HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production. The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production. The Journal of general virology 2015 imex curation Mine J., Tamura T., Mitsuhashi K., Okamatsu M., Parchariyanon S., Pinyochon W., Ruggli N., Tratschin JD., Kida H., Sakoda Y. Virus - Publications including interactions involving viral proteins sakoda@vetmed.hokudai.ac.jp 17-Oct-2016: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Mine J., Tamura T., Mitsuhashi K., Okamatsu M., Parchariyanon S., Pinyochon W., Ruggli N., Tratschin JD., Kida H., Sakoda Y. Virus - Publications including interactions involving viral proteins sakoda@vetmed.hokudai.ac.jp Accepted 2016-OCT-06 AT 09:53 BST AT 09:53 BST by ORCHARD The Journal of general virology 2015 imex curation p19712-pro_0000038050 N-terminal protease protein protein CSFV Classical swine fever virus (strain Alfort) Hog cholera virus MELNHFELLYKTSKQKPVGVEEPVYDTAGRPLFGNPSEVHPQSTLKLPHDRGRGDIRTTLRDLPRKGDCRSGNHLGPVSGIYIKPGPVYYQDYTGPVYHRAPLEFFDEAQFCEVTKRIGRVTGSDGKLYHIYVCVDGCILLKLAKRGTPRTLKWIRNFTNCPLWVTSC 1 168 F2D196BB6A5F0F47 irf3_pig Interferon regulatory factor 3 IRF3 protein protein pig Sus scrofa (Pig) Pig MGTQKPRILPWLISQLNQGQLEGVAWLDEGHTRFRIPWKHGLRQDAQQEDFGIFQAWAEASGAYTPGKDKPDLPTWKRNFRSALNRKEALRLAEDHSKDPHDPHKIYEFVTSGVGDFPEPDTSLDLSGRYSTSDTHEDSLDKLLSGMDLASDAGPQSLTLALEQPPQLSLSPSVDAPASCPNLGVRENPLKQLLANDDEWEFQVTVFYRGCQVFQQTVCSPGGLRLVGSEAEDGTLAGQPVRLPDPAASLTDRGVADYVRRVLSCLGGGLALWRAGQWLWAQRLGHCHVYWAMGEELIPDSGHKPDGEVPKDREGGVFDLGPFIEDLIAFIEGSRRSPRYTLWFCMGQSWPQDEPWVKRLVMVKVVPMCLRALVDMARDGGASSLENTVDLHISNSHPLSLTSDQYKACLRDLVEDMDF 8B731861BE002284 a0a0a8jet1_9flav Genome polyprotein protein protein CSFV Classical swine fever virus (strain Alfort) Hog cholera virus MELNYFEFLYKTNKQKSMGVEEPVYDATGRPLFGDPSEVLPQSTLKLPHDRGRGNIKTTLNNLPRKGDCRSGNHLGPVSGIYVKPGPVFYQDYMGPVYHRAPLEFFNEAQFCDVTKRIGRVTGSDGKLYHIYVCIDGCILLKLAKRGEPRSLKWIRNFTDCPLWVTSCSDDGASGSREKKPDRINKGKLKIAPKEHEKDSRTKPPDATIVVEGVKYQVKKKGKVKGKNTQDGLYHNKNKPPESRKKLEKTLLAWAVIAIMLYQPVEAENITQWNLSDNGTNGIQHAMYLRGVSRSLYGIWPEKICKGVPTYLATDTELKEIQGMMDASEGTNYTCCKLQRHEWNKHGWCNWYNIDPWIQLMNRTQANLAEGPPAKECAVTCRYDKDADINVVTQARNRPITLTGCKKGKNFSFAGTIIEGPCNFNVSVEDILYGDHECGSLLQDTALYLVDGMTNTIENARQGAARVTSWLGRQLRIAGKRLEGRSKTWFGAYALSPYCNVTSKMGYIWYTNNCTPACLPKNTKIIGPGKFDTNAEDGKILHEMGGHLSEFLLLSLVVLSDFAPETASALYLIFHYVIPQSYEEPEGCDTNQLNLTVELRTEDVIPSSVWNVGKYVCVRPDWWPYETKVALLFEEAGQVVKLALRALRDLTRVWNSASTTAFLICLIKVLRGQIVQGVIWLLLVTGAQGRLACKEDYRYAISSTNEIGPLGARGLTTTWKEYSHDLQLNDGTVKAICVAGSFKTTVLNLVSRRYLASLHKRALPTSVTFELLFDGTNPSTEEMGDDFGFGLCPFDTSPVVKGKYNTTLLNGSAFYLVCPIGWTGVVECTAVSPTTLRTEVVKTFRREKPFPHRMDCVITTVENEDLFYCKLGGNWTCVKGEPVVYTGGQVKQCRWCGFDFNKPDGLPHYPIGKCILANETGYRIVDSTDCNRDGVVISTEGSHECLIGNTTVKVHASDGRLGPMPCRPKEIVSSAGPVRKTSCTFKYAKTLKNKYYEPRDSYFQQYMLKGEYQYWFDLDVTDRHSDYFAEFVVLVVAALLGGRYVLWLIVTYIVLTEQLAAGLPLGQGEVVLIGNLITHTDIEVVVYFLLLYMVMRDEPIKKWILLLFHAMTNNPVKTITVALLMVSGVAKGGKIDGGWQRLPETSFDIQLALTVIVVVVMLLAKRDPTTVPLVITVATLRTAKMTNGLSTDIAIATVSTALLTWTYISDYYRYKTWLQYLISTVTGIFLIRVLKGIGELDLHTPTLPSYRPLFFILVYLISTAVVTRWNLDIAGLLLQCVPTLLMVFTMWADILTLILILPTYELTKLYYLKEVKTGAERGWLWKTNFKRVNDMYEVDQAGEGVYLFPSKQKTSSITGTMLPLIKAILISCISNKWQFIYLMYLIFEVSYYLHKKIIDEIAGGTNFVSRLVAALIEANWAFDNEEVRGLKKFLLLSSRVKELVIKHKVRNEVMVHWFGDEEVYGMPKLVCLVKAATLSKNKHCILCTVCEDREWKGETCPKCGRFGPPMTCGMTLADFEEKHYKRIFFREDQSEGPVREEYAGYLQYRARGQLFLRNLPVLATKVKMLLVGNLGTEVGDLEHLGWVLRGPAVCKKVTEHEKCTTSIMDKLTAFFGVMPRGTTPRAPVRFPTSLLKIRRGLETGWAYTHQGGISSVDHVTCGKDLLVCDTMGRTRVVCQSNNKMTDESEYGVKTDSGCPEGARCYVFNPEAVNISGTKGAMVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNEDSKPTKLMSGIQTVSKSTTDLTEMVKKITTMNRGEFRQITLATGAGKTTELPRSVIEEIGRHKRVLVLIPLRAAAESVYQYMRQKHPSIAFNLRIGEMKEGDMATGITYASYGYFCQMPQPKLRAAMVEYSFIFLDEYHCATPEQLAIMGKIHRFSENLRVVAMTATPAGTVTTTGQKHPIEEFIAPEVMKGEDLGSEYLDIAGLKIPVEEMKSNMLVFVPTRNMAVETAKKLKAKGYNSGYYYSGEDPSNLRVVTSQSPYVVVATNAIESGVTLPDLDVVVDTGLKCEKRIRLSPKMPFIVTGLKRMTVTIGEQAQRRGRVGRVKPGRYYRSQETPVGSKDYHYDLLQAQRYGIEDGINITKSFREMNYDWSLYEEDSLMITQLEVLNNLLISEELPMAVKNIMARTDHPEPIQLAYNSYETQVPVLFPKIKNGEVTDSYDNYTFLNARKLGVDVPPYVYATEDEDLAVELLGLDWPDPGNHGTVEAGRALKQVVGLSTAENALLVALFGYVGYQALSKRHIPVVTDIYSIEDHRLEDTTHLQYAPNAIKTEGKETELKELAQEDVQRCVEAMTNYAREGIQFMKSQALKVIETPTYKETTDTVTDYVKKFMEALTDSKEDIMKYGLWGTHTALYKSISARLGSETAFATLVVKWLAFGGESIEDHVKQAATDLVVYYIINRPQFPGDTETQQEGRKFVASLLASALATYTYKSWNYNNLSKIVEPALATLPYAATALKLFAPTRLESVVILSTAIYKTYLSIRRGKSDGLLGVGVSATMEIMSQNPVSVGIAVMLGVGAVAAHNAIESSEQKRTLLMKVFVKNFLDQAATDELVKESPEKIIMALFEAVQTIGNPLRLVYHLYGAFYKGWEAKELAQRTAGMNLFTLIMFEAVELLGVDSEGKIRQLSSNYILELLYKFRDGIKSSVREMAISWAPAPFSCDWTPTDDRIGLPQDNFFQVETKCPCGYKMKAVKNCAGELRLLEEEGSFLCRNKFGRGSRNYRVTKYYDDNLSEIKPVIKMEGHVELYYKGATIKLDFNNSKTILATDKWEVDHSTLVRVLKRHTGAGYHGAYLGEKPNHKHLIERDCATITKDKVCFLKMKRGCAFTYDLSLHNLTRLIELVHKNNLEDKEIPAVTVTTWLAYTFVNEDIGTIKPAFGEKVTPEVQEEITLQPAVVVDATDVTVTVVGEAPTMTTGETPTAFTSSGSDPQGQQVLKLGVGEGQYPGINPQRASLHEAIQGADERPFVLILGSDKATSNRVKTAKNVKVYRGRDPLEVRDMMRRGKILVIALSKVDNXLLKFVDYKGNFLTRETLEALSLGRPKKKNITKAEAQWLLCPEDKMEELPGWFAAGEPIFLEANIKHDRYHLVGDIATIKEKAKQLGATDSTKISKEVGAKVYSMKLSNWVMQEENKQGKLTPLFEELLQQCPPGGQNKTAHMVSAYQLAQGNWMPTSCHVFMGTISARRTKTHPYEAYVKLRELVEEHKMKTLCPGSSLGKHNEWIIGKIKYQGNLRTKHMLNPGKVAEQLCREGHRHNVYNKTIGSVMTATGIRLEKLPVVRAQTDTTNFHQAIRDKIDKEENLQTPGLHKKLMEVFNALRRPELESSYDAVEWEELERGINRKGAAGFFERKNIGEILDSEKNKVEEIIDNLKKGRNIKYYETAIPKNEKRDVNDDWTAGDFVDEKKPRVIQYPEAKTRLAITKVMYKWVKQKPVVIPGYEGKTPLFQIFDKVKKEWDQFQNPVAVSFDTKAWDTQVTTKDLELIKDIQKYYFKKKWHKFIDTLTMHMTEVPVICADGEVYIRKGQRGSGQPDTSAGNSMLNVLTMVYAFCEATGVPYKSFDRVAKIHVCGDDGFLITERALGEKFASKGVQILYEAGKPQKITEGDKMKVAYQFDDIEFCSHTPIQVRWSDNTSSYMPGRNTTTILAKMATRLDSSGERGTIAYEKAVAFSFLLMYSWNPLIRRICLLVLSTELQVKPGKSTTYYYEGDPISAYKEVIGHNLFDLKRTSFEKLAKLNLSMSVLGAWTRHTS