DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature 2019 imex curation Yun-Tao Liu, Jonathan Jih, Xinghong Dai, Guo-Qiang Bi & Z. Hong Zhou, Liu YT., Jih J., Dai X., Bi GQ., Zhou ZH. Virus - Publications including interactions involving viral proteins hong.zhou@ucla.edu Only protein-protein interactions imex curation chlae-vero Chlorocebus (Cercopithecus) aethiops kidney cells Grivet vero Chlorocebus (Cercopithecus) aethiops kidney cells similar to cos-7 cells but these are not trasnformed 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Yun-Tao Liu, Jonathan Jih, Xinghong Dai, Guo-Qiang Bi & Z. Hong Zhou, Liu YT., Jih J., Dai X., Bi GQ., Zhou ZH. Virus - Publications including interactions involving viral proteins hong.zhou@ucla.edu Accepted 2020-JUN-08 AT 08:22 BST AT 08:22 BST by MGT Nature 2019 imex curation d3ypi2_hhv1 Capsid vertex component 2 UL25 CVC2 HHV1gp036 hmpv205_0025 hmpv208_0025 hmpv214_0025 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MDPYCPFDALDVWEHRRFIVADSRNFITPEFPRDFWMSPVFNLPRETAAEQVVVLQAQRTAAAAALENAAMQAAELPVDIERRLRPIERNVHEIAGALEALETAAAAAEEADAARGDEPAGGGDGGAPPGLAVAEMEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGATGSSGVVFGTWYRTIQDRTITDFPLTTRSADFRDGRMSKTFMTALVLSLQSCGRLYVGQRHYSAFECAVLCLYLLYRNTHGAADDSDRAPVTFGDLLGRLPRYLACLAAVIGTEGGRPQYRYRDDKLPKTQFAAGGGRYEHGALASHIVIATLMHHGVLPAAPGDVPRDASTHVNPDGVAHHDDINRAAAAFLSRGHNLFLWEDQTLLRATANTITALGVIQRLLANGNVYADRLNNRLQLGMLIPGAVPSEAIARGASGSDSGAIKSGDNNLEALCANYVLPLYRADPAVELTQLFPGLAALCLDAQAGRPVGSTRRVVDMSSGARQAALVRLTALELINRTRTNPTPVGEVIHAHDALAIQYEQGLGLLAQQARIGLGSNTKRFSAFNVSSDYDMLYFLCLGFIPQYLSAV 1A10F6BD60620F05 h9e912_hhv1 Portal protein UL6 HHV1gp011 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MTAPRSWAPTTRARGDTEALCSPEDGWVKVHPTPGTMLFREILHGQLGYTEGQGVYNVVRSSEATTRQLQAAIFHALLNATTYRDLEADWLGHVAARGLQPQRLVRRYRNAREADIAGVAERVFDTWRNTLRTTLLDFAHGLVACFAPGGPSGPSSFPKYIDWLTCLGLVPILRKRQEGGVTQGLRAFLKQHPLTRQLATVAEAAERAGPGFFELALAFDSTRVADYDRVYIYYNHRRGDWLVRDPISGQRGECLVLWPPLWTGDRLVFDSPVQRLFPEIVACHSLREHAHVCRLRNTASVKVLLGRKSDSERGVAGAARVVNKVLGEDDETKAGSAASRLVRLIINMKGMRHVGDINDTVRAYLDEAGGHLIDAPAVDGTLPGFGKGGNSRGSAGQDQGGRAPQLRQAFRTAVVNNINGVLEGYINNLFGTIERLRETNAGLATQLQERDRELRRATAGALERQQRAADLAAESVTGGCGSRPAGADLLRADYDIIDVSKSMDDDTYVANSFQHPYIPSYAQDLERLSRLWEHELVRCFKILCHRNNQGQETSISYSSGAIAAFVAPYFESVLRAPRVGAPITGSDVILGEEELWDAVFKKTRLQTYLTDIAALFVADVQHAALPPPPSPVGADFRPGASPRGRSRSRSPGRTAPGAPDQGGGIGHRDGRRDGRR C5F9ED5BD8DDF60A f8rev0_hhv1 Capsid vertex component 1 UL17 CVC1 HHV1gp024 