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    <source releaseDate="2022-02-03">
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        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Vaccinia virus E3 protein prevents the antiviral action of ISG15.</fullName>
        </names>
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            <attribute name="publication title" nameAc="MI:1091">Vaccinia virus E3 protein prevents the antiviral action of ISG15.</attribute>
            <attribute name="journal" nameAc="MI:0885">PLoS Pathog. (1553-7366)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
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            <attribute name="rapid curation" nameAc="MI:0961"/>
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            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="remark-internal">suggested by panni</attribute>
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        <hostOrganismList>
          <hostOrganism ncbiTaxId="-3">
            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>fluorescence imaging</shortLabel>
            <fullName>fluorescence microscopy</fullName>
            <alias type="synonym" typeAc="MI:1041">fluorescence imaging</alias>
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        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
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          <attribute name="author-list" nameAc="MI:0636">Guerra S., Cáceres A., Knobeloch KP., Horak I., Esteban M.</attribute>
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          <attribute name="remark-internal">suggested by panni</attribute>
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          <fullName>Vaccinia virus E3 protein prevents the antiviral action of ISG15.</fullName>
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            <attribute name="remark-internal">suggested by panni</attribute>
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        <hostOrganismList>
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            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
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          <attribute name="author-list" nameAc="MI:0636">Guerra S., Cáceres A., Knobeloch KP., Horak I., Esteban M.</attribute>
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          <attribute name="remark-internal">suggested by panni</attribute>
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          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
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          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>e3_vaccw</shortLabel>
          <fullName>Protein E3</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">p25</alias>
          <alias type="orf name" typeAc="MI:0306">E3L</alias>
          <alias type="locus name" typeAc="MI:0305">VACWR059</alias>
        </names>
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          <secondaryRef db="mint" dbAc="MI:0471" id="P21605"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="YP_232941.1"/>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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        </interactorType>
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          <names>
            <shortLabel>vaccw</shortLabel>
            <fullName>vaccinia virus (stra</fullName>
            <alias type="synonym" typeAc="MI:1041">Vaccinia virus (strain WR)</alias>
            <alias type="synonym" typeAc="MI:1041">VACV</alias>
          </names>
        </organism>
        <sequence>MSKIYIDERSNAEIVCEAIKTIGIEGATAAQLTRQLNMEKREVNKALYDLQRSAMVYSSDDIPPRWFMTTEADKPDADAMADVIIDDVSREKSMREDHKSFDDVIPAKKIIDWKGANPVTVINEYCQITRRDWSFRIESVGPSNSPTFYACVDIDGRVFDKADGKSKRDAKNNAAKLAVDKLLGYVIIRF</sequence>
        <attributeList>
          <attribute name="crc64">C76888864BE662AC</attribute>
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      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>ub2l6_human</shortLabel>
          <fullName>Ubiquitin/ISG15-conjugating enzyme E2 L6</fullName>
          <alias type="gene name" typeAc="MI:0301">UBE2L6</alias>
          <alias type="gene name synonym" typeAc="MI:0302">UBCH8</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Ubiquitin-protein ligase L6</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Ubiquitin carrier protein L6</alias>
          <alias type="gene name synonym" typeAc="MI:0302">UbcH8</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Retinoic acid-induced gene B protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">E2 ubiquitin-conjugating enzyme L6</alias>
        </names>
        <xref>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032020" version="SP_200"/>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS</sequence>
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          <attribute name="remark-internal">DIP protein O14933 original sequence version: 136</attribute>
          <attribute name="crc64">D79768775344EFAE</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="5">
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          <shortLabel>e3-ube2l6</shortLabel>
        </names>
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        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="6">
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              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741177" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O14933"/>
            </xref>
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
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                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
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            </experimentalRoleList>
          </participant>
          <participant id="7">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741179" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P21605"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F5</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
      <interaction id="8">
        <names>
          <shortLabel>e3-ube2l6-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741183" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009859" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="9">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741186" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O14933"/>
            </xref>
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="10">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741184" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P21605"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>colocalization</shortLabel>
            <fullName>colocalization</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F5</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>