G., Abrignani S.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="contact-email" nameAc="MI:0634">abrignani@iris02.biocine.it</attribute>
          <attribute name="accepted">Accepted 2014-FEB-13 by ORCHARD</attribute>
          <attribute name="journal" nameAc="MI:0885">Science (0036-8075)</attribute>
          <attribute name="publication year" nameAc="MI:0886">1998</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>p27958-pro_0000037570</shortLabel>
          <fullName>Envelope glycoprotein E2</fullName>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P27958-PRO_0000037570" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6904269" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-706378" refType="chain-parent" refTypeAc="MI:0951"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="63746">
          <names>
            <shortLabel>HCV77</shortLabel>
            <fullName>Hepatitis C virus genotype 1a (isolate H77)</fullName>
          </names>
        </organism>
        <sequence>ETHVTGGNAGRTTAGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFNSSGCPERLASCRRLTDFAQGWGPISYANGSGLDERPYCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCVIGGVGNNTLLCPTDCFRKYPEATYSRCGSGPRITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTLPALSTGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADARVCSCLWMMLLISQAEA</sequence>
        <attributeList>
          <attribute name="chain-seq-start">384</attribute>
          <attribute name="chain-seq-end">746</attribute>
          <attribute name="crc64">9243E2103B6CCA2D</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>cd81_human</shortLabel>
          <fullName>CD81 antigen</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">26 kDa cell surface protein TAPA-1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Target of the antiproliferative antibody 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Tetraspanin-28</alias>
          <alias type="gene name" typeAc="MI:0301">CD81</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TAPA1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TSPAN28</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P60033" version="SP_45" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000263645" version="SP_173" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P18582" version="SP_45" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5U0J6" version="SP_45" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-712921" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000110651" version="SP_173" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000263645" version="SP_173" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000187" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001618" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001771" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001772" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002455" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002863" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008104" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009925" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0014905" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015485" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016323" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0023026" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030890" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031623" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031647" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031982" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034238" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035783" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042289" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043128" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046718" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046813" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050861" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050862" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0061462" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070863" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071404" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072659" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0072675" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097197" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1903911" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904352" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905521" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1905676" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990459" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000553" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000563" version="SP_173"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001190" version="SP_173"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000301" version="SP_173"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008952" version="SP_173"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018499" version="SP_173"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018503" version="SP_173"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P60033" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1G8Q" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1IV5" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AVZ" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3X0E" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5DFV" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5DFW" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M2C" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M33" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M3D" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M3T" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M4R" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5TCX" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6EJG" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6EJM" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6EK2" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U9S" version="SP_173"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7JIC" version="SP_173"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-198933" version="SP_173"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-977606" version="SP_173"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004347.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001284578.1"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY</sequence>
        <attributeList>
          <attribute name="crc64">EB9BD7671AC91B4A</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-25851-1">
        <names>
          <shortLabel>p27958_pro-cd81-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-9119606" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25851-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="83333">
                <names>
                  <shortLabel>ecoli</shortLabel>
                  <fullName>Escherichia coli (strain K12)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">Fig. 2B</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>