HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html Human La protein interaction with GCAC near the initiator AUG enhances hepatitis C Virus RNA replication by promoting linkage between 5' and 3' untranslated regions. Human La protein interaction with GCAC near the initiator AUG enhances hepatitis C Virus RNA replication by promoting linkage between 5' and 3' untranslated regions. J. Virol. (0022-538X) 2013 imex curation Kumar A., Ray U., Das S. Virus - Publications including interactions involving viral proteins sdas@mcbl.iisc.ernet.in 13-Jan-2014: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Kumar A., Ray U., Das S. Virus - Publications including interactions involving viral proteins sdas@mcbl.iisc.ernet.in Accepted 2013-NOV-28 by ORCHARD J. Virol. (0022-538X) 2013 imex curation la_human Lupus La protein SSB Sjoegren syndrome type B antigen La ribonucleoprotein La autoantigen protein protein human Homo sapiens Human MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ DIP protein P05455 original sequence version: 116 DIP protein P05455 original sequence version: 110 EC153C15F9187FC4 q99ib8-pro_0000045603 RNA-directed RNA polymerase protein protein hcvjf Hepatitis C virus genotype 2a (isolate JFH-1) HCV SMSYSWTGALITPCSPEEEKLPINPLSNSLLRYHNKVYCTTSKSASQRAKKVTFDRTQVLDAHYDSVLKDIKLAASKVSARLLTLEEACQLTPPHSARSKYGFGAKEVRSLSGRAVNHIKSVWKDLLEDPQTPIPTTIMAKNEVFCVDPAKGGKKPARLIVYPDLGVRVCEKMALYDITQKLPQAVMGASYGFQYSPAQRVEYLLKAWAEKKDPMGFSYDTRCFDSTVTERDIRTEESIYQACSLPEEARTAIHSLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACKAAGIVAPTMLVCGDDLVVISESQGTEEDERNLRAFTEAMTRYSAPPGDPPRPEYDLELITSCSSNVSVALGPRGRRRYYLTRDPTTPLARAAWETVRHSPINSWLGNIIQYAPTIWVRMVLMTHFFSILMVQDTLDQNLNFEMYGSVYSVNPLDLPAIIERLHGLDAFSMHTYSHHELTRVASALRKLGAPPLRVWKSRARAVRASLISRGGKAAVCGRYLFNWAVKTKLKLTPLPEARLLDLSSWFTVGAGGGDIFHSVSRARPRSLLFGLLLLFVGVGLFLLPAR 2443 3033 92FA1DE7EA9B8DBC positive- sense rna HCV JFH-1 positive- sense RNA rna ribonucleic acid RNA rna hcvjf Hepatitis C virus genotype 2a (isolate JFH-1) HCV q99ib8-pro_0000045599 Serine protease/helicase NS3 protein protein hcvjf Hepatitis C virus genotype 2a (isolate JFH-1) HCV APITAYAQQTRGLLGAIVVSMTGRDRTEQAGEVQILSTVSQSFLGTTISGVLWTVYHGAGNKTLAGLRGPVTQMYSSAEGDLVGWPSPPGTKSLEPCKCGAVDLYLVTRNADVIPARRRGDKRGALLSPRPISTLKGSSGGPVLCPRGHVVGLFRAAVCSRGVAKSIDFIPVETLDVVTRSPTFSDNSTPPAVPQTYQVGYLHAPTGSGKSTKVPVAYAAQGYKVLVLNPSVAATLGFGAYLSKAHGINPNIRTGVRTVMTGEAITYSTYGKFLADGGCASGAYDIIICDECHAVDATSILGIGTVLDQAETAGVRLTVLATATPPGSVTTPHPDIEEVGLGREGEIPFYGRAIPLSCIKGGRHLIFCHSKKKCDELAAALRGMGLNAVAYYRGLDVSIIPAQGDVVVVATDALMTGYTGDFDSVIDCNVAVTQAVDFSLDPTFTITTQTVPQDAVSRSQRRGRTGRGRQGTYRYVSTGERASGMFDSVVLCECYDAGAAWYDLTPAETTVRLRAYFNTPGLPVCQDHLEFWEAVFTGLTHIDAHFLSQTKQAGENFAYLVAYQATVCARAKAPPPSWDAMWKCLARLKPTLAGPTPLLYRLGPITNEVTLTHPGTKYIATCMQADLEVMT 1031 1661 B6CEB07928DC653D ns5b-la-1 1 NS5B 3 unspecified role unspecified role prey prey La 2 unspecified role unspecified role bait bait physical association physical association Fig. 5A Mutation in the GCAC motif (346-349) near the initiator AUG in the SLIV region of the HCV internal ribosomal entry site (IRES) decrease interaction ns5b-la-2 1 La 2 unspecified role unspecified role prey prey NS5B 3 unspecified role unspecified role bait bait physical association physical association Fig. 5B Mutation in the GCAC motif (346-349) near the initiator AUG in the SLIV region of the HCV internal ribosomal entry site (IRES) decrease interaction ns3-la-1 1 NS3 5 unspecified role unspecified role prey prey La 2 unspecified role unspecified role bait bait physical association physical association Fig. 7H Mutation in the GCAC motif (346-349) near the initiator AUG in the SLIV region of the HCV internal ribosomal entry site (IRES) decrease interaction rna-la-1 1 4 unspecified role unspecified role prey prey region mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain La 2 unspecified role unspecified role bait bait physical association physical association Fig. 3B and 5A Mutation in the GCAC motif (346-349) near the initiator AUG in the SLIV region of the HCV internal ribosomal entry site (IRES) decrease interaction