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MNAHLANEVQYDLGHVPGRPSSLVHVIISSECLAAAGIPLAALMRGRPGLGTAANFQVEIQTRAHATGDCTPWCTAFAAYVPADAVGELLAPVVPAHPGLLPRASSAGGLFVSLPVVCDAQGVYDPYAVAALRLAWGSGASCARVILFSYDELVPPNTRYAADSTRIMRVCRHLCRYVALLGAAAPPAAKEAAAHLSMGLGESASPRPQPLARPHAGAPADPPIVGASDPPISPEEQLTAPGGDTTAAQDVSIAQENEEILALVQRAVQDVTRRHPVRARTGRAACGVASGLRQGALVHQAVSGGAMGAADADAVLAGLEPPGGGRFVAPVPHGPGGEDILNDVLTLTPGTAKPRSLVEWLDRGWEALAGGDRPDWLWSRRSISVVLRHHYGTKQRFVVVSYENSVAWGGRRARPPLLSSALATALTEACAAERVVRPHQLSPAGQAELLLRFPALEVPLRHPRPVLPPFDIAAEVAFTARIHLACLRALGQAIRAALQGGPRISQRLRYDFGPDQRAWLGEVTRRFPILLENLMRAVEGTAPDAFFHTAYALAVLAHLGGRGGRGRRVVPLGDDLPARFADSDGHYVFDYYSTSGDTLRLNNRPIAVAMDGDVSKREQSKCRFMEAVPSTAPRRVCEQYLPGESYAYLCLGFNRRLCGIVVFPGGFAFTINIAAYLSLSDPVARAAVLRFCRKVSSGNGRSR 82A4BCCC70EF1947 i1uyk0_hhv1 Large tegument protein deneddylase UL36 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MIAGTPPHSTMERGGDRDIVVTGARNQFAPDLEPGGSVSCMRSSLSFLSLIFDVGPRDVLSAEAIEGCLVEGGEWTRATAGPGPPRMCSIVELPNFLEYPGARGGLRCVFSRVYGEVGFFGEPAAGLLETQCPAHTFFAGPWALRPLSYTLLTIGPLGMGLFRDGDTAYLFDPHGLPEGTPAFIAKVRAGDMYPYLTYYTRDRPDVRWAGAMVFFVPSGPEPAAPADLTAAALHLYGASETYMQDEAFSERRVAITHPLRGEIAGLGEPCVGVGPREGGGGPGPHPPTAAQSPPPTRARRDDRASETSRGTAGPSAKPEAKRPNRAPDDVWAVALKGTPPTDPPSADPPSAIPPPPPSAPKTPAAEAAEEDDDDMRVLEMGVVPVGRHRARYSAGLPKRRRPTWTPPSSVEDLTSGEKTKRSAPPAKTKKKSTPKGKTPVGAAVPASVPEPVLASAPPDPAGPPVAEAGEDDGPMVPASSQALEALKTRRSPEPPGADLAQLFEAHPNVAATAVKFTACSATLAREVAACSRLTISALRSPYPASPGLLELCVIFFFERVLAFLIENGARTHTQAGVAGPAAALLEFTLSMLPRKTAVGDFLASTRLSLADVAAHLPLVQHVLDENSLIGRLALAKLILVARDVIRETDAFYGELADLELQLRAAPPANLYTRLGEWLLERSQAHPDTLFAPATPTHPEPLLYRVQALAKFARGEEIRVEAEDRQMREALDALARGVDAVSQHAGPLGVMPAPAGAAPQGAPRPPPLGPEAVQVRLEEVRTQARRAIEGAVKEYFYRGAVYSAKALQASDNNDRRFHVASAAVVPVVQLLESLPVFDQHTRDIAQRAAIPAPPPIATSPTAILLRDLIQRGQTLDAPEDLAAWLSVLTDAANQGLIERKPLDELARSIRDINDQQARRSSGLAELRRFDALDAALGQQLDSDAAFVPAPGASPYPDDGGLSPEATRMAEEALRQARAMDAAKLTAELAPDARARLRERARSLEAMLEGARERAKVARDAREKFLHKLQGVLRPLPDFVGLKACPAVLATLRASLPAGWSDLPEAVRGAPPEVTAALRADMWGLLGQYRDALEHPTPDTATALSGLHPSFVVVLKNLFADAPETPFLLQFFADHAPIIAHAVSNAINAGSAAVATADPASTVDAAVRAHRVLVDAVTALGAAASDPASPLAFLAAMADSAAGYVKATRLALDARGAIAQLTTLGSAAADLVVQVRRAANQPEGEHASLIQAATRATTGARESLAGHEGRFGGLLHAEGTAGDHSPSGRALQELGKVIGATRRRADELEAAIADLREKMAAQRARSSHERWAADVEAVLDRVESGAEFDVVELRRLQALAGTHGYNPRDFRKRAEQALGTNAKAVTLALETALAFNPYTPENQRHPMLPPLAAIHRIDWSAAFGAAADTYADMFRVDTEPLARLLRLAGGLLERAQANDGFIDYHEAVLHLSEDLGGVPALRQYVPFFQKGYAEYVDIRDRLDALRADARRAIGSVALDLAAAAEEISAVRNDPAAAAELVRAGVTLPCPSEDALVACVAALERVDQSPVKDTAYADYVAFVTRQDLADTKDAVVRAKQQRAEATERVTAGLREVLAARERRAQLEAEGLANLKTLLKVVAVPATVAKTLDQARSAEEIADQVEILLDQTEKARELDVQAVAWLEHAQRTFETHPLNAASGDGPGLLTRQGARLQALFDTRRRVEALRRSLEEAEAEWDEVWGRFGRVRGGAWKSPEGFRAACEQLRALQDTTNTVSGLRAQRDYERLPAKYQGVLGAKSAERAGAVEELGGRVAQHADLSARLRDEVVPRVAWEMNFDTLGGLLAEFDAVAGDLAPWAVEEFRGARELIQRRMGLYSAYAKATGQTGAGAAAAPAPLLVDLRALDARARASAPPGQEADPQMLRRRGEAYLRVSGGPGPLVLREATSTLDRPFAPSFLVPDGTPLQYALCFPAVTDKLGALLMCPEAACIRPPLPTDTLESASTVTAMYVITVINRLQLALSDAQAANFQLFGRFVRHRQARWGASMDAAAELYVALVATTLTREFGCRWAQLEWGGDAAAPGPPLGPHSSTRHRVSFNENDVLVALVASSPEHIYTFWRLDLVRQHEYMHLTLPRAFQNAADSMLFVQRLTPHPDARIRVLPVFSTGGPPTRGLMFGTRLADWRRGKLSETDPLAPWRSVPELGTERGAALGKLSPAQALAAVSVLGRMCLPSTALAALWTCMFPDDYTEYDSFDALLTARLESGQTLSPSGGREASPPAPPNALYRPTGQHVAVPAAATHRTPAARVTAMDLVLAAVLLGAPVVVALRNTTAFSRESELELCLTLFDSRARGPDAALRDAVSSDIETWAVRLLHADLNPIENACLAAQLPRLSALIAERPLARGPPCLVLVDISMTPVAVLWENPDPPAPPDVRFVGSEATEELPFVAGGEDVLAASATDEDPFLARAILGRPFDASLLSGELFPGHPVYQRAPDDQSPSVPNPTPGPADLVGTEGSLGPGSLAPTLFTDATPGEPVPPRMWAWIHGLEELASDDSGGPAPLLAPDPLSPTADQSVPTSQCAPRPPGPAVTAREARPGVPAESTRPAPVGPRDDFRRLPSPQSSPAPPDATAPRPPASSRASAASSSGSRARRHRRARSLARATQASATTQGWRPPALPDTVAPVTDFARPPAPPKPPEPALHALVSGVPLPLGPQFAGQASPALPIDPVPPPVATGTVLPGGENRRPPLTSGPAPTPPRVPVGGPQRRLTRPAVASLSESRESLPSPWDPADPTAPVLGRNPAEPTSSSPAGPSPPPPAVQPVTPPPTSGPPPTYLTLEGGVTPGGPVSRRPTTRQPVATPTTSARPRGHLTVNRLSAPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQNGHVAPGEYPAVRFRAPQNRPSVPASASSTNPRTGSSLSGVSSWASSLALHIDATPPPVSLLQTLYVSDDEDSDTTSLFLSDSEAEALDPLPREPHSPITNEPFSALSADDSQEVTRLQFGPPPVSANAVLSRRYVQRTGRSALAVLIRACYRLQQQLQRTRRALLHHSDAVLTSLHHVRMLLG 368FE7C5557D80EA g8h8d9_hhv1 Triplex capsid protein 2 UL18 TRX2 UL18-UL20.6 HHV1gp030 hmpv207_0017 hmpv213_0017 hmpv214_0018 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MLADGFETDIAIPSGISRPDAAALQRCEGRVVFLPTIRRQLTLADVAHESFVSGGVSPDTLGLLLAYRRRFPAVITRVLPTRIVACPLDVGLTHAGTVNLRNTSPVDLCNGDPISLVPPVFEGQATDVRLDSLDLTLRFPVPLPSPLAREIVARLVARGIRDLNPSPRNPGGLPDLNVLYYNGSRLSLLADVQQLGPVNAELRSLVLNMVYSITEGTTIILTLIPRLFALSAQDGYVNALLQMQSVTREAAQLIHPEAPALMQDGERRLPLYEALVAWLTHAGQLGDTLALAPVVRVCTFDGAAVVRSGDMAPVIRYP 6D9925F5179B5B3A h9e925_hhv1 Major capsid protein UL19 MCP HHV1gp028 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MAAPNRDPPGYRYAAAMVPTGSLLSTIEVASHRRLFDFFSRVRSDANSLYDVEFDALLGSYCNTLSLVRFLELGLSVACVCTKFPELAYMNEGRVQFEVHQPLIARDGPHPIEQPTHNYMTKIIDRRALNAAFSLATEAIALLTGEALDGTGISAHRQLRAIQQLARNVQAVLGAFERGTADQMLHVLLEKAPPLALLLPMQRYLDNGRLATRVARATLVAELKRSFCETSFFLGKAGHRREAVEAWLVDLTTATQPSVAVPRLTHADTRGRPVDGVLVTTAPIKQRLLQSFLKVEDTEADVPVTYGEMVLNGANLVTALVMGKAVRSLDDVGRHLLEMQEEQLDLNRQTLDELESAPQTTRVRADLVSIGEKLIFLEALEKRIYAATNVPYPLVGAMDLTFVLPLGLFNPVMERFAAHAGDLVPAPGHPDPRAFPPRQLFFWGKDRQVLRLSLEHAIGTVCHPSLMNVDAAVGGLNRDPVEAANPYGAYVAAPAGPAADMQQLFLNAWGQRLAHGRVRWVAEGQMTPEQFMQPDNANLALELHPAFDFFVGVADVELPGGDVPPAGPGEIQATWRVVNGNLPLALCPAAFRDARGLELGVGRHAMAPATIAAVRGAFEDRNYPAVFYLLQAAIHGSEHVFCALARLVVQCITSYWNNTRCAAFVNDYSLVSYVVTYLGGDLPEECMAVYRDLVAHVEALAQLVDDFTLTGPELGGQAQAELNHLMRDPALLPPLVWDCDALMRRAALDRHRDCRVSAGGHDPVYAAACNVATADFNRNDGQLLHNTQARAADAADDRPHRGADWTVHHKIYYYVMVPAFSRGRCCTAGVRFDRVYATLQNMVVPEITPGEDCPSDPVTDPAHPLHPANLVANTVNAMFHNGRVVVDGPAMLTLQVLAHNMAERTTALLCSAAPDAGANTASTTNMRIFDGALHAGILLMAPQHLDHTIQNGDYFYPLPVHALFAGADHVANAPNFPPALRDLSRQVPLVPPALGANYFSSIRQPVVQHVRESAAGENALTYALMAGYFKISPVALHHQLKTGLHPGFGFTVVRQDRFVTENVLFSERASEAYFLGQLQVARHETGGGVNFTLTQPRGNVDLGVGYTAVVATATVRNPVTDMGNLPQNFYLGRGAPPLLDNAAAVYLRNAVVAGNRLGPAQPVPVFGCAQVPRRAGMDHGQDAVCEFIATPVSTDVNYFRRPCNPRGRAAGGVYAGDKEGDVTALMYDHGQSDPSRAFAATANPWASQRFSYGDLLYNGAYHLNGASPVLSPCFKFFTSADIAAKHRCLERLIVETGSAVSTATAASDVQFKRPPGCRELVEDPCGLFQEAYPLTCASDPALLRSARNGEAHARETHFAQYLVYDASPLKGLAL 6BFCE4405BAEB1E8 q25bw6_hhv1 Small capsomere-interacting protein UL35 SCP UL31.5-UL35 HHV1gp052 hmpv205_0036 hmpv206_0036 hmpv207_0035 hmpv208_0036 hmpv213_0033 hmpv214_0036 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MAVPQFHRPSTVTTDSVRALGMRGLVLATNNSQFIMDNNHPHPQGTQGAVREFLRGQAAALTDLGLAHANNTFTPQPMFAGDAPAAWLRPAFGLRRTYSPFVVREPSTPGTP ACC56F7EA0BA7384 q1t724_hhv1 Triplex capsid protein 1 UL38 TRX1 VP19C HHV1gp056 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 MKTNPLPATPSVWGGSTVELPPTTRDTAGQGLLRRVLRPPISRRDGPVLPRGSGPRRAASTLWLLGLDGTDAPPGALTPNDDTEQALDKILRGTMRGGAALIGSPRHHLTRQVILTDLCQPNADRAGTLLLALRHPADLPHLAHQRAPPGRQTERLGEAWGQLMEATALGSGRAESGCTRAGLVSFNFLVAACAASYDARDAADAVRAHVTANYRGTRVGARLDRFSECLRAMVHTHVFPHEVMRFFGGLVSWVTQDELASVTAVCAGPQEAAHTGHPGRPRSAVILPACAFVDLDAELGLGGPGAAFLYLVFTYRQRRDQELCCVYVIKSQLPPRGLEPALERLFGRLRITNTIHGTEDMTPPAPNRNPDFPLAGLAANPQTPRCSAGQVTNPQFADRLYRWQPDLRGRPTARTCTYAAFAELGMMPEDSPRCLHRTERFGAVSVPVVILEGVVWRPGEWRACA C17F4BDCF2597447 ul6-1 1 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified physical association physical association Extended Data Table 1 ul17-ul18-1 1 7 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 5 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 8 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 2 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 4 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 6 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 9 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified physical association physical association Extended Data Table 1