HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Journal of virology 2009 imex curation Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation bovin-testis Bos taurus testis confocal microscopy confocal microscopy immunostaining immunostaining Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu cjones@unlnotes.unl.edu. Accepted 2015-OCT-14 AT 11:31 BST AT 11:31 BST by MGT Journal of virology 2009 imex curation The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Journal of virology 2009 imex curation Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation bovin-mdbk Bos taurus mdbk Madin-Darby bovine kidney cells confocal microscopy confocal microscopy immunostaining immunostaining Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu cjones@unlnotes.unl.edu. Accepted 2015-OCT-14 AT 11:31 BST AT 11:31 BST by MGT Journal of virology 2009 imex curation The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Journal of virology 2009 imex curation Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-p19 Mus musculus embryonic teratocarcinoma cell line, epithelial-like, induced by retinoic acid p19 mouse embryonic teratocarcinoma cellline confocal microscopy confocal microscopy immunostaining immunostaining Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu cjones@unlnotes.unl.edu. Accepted 2015-OCT-14 AT 11:31 BST AT 11:31 BST by MGT Journal of virology 2009 imex curation The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Journal of virology 2009 imex curation Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-p19 Mus musculus embryonic teratocarcinoma cell line, epithelial-like, induced by retinoic acid p19 mouse embryonic teratocarcinoma cellline anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu cjones@unlnotes.unl.edu. Accepted 2015-OCT-14 AT 11:31 BST AT 11:31 BST by MGT Journal of virology 2009 imex curation The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Journal of virology 2009 imex curation Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-p19 Mus musculus embryonic teratocarcinoma cell line, epithelial-like, induced by retinoic acid p19 mouse embryonic teratocarcinoma cellline anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu cjones@unlnotes.unl.edu. Accepted 2015-OCT-14 AT 11:31 BST AT 11:31 BST by MGT Journal of virology 2009 imex curation The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Journal of virology 2009 imex curation Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu 21-10-2015: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. confocal microscopy confocal microscopy immunostaining immunostaining Saira K., Zhou Y., Jones C. Virus - Publications including interactions involving viral proteins Based on authors email, transfected IRF7 is human in origin, and bICP0 is from strain Cooper. As there is no Cooper strain UniProt/Genbank identifier for bICP0, UniProt identifier P29128 has been used as this has 100% match with the sequence (aa 13–51) for bICP0 as given in Reference 18 in this publication -pmid:11172088. cjones@unlnotes.unl.edu cjones@unlnotes.unl.edu. Accepted 2015-OCT-14 AT 11:31 BST AT 11:31 BST by MGT Journal of virology 2009 imex curation irf7_human Interferon regulatory factor 7 IRF7 protein protein human Homo sapiens Human MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPSACTAVQEPSPGALDVTIMYKGRTVLQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKSLVLVKLEPWLCRVHLEGTQREGVSSLDSSSLSLCLSSANSLYDDIECFLMELEQPA 9863C147514652DE a8e4q6_bovin IRF7 protein protein bovin Bos taurus (Bovine) Bovine MAEAPDRGTPRVLFGDWLLGEVSSGRYEGLRWLDAARTRFRVPWKHFARKDLGEADSRIFKAWAVARGRWPLRSGGGAPPIPESALRASWKTNFRCALRSTQRFVMLEDNSGDPTDPHKVYKISSEPGCPEGLGFDQGEDEALEDAPPARGGLLGPCLASDTGESLGHRLNPEPCPPSLAGDARDLLIQALQQSCLEDHLLDLTPPEAPDAGPPPEPWQPLEAEPHMGASASACTPMAGEPPLAGPGYSQLGLQPEPSLGALDLSILYKGRTVLQEVVGRPRCVPLYGPSAVAGGAPAPQQVAFPSPAGLPDQKQLHYTEKLLQHVAPGLQLELRGPWLWARRLGKCKVYWEVGGPLGSASTSSPARLLPRDCDTPIFDFGTFFQELLEFRAQRRRGSPHYTIYLGFGQDLSVGRPKEKSLVLVKLEPWLCRAYLEAVQREGVSSLDSGSLSLCLSSSNSLYEDLEHFLEHFLMEVEQAA FE6447E451EFF3D0 icp0_bhv1j E3 ubiquitin-protein ligase ICP0 BICP0 IER 2.9/ER2.6 P135 protein RING-type E3 ubiquitin transferase ICP0 protein protein BoHV-1 Bovine herpesvirus 1.1 (strain Jura) Infectious bovine rhinotracheitis virus MAPPAAAPELGSCCICLDAITGAARALPCLHAFCLACIRRWLEGRPTCPLCKAPVQSLIHSVASDECFEEIPVGGGPGADGALEPDAAVIWGEDYDAGPIDLTAADGEASGAGGEAGAADGSEAGGGAGGAEEAGEARGAGAGRAAGAAGGRAGRGADAAQEFIDRVARGPRLPLLPNTPEHGPGAPYLRRVVEWVEGALVGSFAVTARELAAMTDYVMAMLAECGFDDDGLADAMEPLIGEDDAPAFVRSLLFVAARCVTVGPSHLIPQQSAPPGGRGVVFLDTSDSDSEGSEDDSWSESEESSSGLSTSDLTAIDDTETEPETDAEVESRRTRGASGAARARRPAERQYVSTRGRQTPAVQPAPRSLARRPCGRAAAVSAPPSSRSRGGRRDPRLPAAPRAAPAAQARACSPEPREEGRGAGLGVAAGETAGWGAGSEEGRGERRARLLGEAGPPRVQARRRRRTELDRAPTPAPAPAPAPAPISTVIDLTANAPARPADPAPAAAPGPASAGAQIGTPAAAAAVTAAAAAPSVARSSAPSPAVTAAATSTAAAISTRAPTPSPAGRAPAADPRRAGAPALAGAARAEVGRNGNPGRERRPASAMARGDLDPGPESSAQKRRRTEMEVAAWVRESLLGTPRRSSAALAPQPGGRQGPSLAGLLGRCSGGSAWRQ 11B06BA4E5C4EB71 bicp0-irf7-1 5 7 unspecified role unspecified role bait bait 9 unspecified role unspecified role prey prey n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association 2A irf7-bicp0-1 4 7 unspecified role unspecified role prey prey 9 unspecified role unspecified role bait bait n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association 2B bicp0-irf7-2 3 7 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range colocalization colocalization 3 bicp0-irf7-4 1 7 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range colocalization colocalization 3 bicp0-irf7-3 6 7 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range colocalization colocalization 3 and 4B bicp0-irf7-5 2 8 unspecified role unspecified role neutral component neutral component 9 unspecified role unspecified role neutral component neutral component n_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range colocalization colocalization 4D