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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>MINT</shortLabel>
        <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
        <alias type="synonym" typeAc="MI:1041">MINT</alias>
      </names>
      <bibref>
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      <attributeList>
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        <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
        <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
        <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
        <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulator-associated ligand and promotes E6-associated protein-mediated ubiquitination and proteasomal degradation.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="16878151" refType="primary-reference" refTypeAc="MI:0358"/>
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            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8592592" refType="identity" refTypeAc="MI:0356"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulator-associated ligand and promotes E6-associated protein-mediated ubiquitination and proteasomal degradation.</attribute>
            <attribute name="journal" nameAc="MI:0885">Oncogene (0950-9232)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2007</attribute>
            <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
            <attribute name="rapid curation" nameAc="MI:0961"/>
            <attribute name="author-list" nameAc="MI:0636">Jeong KW., Kim HZ., Kim S., Kim YS., Choe J.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
            <attribute name="remark-internal">manually identified</attribute>
            <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628445" refType="identity" refTypeAc="MI:0356"/>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-3">
            <names>
              <shortLabel>unknown</shortLabel>
              <fullName>Unknown</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Jeong KW., Kim HZ., Kim S., Kim YS., Choe J.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
          <attribute name="remark-internal">manually identified</attribute>
          <attribute name="remark-internal">manually identified</attribute>
          <attribute name="journal" nameAc="MI:0885">Oncogene (0950-9232)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2007</attribute>
          <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
          <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>ve6_hpv18</shortLabel>
          <fullName>Protein E6</fullName>
          <alias type="gene name" typeAc="MI:0301">E6</alias>
        </names>
        <xref>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_040310.1"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006351" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030165" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030430" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039502" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039526" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039548" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0039649" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042025" version="SP_132"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" version="SP_132"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001334" version="SP_132"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR038575" version="SP_132"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2I04" version="SP_132"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2I0I" version="SP_132"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2I0L" version="SP_132"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5K4F" version="SP_132"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6SJV" version="SP_132"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZFD" version="SP_132"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZFG" version="SP_132"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P06463"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-44730N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
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          </xref>
        </interactorType>
        <organism ncbiTaxId="333761">
          <names>
            <shortLabel>hpv18</shortLabel>
            <fullName>Human papillomavirus type 18</fullName>
          </names>
        </organism>
        <sequence>MARFEDPTRRPYKLPDLCTELNTSLQDIEITCVYCKTVLELTEVFEFAFKDLFVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIRCLRCQKPLNPAEKLRHLNEKRRFHNIAGHYRGQCHSCCNRARQERLQRRRETQV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P06463 original sequence version: 80</attribute>
          <attribute name="crc64">5BCF13CF43D157FA</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>gopc_human</shortLabel>
          <fullName>Golgi-associated PDZ and coiled-coil motif-containing protein</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">CAL</alias>
          <alias type="gene name synonym" typeAc="MI:0302">FIG</alias>
          <alias type="gene name" typeAc="MI:0301">GOPC</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PDZ protein interacting specifically with TC10</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CFTR-associated ligand</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Fused in glioblastoma</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9HD26" version="SP_51" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A6NM30" version="SP_62" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q59FS4" version="SP_51" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q969U8" version="SP_51" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000357484" version="SP_183" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001017408.1"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044325" version="SP_183"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045176" version="SP_183"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000009" version="SP_183"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001478" version="SP_183"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036034" version="SP_183"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JOE" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JOF" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JOG" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JOH" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JOJ" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JOK" version="SP_183"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4K6Y" version="SP_183"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4K78" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4NMO" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4NMP" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4NMQ" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4NMR" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4NMS" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4NMT" version="SP_183"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_183"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5IC3" version="SP_183"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5K4F" version="SP_183"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XNJ" version="SP_183"/>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013406" version="SP_183"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" version="SP_183"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY</sequence>
        <attributeList>
          <attribute name="crc64">8A19DDC376DCD0F4</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4">
        <names>
          <shortLabel>e6-gopc</shortLabel>
        </names>
        <xref>
          <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628447" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8592611" refType="identity" refTypeAc="MI:0356"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628450" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9HD26"/>
            </xref>
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <xref>
              <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628448" refType="identity" refTypeAc="MI:0356"/>
              <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P06463"/>
            </xref>
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">F2</attribute>
          <attribute name="comment" nameAc="MI:0612">homomint</attribute>
          <attribute name="comment" nameAc="MI:0612">mint</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>