HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J. Viral Hepat. (1352-0504) 2011 imex curation Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org 02-Aug-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh-7.5 Human Huh-7.5 cells huh75 Huh-7.5 cells confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org Accepted 2013-JUN-27 by ORCHARD 02-Aug-2013: Contacted by IntAct-Help. J. Viral Hepat. (1352-0504) 2011 imex curation Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J. Viral Hepat. (1352-0504) 2011 imex curation Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org 02-Aug-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org Accepted 2013-JUN-27 by ORCHARD 02-Aug-2013: Contacted by IntAct-Help. J. Viral Hepat. (1352-0504) 2011 imex curation Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J. Viral Hepat. (1352-0504) 2011 imex curation Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org 02-Aug-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org Accepted 2013-JUN-27 by ORCHARD 02-Aug-2013: Contacted by IntAct-Help. J. Viral Hepat. (1352-0504) 2011 imex curation Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J. Viral Hepat. (1352-0504) 2011 imex curation Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org 02-Aug-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org Accepted 2013-JUN-27 by ORCHARD 02-Aug-2013: Contacted by IntAct-Help. J. Viral Hepat. (1352-0504) 2011 imex curation Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J. Viral Hepat. (1352-0504) 2011 imex curation Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org 02-Aug-2013: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-liver Homo sapiens liver liver liver confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org Accepted 2013-JUN-27 by ORCHARD 02-Aug-2013: Contacted by IntAct-Help. J. Viral Hepat. (1352-0504) 2011 imex curation q9wmx2-pro_0000037541 Core protein precursor protein protein hcvco Hepatitis C virus genotype 1b (isolate Con1) (HCV) STNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARQPEGRAWAQPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTIPASA 2 191 BF5EAC00C5E85A24 q9wmx2-pro_0000037548 Serine protease/helicase NS3 protein protein hcvco Hepatitis C virus genotype 1b (isolate Con1) (HCV) APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSSTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNAVAYYRGLDVSVIPTSGDVIVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVTTTHPITKYIMACMSADLEVVT 1027 1657 A84CEABAAB30E03E vime_human Vimentin VIM protein protein human Homo sapiens Human MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE DIP protein P08670 original sequence version: 195 DIP protein P08670 original sequence version: 209 DIP protein P08670 original sequence version: 192 DIP protein P08670 original sequence version: 175 BAB54026665B015A flna_human Filamin-A FLNA FLN FLN1 Alpha-filamin Filamin-1 Endothelial actin-binding protein Actin-binding protein 280 Non-muscle filamin protein protein human Homo sapiens Human MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP DIP protein P21333 original sequence version: 185 DIP protein P21333-1 original sequence version: 187 DIP protein P21333 original sequence version: 115 DIP protein P21333 original sequence version: 144 DIP protein P21333-1 original sequence version: 156 DIP protein P21333 original sequence version: 201 DIP protein P21333 original sequence version: 197 DIP protein P21333 original sequence version: 170 6C1A07041DF50142 q9wmx2-pro_0000037551 Non-structural protein 5A protein protein hcvco Hepatitis C virus genotype 1b (isolate Con1) (HCV) SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC 1973 2419 AC8324B2DE0F7FAE calx_human Calnexin CANX Major histocompatibility complex class I antigen-binding protein p88 p90 IP90 protein protein human Homo sapiens Human MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE DIP protein P27824 original sequence version: 177 EDE094D9B82261EE ns3-fila-3 2 NS3 7 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig. 2A fila-ns5a-3 2 Filamin-A 9 unspecified role unspecified role neutral component neutral component NS5A 10 unspecified role unspecified role neutral component neutral component colocalization colocalization 2a fila-ns5a-1 5 Filamin-A 9 unspecified role unspecified role neutral component neutral component NS5A 10 unspecified role unspecified role neutral component neutral component colocalization colocalization 2c ns3-fila-1 5 NS3 7 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization 2c core-fila-2 2 Core 6 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization S3 9-13 cell line core-vim-4 2 Core 6 unspecified role unspecified role neutral component neutral component Vimentin 8 unspecified role unspecified role neutral component neutral component colocalization colocalization S3 9-13 cell line flna-ns3-2 4 NS3 7 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma Filamin-A 9 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association 3 flna-ns5a-1 4 NS5A 10 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma Filamin-A 9 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association 3 flna-ns3-1 4 Filamin-A 9 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma NS3 7 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association 3 ns5a-flna-1 4 NS5A 10 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma Filamin-A 9 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association 3 flna-core-1 3 Filamin-A 9 unspecified role unspecified role neutral component neutral component Core 6 unspecified role unspecified role neutral component neutral component colocalization colocalization S3 CNS3 cell line core-vim-1 3 Vimentin 8 unspecified role unspecified role neutral component neutral component Core 6 unspecified role unspecified role neutral component neutral component colocalization colocalization S3 CNS3 cell line core-fila-1 1 Core 6 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization S3 and 2b CON1 cell core-vim-2 1 Vimentin 8 unspecified role unspecified role neutral component neutral component Core 6 unspecified role unspecified role neutral component neutral component colocalization colocalization S3 and 2b CON1 cell ns3-fila-2 1 NS3 7 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization 2b CON1 cell fila-ns5a-2 1 NS5A 10 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization 2b CON1 cell flna-q9wmx2_pro-2 3 NS3 7 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization Fig. 2A flna-q9wmx2_pro-1 3 NS5A 10 unspecified role unspecified role neutral component neutral component Filamin-A 9 unspecified role unspecified role neutral component neutral component colocalization colocalization 2a canx-q9wmx2_pro-2 3 NS3 7 unspecified role unspecified role neutral component neutral component Calnexin 11 unspecified role unspecified role neutral component neutral component colocalization colocalization 6 canx-q9wmx2_pro-1 3 Calnexin 11 unspecified role unspecified role neutral component neutral component NS5A 10 unspecified role unspecified role neutral component neutral component colocalization colocalization 6