npro-irf3-5 1 2 unspecified role unspecified role bait bait dna bd dna binding domain dna binding domain tag dna binding domain undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P19712-PRO_0000038050:p.Asp136Asn mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain D N Wed May 02 15:48:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp136asn' Tue Jun 30 18:47:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp136Asn' 3 unspecified role unspecified role prey prey vp16 vp16 ad vp16 activation domain vp16 ad undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined physical association physical association 6 npro-irf3-6 1 4 unspecified role unspecified role bait bait a0a0a8jet1_9flav:p.Leu40His mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain L H Wed May 02 14:31:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu40his' Tue Jun 30 18:22:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu40His' a0a0a8jet1_9flav:p.[Ser17Pro;Asn61Lys] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain S P certain certain sequence position certain certain certain sequence position certain N K Mon Oct 03 14:50:55 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'ser17pro_asn61lys' Wed May 02 15:06:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser17pro,asn61lys' Tue Jun 30 20:19:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser17Pro;Asn61Lys]' Npro region sufficient to bind sufficient binding region sufficient to bind range range range range a0a0a8jet1_9flav:p.[Ser17Pro;Leu40His;Asn61Lys] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain L H certain certain sequence position certain certain certain sequence position certain N K certain certain sequence position certain certain certain sequence position certain S P Mon Oct 03 14:52:51 BST 2016 This feature has been corrected as a result of our quality control procedures. The original label was 'ser17pro_leu40his_asn61lys' Wed May 02 17:10:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser17pro,leu40his,asn61lys' Tue Jun 30 16:34:06 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser17Pro;Leu40His;Asn61Lys]' 3 unspecified role unspecified role prey prey physical association physical association 6