IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science (New York, N.Y.) 2020 imex curation Dai W., Zhang B., Su H., Li J., Zhao Y., Xie X., Jin Z., Liu F., Li C., Li Y., Bai F., Wang H., Cheng X., Cen X., Hu S., Yang X., Wang J., Liu X., Xiao G., Jiang H., Rao Z., Zhang LK., Xu Y., Yang H., Liu H. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus From Pablo's list:DOI:10.1101/2020.03.25.996348 hliu@simm.ac.cn, yanght@shanghaitech.edu.cn, zhangleike@wh.iov.cn, ycxu@simm.ac.cn Only protein-protein interactions imex curation in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Dai W. Virus - Publications including interactions involving viral proteins From Pablo's list:DOI:10.1101/2020.03.25.996348 hliu@simm.ac.cn, yanght@shanghaitech.edu.cn, zhangleike@wh.iov.cn, ycxu@simm.ac.cn Accepted 2020-JUN-12 AT 17:27 BST AT 17:27 BST by PPORRAS Science 2020 Only protein-protein interactions imex curation imex curation Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science (New York, N.Y.) 2020 imex curation Dai W., Zhang B., Su H., Li J., Zhao Y., Xie X., Jin Z., Liu F., Li C., Li Y., Bai F., Wang H., Cheng X., Cen X., Hu S., Yang X., Wang J., Liu X., Xiao G., Jiang H., Rao Z., Zhang LK., Xu Y., Yang H., Liu H. Virus - Publications including interactions involving viral proteins Coronavirus - Interactions investigated in the context of Coronavirus From Pablo's list:DOI:10.1101/2020.03.25.996348 hliu@simm.ac.cn, yanght@shanghaitech.edu.cn, zhangleike@wh.iov.cn, ycxu@simm.ac.cn Only protein-protein interactions imex curation in vitro In vitro cleavage cleavage assay cleavage predetermined predetermined participant predetermined Dai W. Virus - Publications including interactions involving viral proteins From Pablo's list:DOI:10.1101/2020.03.25.996348 hliu@simm.ac.cn, yanght@shanghaitech.edu.cn, zhangleike@wh.iov.cn, ycxu@simm.ac.cn Accepted 2020-JUN-12 AT 17:27 BST AT 17:27 BST by PPORRAS Science 2020 Only protein-protein interactions imex curation imex curation p0dtd1-pro_0000449623 3C-like proteinase nsp5 rep ORF1ab polyprotein 1a-1b protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 3264 3569 mca-avlqsgfr-lys(dnp)-lys-nh2 MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) AVLQSGFR inhibitor 11a Inhibitor 11A small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) inhibitor 11b inhibitor 11b small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) inhibitor 11a-rep-1 1 5 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) 3 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Table S1 inhibitor 11a-rep-2 1 6 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) 3 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Table S1 mca_avlqsgfr_lys(dnp)_lys_nh2-rep-1 2 4 enzyme target enzyme target substrate substrate neutral component neutral component n-terminal fluorophore fluorophore n-term range n-terminal range n-term range n-term range n-terminal range n-term range chemical synthesis Chemical synthesis (Chemical synthesis) 3 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) cleavage cleavage reaction cleavage 2 A/B mca_avlqsgfr_lys(dnp)_lys_nh2-rep-2 2 5 inhibitor inhibitor neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 4 enzyme target enzyme target substrate substrate neutral component neutral component n-terminal fluorophore fluorophore n-term range n-terminal range n-term range n-term range n-terminal range n-term range chemical synthesis Chemical synthesis (Chemical synthesis) 3 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) cleavage cleavage reaction cleavage 2 A inhibitor 11a-mca_avlqsgfr_lys(dnp)_lys_nh2-1 2 6 inhibitor inhibitor neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) 4 enzyme target enzyme target substrate substrate neutral component neutral component n-terminal fluorophore fluorophore n-term range n-terminal range n-term range n-term range n-terminal range n-term range chemical synthesis Chemical synthesis (Chemical synthesis) 3 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) cleavage cleavage reaction cleavage 2 B